A5025234353- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Effects and risks of endocrine disrupting chemicals
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Cytokine Signaling Pathways and Interactions
- Research in Cotton Cultivation
- Microplastics and Plastic Pollution
- Hippo pathway signaling and YAP/TAZ
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- High Altitude and Hypoxia
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Birth, Development, and Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Army Medical University
2014-2023
Zhejiang University
2023
Ministry of Agriculture and Rural Affairs
2023
Qingdao Binhai University
2023
Ocean University of China
2022
Kunming Medical University
2022
University of Manchester
2021
State Council of the People's Republic of China
2020
Lanzhou University Second Hospital
2019
State Key Laboratory of Cotton Biology
2019
Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Alveolar epithelial cells play crucial role in via epithelial-mesenchymal transition (EMT). Exosomes derived from mesenchymal stem own the beneficial properties to repair and regeneration damaged tissues, however underlying mechanisms remain poorly understood.Mouse cells-derived exosomes (mMSCs-Exo) were isolated by differential centrifugation, their protective effects assessed vivo vitro, respectively....
Verticillium wilt (VW), also known as "cotton cancer," is one of the most destructive diseases in global cotton production that seriously impacts fiber yield and quality. Despite numerous attempts, little significant progress has been made improving VW resistance upland cotton. The development chromosome segment substitution lines (CSSLs) from Gossypium hirsutum × G. barbadense emerged a means simultaneously developing new varieties with high-yield, superior fiber, to VW. In this study,...
Abiotic stresses such as salinity and low temperature have serious impact on peanut growth yield. The present work investigated the function of a MYB-related transcription factor gene AhMYB30 obtained from under salt by transgenic methods. results indicated that overexpression in Arabidopsis could enhance resistance plants to freezing stresses. expression stress-response genes RD29A (Response-to-Dehydration 29A), COR15A (Cold-Regulated 15A), KIN1 (Kinesin 1) ABI2 (Abscisic acid Insensitive...
Although members of SOX family have been well documented for their essential roles in embryonic development, cell proliferation and disease, the functional role molecular mechanism SOX30 cancer are largely unexplored. Here, we first identified SRY-box containing gene 30 (SOX30) as a novel preferentially methylated using genome-wide methylation screening. hypermethylation was detected 100% lung lines (9/9) 70.83% (85/120) primary tumor tissues compared with none (0/20) normal 8.0% (2/25)...
LIM homeobox domain 6 (LHX6) is a putative transcriptional regulator that controls the differentiation and development of neural lymphoid cells. However, function LHX6 in cancer remains largely unclear. Recently, we found hypermethylated lung cancer. In this study, analysed its epigenetic regulation, biological functions, related molecular mechanisms Methylation status was evaluated by methylation-specific PCR bisulfite genomic sequencing. mRNA levels were measured relation to methylation...
The protein containing the C2 domain has been well documented for its essential roles in endocytosis, cellular metabolism and cancer. Tac2-N (TC2N) is a tandem domain-containing protein, but function, including role tumorigenesis, remains unknown. Here, we first identified TC2N as novel oncogene lung was preferentially upregulated cancer tissues compared with adjacent normal tissues. High expression significantly associated poor outcome of patients. Knockdown markedly induces cell apoptosis...
Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism this metastasis remains unclear. Here, we investigate in that SOX30 sharply under-expressed metastatic tumors compared with non-metastatic tumors, and suppresses plenty related processes or pathways. strongly inhibits tumor cell vitro vivo. Sox30 deficiency promotes Sox30−/− mice uncontrollable lung-metastasis re-inhibited upon re-expression. Mechanistically, diminishes Wnt-signaling via directly...
ALX4 is a paired-like homedomain transcription factor mainly expressed in the mesenchymal compartment of variety developing tissues, but its functions, regulation mechanisms and clinical values breast cancer remains unclear.The expression cell lines patients' tissues were detected by RT-PCR, qPCR western blot. Furthermore TCGA database was applied to confirm these results. MSP BSP methods used assess methylation promoter region. In vitro proliferation, metastasis vivo nude mice model...
Non-obstructive azoospermia (NOA) is the most severe form of male infertility. However, etiology NOA largely unknown, resulting in a lack clinical treatments. Here, we performed comparative genome-wide profiling DNA methylation and identified SOX30 as notably hyper-methylated gene at promoter testicular tissues from patients. This hyper-methylation directly causes its silencing expression NOA. The reduced levels are correlated with severity disease. Deletion Sox30 mice uniquely impairs...
XAF1 (XIAP-associated factor 1) is a novel XIAP binding protein that can antagonize and sensitize cells to other cell death triggers. Our previous results have shown aberrant hypermethylation of the CpG sites in promoter strongly associated with lower expression gastric cancers. In our study, we investigated effect restoration on growth We found suppressed anchorage-dependent -independent increased sensitivity TRAIL drug-induced apoptosis. Stable clones expressing exhibited delayed tumor...
Abstract In our previous study, we had identified SOX30 as a novel tumor suppressor that acts through direct regulation of p53 transcription in human lung cancer. Here, sought to determine the clinical relevance expression series surgically-resected non-small cell cancer (NSCLC) patients. Analysis and clinico-pathologic features reveal significant correlation with histological type (n = 220, P 0.008) stage 0.024). Kaplan-Meier analysis indicates an association high better prognosis NSCLC...
Using genome-wide methylation screening, we found Aristaless-like homeobox-4 (ALX4) preferentially methylated in lung cancer. ALX4 is a putative transcription factor that belongs to the family of paired-class homeoproteins involved epithelial development. However, role tumorigenesis remains largely unclear. Here, analyzed its epigenetic regulation, biological functions and related molecular mechanisms CpG island expression were evaluated by methylation-specific polymerase chain reaction...
Different histological subtypes of non-small cell lung cancer (NSCLC) show different molecular characteristics and responses to therapeutic strategy. Identification specific gene, clarification its special roles mechanisms are crucial for developing new approach particular subtype patients. Surgical specimens 540 NSCLC patients were recruited. Immunohistochemistry was used detect SOX30 expression, correlations with clinical parameters analyzed. Functional experiments gene ontology analysis...
The expression of desmosomal genes in lung adenocarcinoma and squamous carcinoma is different. However, the regulatory mechanism gene remains unknown.The correlation between SOX30 were analyzed by bioinformatics. SOX30, DSP, JUP DSC3 detected cancer cell lines, tissues mice patients' qPCR, WB, Immunofluorescence Immunohistochemistry. A chromatin Immunoprecipitation assay was used to investigate mechanisms regulation on expression. In vitro proliferation, migration invasion assays, an vivo...