A5101551335- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Musculoskeletal pain and rehabilitation
- Animal Disease Management and Epidemiology
- CRISPR and Genetic Engineering
- Viral Infections and Immunology Research
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Musculoskeletal Disorders and Rehabilitation
- Trace Elements in Health
- Diabetic Foot Ulcer Assessment and Management
- Circular RNAs in diseases
- Statistical Methods and Inference
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Traumatic Brain Injury and Neurovascular Disturbances
- Shoulder Injury and Treatment
- Statistical Methods and Bayesian Inference
- Glycosylation and Glycoproteins Research
Affiliated Hospital of Youjiang Medical University for Nationalities
2024-2025
Northwest A&F University
2011-2025
Soochow University
2017-2025
First Affiliated Hospital of Zhengzhou University
2024
Southern University of Science and Technology
2021-2024
Huazhong University of Science and Technology
2024
Nanjing Maternity and Child Health Care Hospital
2008-2023
Nanjing Medical University
2008-2023
First Affiliated Hospital of GuangXi Medical University
2022
Guangxi Medical University
2022
M2-polarized tumor-associated macrophages (TAMs) are key regulators of the link between inflammation and cancer. A negative correlation infiltration intensity TAMs prognosis pancreatic cancer has been reported. Epithelial-mesenchymal transition (EMT) is an important biological process in progression primary tumors toward metastasis. Inflammation-induced EMT previously shown, therefore, we hypothesized could induce Toll-like receptor 4 (TLR4) signaling active role tumor during chronic...
ABSTRACT The Period 2 ( Per2 ) gene is a key molecular component in controlling mammalian circadian rhythms at the levels of expression, physiology, and pathogenesis. Although many immune parameters, such as number different subtypes circulating cells level cytokine production response to infection with bacteria viruses, have been well documented display pattern mammals, basic features clock components system role genes regulating host defenses remain uncharacterized. Previously, we reported...
Knee and hip osteoarthritis (OA) are known risk factors for falls, but whether they together additionally contribute to falls is unknown. This study utilizes a biracial cohort of men women examine the influence lower-extremity OA burden on future falls.
(−)-Epigallocatechin gallate (EGCG) and curcumin are two naturally derived agents that have been widely investigated worldwide. They exhibit their anti-tumor effects in many types of cancers. In the current study, effect combination on non-small cell lung cancer (NSCLC) cells was investigated. The results revealed at low concentrations, EGCG strongly enhanced cycle arrest. Flow cytometry analysis showed were arrested G1 S/G2 phases. Two main related proteins cyclin D1 B1 significantly...
Antibody-drug conjugates (ADC), potent cytotoxic drugs linked to antibodies via chemical linkers, allow specific targeting of neoplastic cells. We have used this technology develop the ADC DCDT2980S that targets CD22, an antigen with expression limited B cells and vast majority non-Hodgkin lymphomas (NHL). consists a humanized anti-CD22 monoclonal IgG1 antibody microtubule-disrupting agent, monomethyl auristatin E (MMAE), reduced cysteines protease cleavable linker,...
Endometriosis is a common gynecological disease, yet its pathogenesis remains poorly understood. Recent studies have demonstrated that the aberrant expression of certain microRNAs (miRNAs) may correlate with development and progression endometriosis. In this study, we profiled several differentially expressed miRNAs in normal, eutopic ectopic endometrium by miRNA microarray screening analysis, among which, miR-183 was found to be downregulated tissues, result further confirmed real-time PCR...
This study aimed to explore the association between dietary fiber intake and hypertension risk using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Data from National Health Nutrition Examination Survey 2007–2014 were used in this study. Dietary data obtained through two 24-h recall interviews. Hypertension was defined as systolic blood pressure (SBP) ≥ 130 mmHg or diastolic (DBP) 80 treatment with hypertensive medications. Logistic regression...
Abstract Purpose: Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates carcinogenesis of human papillomavirus–related cervical cancer. We hypothesized potentially functional polymorphisms IL12A IL12B may individually jointly contribute to cancer risk. Experimental Design: genotyped rs568408 [3′ untranslated region (UTR) G>A] rs2243115 (5′UTR T>G) rs3212227 (3′UTR A>C) hospital-based study 404 cases...
Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism this metastasis remains unclear. Here, we investigate in that SOX30 sharply under-expressed metastatic tumors compared with non-metastatic tumors, and suppresses plenty related processes or pathways. strongly inhibits tumor cell vitro vivo. Sox30 deficiency promotes Sox30−/− mice uncontrollable lung-metastasis re-inhibited upon re-expression. Mechanistically, diminishes Wnt-signaling via directly...
