A5100437528- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Heat shock proteins research
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Antimicrobial Peptides and Activities
- RNA modifications and cancer
- Chemotherapy-related skin toxicity
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Medical Research and Treatments
- Neuroblastoma Research and Treatments
- Skin Protection and Aging
- Liver physiology and pathology
Southern Medical University
2022
Soochow University
2012-2021
The First People's Hospital of Changzhou
2014-2021
Chengdu University of Traditional Chinese Medicine
2020
University of Hong Kong
2015-2020
Guangdong Provincial Hospital of Traditional Chinese Medicine
2020
Army Medical University
2018
Wannan Medical College
2016
Shanxi Academy of Medical Sciences
2016
Shanxi Dayi Hospital
2016
Abstract The cancer stem cell (CSC) hypothesis suggests that a subset of cells possesses properties and is crucial in tumor initiation, metastasis, drug resistance. To determine the mechanism CSCs breast cancer, we focused on LGR5, marker adult potentially serves as functional factor CSCs. LGR5 overexpression was detected significantly associated with recurrence poor outcome. promoted mobility, formation, epithelial-mesenchymal transition by activating Wnt/β-catenin signaling. In addition,...
The protein containing the C2 domain has been well documented for its essential roles in endocytosis, cellular metabolism and cancer. Tac2-N (TC2N) is a tandem domain-containing protein, but function, including role tumorigenesis, remains unknown. Here, we first identified TC2N as novel oncogene lung was preferentially upregulated cancer tissues compared with adjacent normal tissues. High expression significantly associated poor outcome of patients. Knockdown markedly induces cell apoptosis...
BACKGROUND AND PURPOSE γ‐Secretase modulators represent a promising therapeutic approach for Alzheimer's disease (AD) because they selectively decrease amyloid β 42 (Aβ42), particularly neurotoxic Aβ species that accumulates in plaques the brains of patients with AD. In present study, we describe vitro and vivo pharmacological properties potent novel γ‐secretase modulator, 2‐(S)‐(3,5‐bis(4‐(trifluoromethyl)phenyl)phenyl)‐4‐methylpentanoic acid (JNJ‐40418677). EXPERIMENTAL APPROACH The...
The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation co-inhibitory molecules is associated with reduced antitumor immunity and cancer immune evasion. FDA approval immunotherapy antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) programmed cell death-1 (PD-1)—both ligands family—demonstrate impact these checkpoint regulators cancer. Using data from cBioPortal, we performed comprehensive molecular profiling 10...
Increasing evidence has demonstrated that the heat shock protein 70 (HSP70) gene may be closely associated with tissue fibrosis; however, association between HSP70 and liver fibrosis remains to fully elucidated. The present study hypothesized geranylgeranylacetone (GGA) exerts beneficial effects on though upregulation of expression HSP70. Liver was induced in rats using carbon tetrachloride (CCl4). were subsequently divided into three groups: Control group, CCl4 model group + GGA group....
Despite the large-scale clinical application of programmed death-ligand 1 (PD-L1) monoclonal antibody, reduction in its response rate has become a gradual problem. As such, use PD-L1 antibody combination with other anticarcinoma drugs been main strategy improving efficacy. Interleukin 10 (IL10) is recognized inflammatory and immunosuppressive factor. Previous studies have suggested that there link between IL10.This study was aimed at clarifying relationship IL10 liver hepatocellular...
Background: Programmed death-ligand 1 (PD-L1) plays a critical role in host immunity the setting of cancer progression. Interleukin 10 (IL-10) is multi-cellular, multi-functional cytokine that regulates cell growth and differentiation participates inflammatory immune responses. The purpose this study was to clarify relationship between PD-L1 IL-10 their clinical importance esophageal carcinoma (ESCA). Methods: ESCA patients (n=100) who underwent surgery with preoperative therapy were...
The incidence of cancer has been staying at a high level worldwide in recent years. With advances diagnosis and therapy strategy, the survival rate patients with increasing, but side effects these treatments, especially chemotherapy, are obvious even when chemotherapy ceases. YH0618, prescription, showed efficacy reducing chemotherapy-induced toxicity through long clinical practice. However, there is no scientific research exploring YH0618 cancer. Therefore, using randomized controlled...
Abstract Background NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of type I IFN response and immune escape melanoma is still unknown. Methods The CRISPR/Cas9 system was used to generate NOS1-knockout cells biological characteristics were evaluated by MTT assay, clonogenic EdU flow cytometric assay. effect on tumor growth tested BALB/c-nu C57BL/6 mouse models. gene profiles detected Affymetrix microarray RNA-seq KEGG (Kyoto Encyclopedia...
Benign esophageal strictures (BESs) frequently results from fibrosis. The transformation of fibroblasts into fibrocyte is an important cause treatment fibrosis challenging. Some previous studies have indicated the antifibrotic effect mitomycin C (MMC). However, mechanism action MMC and its optimal dose for remains unclear. In present study, role in fighting was investigated. Human fibroblast cells (HEFs)were treated without or with MMC, at 2, 5, 10 μg/ml, combining mimic lncRNA-ATB, miR-200b...
Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T>C, rs10932029 CD28 rs3116496 T>C and CD80 rs7628626 C>A SNPs assessed potential relationship these with hepatocellular carcinoma (HCC) risk. A total 584 HCC cases 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain genotypes ICOS, polymorphisms. found that ICOS polymorphism significantly...
The prognosis of postoperatively recurred malignant schwannoma is poor and there no effective treatment. We had a patient who was found to have large intrathoracic tumor 1 year after surgery could not tolerate an operation for the second time. then decided evaluate synergistic effect recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy patient. rAd-p53 injected intratumorally twice week before radiotherapy, total 10 times, over course Radiotherapy followed gene therapy at five...
Cell-surface carbohydrate chains are known to contribute cell migration, interaction, and proliferation. β-1,4-galactosyltransferase-I (β-1,4-GalT-I), which is one of the best-studied glycosyltransferases, plays a key role in synthesis type 2 N-glycans core branch O-glycans. Recently, it has been reported that skin wound healing significantly delayed β-1,4-GalT-I−/− mice. However, expression β-1,4-GalT-I its biological function wound-healing process remain be elucidated. We used real-time...
Abstract Background Programmed death-ligand1 (PD-L1) plays a critical role in host immunity the setting of cancer progression. Interleukin 10 (IL-10) is multi-cellular, multi-functional cytokine that regulates cell growth and differentiation participates inflammatory immune responses. The purpose this study was to clarify relationship between PD-L1 IL-10 their clinical importance liver hepatocellular carcinoma(LIHC).Methods LIHC patients (n=100) who underwent surgery with preoperative...
Objective To analysis the clinical effects and introduce organization of standardized diagnosis treatment system in adult outpatients with cancer pain. Methods Under cooperation many departments including outpatient office, pharmacy, oncology pain medicine, NCCN Oncology-Adult Cancer Pain Guideline was applied to patients, degree adverse reactions 72 patients were summarized after treatment. Results The number cases moderate severe reduced from 67 (93.1%) 34 (47.2%)...
Objective To identify the differentially expressed circular RNA (circRNA) in gastric cancer and explore biological function of hsa_circ_0005692. Methods Eight cases their adjacent tissues were selected to detect circRNA by microarray analysis. The changes 10 circRNAs confirmed reverse transcriptase-polymerase chain reaction (RT-PCR). migration ability was analyzed wound healing assay. invasive Transwell proliferation cells measured cell counting kit-8 (CCK-8). Results A total...