Abstract Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing unique model for exploring gene expression. The biosynthesis, distribution, and function mRNA N1-methyladenosine (m 1 A) remain controversial due to its limited presence in typical mRNA. This study provides comprehensive map m A dinoflagellate shows that A, rather than N6-methyladenosine 6 A), is the most prevalent internal modification various species, with an...
To investigate the clinical characteristics and prognosis of infants young children with basal ganglia infarction after minor head trauma (BGIMHT). A retrospective analysis was conducted on data follow-up results aged 28 days to 3 years BGIMHT who were hospitalized at Children's Hospital Soochow University from January 2011 2022. total 45 cases included, most common symptom being limb movement disorders (96%, 43/45), followed by facioplegia (56%, 25/45). Cerebral imaging showed that 72%...
Abstract The pivotal role of ethylene (ETH) in fruit ripening has been extensively studied; however, the function brassinosteroids (BRs) regulating remains poorly understood. Specifically, mechanism by which BRs interact with ETH to affect kiwifruit (Actinidia deliciosa) is unclear. Our research showed that two genes encoding transcription factors, AdNAC3 and AdMYB19, softening gene AdEXP3 (encoding a cell wall expansion protein, expansin 3) were upregulated downregulated BRs. Furthermore,...
Abstract Krüppel-like transcription factor (KLF)13, previously shown to regulate RANTES expression in vitro, is a member of the Krüppel- like family factors that controls many growth and developmental processes. To ascertain function KLF13 vivo, Klf13-deficient mice were generated by gene targeting. As expected, activated T lymphocytes from Klf13−/− show decreased expression. However, these also exhibit enlarged thymi spleens. TUNEL, as well spontaneous activation-induced death assays,...
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and essential for maintaining the pluripotency self-renewal of ES cells. SUMOylation has been proved to regulate several cell markers' function, such as Oct4 Sox2. strictly regulated by Oct4/Sox2 heterodimer. However, direct effects on expression remain unclear. In this study, we reported that repressed expression. Depletion Sumo1 or its conjugating enzyme Ubc9 increased Nanog, while high reduced Interestingly, found Sox2...
MicroRNAs (miRNAs), a group of noncoding RNAs, function as post-transcriptional gene regulators and control the establishment, self-renewal differentiation stem cells. Vitamin C has been recognized reprogramming enhancer because its ability to induce blastocyst-like state in embryonic cells (ESCs). However, knowledge on regulation miRNAs by vitamin ESCs is limited. In this study, we found that induced miRNA expression, particularly ESC-specific miRNAs. Moreover, maintained expression...
// Di Lu 1 , Junxiong Wang Xiaoyan Shi 2 Bing Yue and Jianyu Hao Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, 100020, China Pathology, Friendship 100050, Correspondence to: Hao, email: haojianyu@medmail.com.cn Keywords: AHNAK2, pancreatic ductal adenocarcinoma, overall survival, prognostic factor, nomogram Received: October 09, 2016     Accepted: February 21, 2017     Published: March 07, 2017 ABSTRACT...
Genetic dissection of lupus pathogenesis in the NZM2410 strain has recently revealed that Sle1 is a potent locus triggers formation IgG anti-histone/DNA antibodies, when expressed on B6 background as congenic interval. B6.lpr mice, contrast, exhibit distinctly different cellular and serological phenotypes. Both strains, however, do not usually pathogenic autoantibodies, or succumb to nephritis. In this study, we show epistatic interaction (in particular, Sle1/Sle1) with FASlpr leads massive...
Stochastic noise, susceptibility artifacts, magnetic field and radiofrequency inhomogeneities, other noise components in resonance images (MRIs) can introduce serious bias into any measurements made with those images. We formally three regression models including a Rician model two associated normal to characterize stochastic various imaging modalities, diffusion-weighted (DWI) functional MRI (fMRI). Estimation algorithms are introduced maximize the likelihood function of models. also...
Increasing evidence shows that GSDME is involved in tumor chemotherapy. Lobaplatin an important chemotherapy drug for the treatment of cervical cancer. However, exact mechanism lobaplatin cancer remains unclear. In this study, whether a new has been explored. Cell pyroptosis was measured by Counting Kit-8 and flow cytometry analyses. Western blot analysis used to check proteins expression. The cell viability significantly decreased treatment. Compared with control group, percentage (PI...