A5040012538- Reproductive System and Pregnancy
- interferon and immune responses
- Endometriosis Research and Treatment
- Animal Genetics and Reproduction
- Tuberculosis Research and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Mycobacterium research and diagnosis
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Nuclear Structure and Function
- Antimicrobial Peptides and Activities
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Trace Elements in Health
- CRISPR and Genetic Engineering
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA regulation and disease
- Reproductive Biology and Fertility
Women's Hospital, School of Medicine, Zhejiang University
2023-2024
Northwest A&F University
2013-2020
Ministry of Agriculture, Livestock, and Food Supply
2018
Aberrant epigenetic reprogramming often results in developmental defects somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason for this remains elusive. Here, we provide evidence that two H3K9 demethylase genes, lysine-specific 4D (KDM4D) 4E (KDM4E), are related to active H3K9me3/2 demethylation vitro fertilized (IVF)...
During embryo implantation, blastocyst interacts with the receptivity endometrium and endometrial epithelium secretes nurturing fluid to support embryonic development. Interferon-λ (IFN-λ) is a novel, non-redundant regulator that participates in fetal-maternal interaction; however, precise molecular mechanism underlying its impact on uterine remains elusive. Here, microarray profiling revealed 149 specific miRNAs were differentially expressed human cells following IFN-λ treatment. In...
In murine macrophages infected with Mycobacterium tuberculosis (Mtb), the level of phosphorylated STAT1 (P-STAT1), which drives expression many pro-apoptosis genes, increases quickly but then declines over a period hours. By contrast, infection induces continued increase in unphosphorylated that persists for several days. Here, we found correlated intracellular bacterial burden during later stages infection. To investigate significance high STAT1, increased its concentration exogenously, and...
Abstract Human tuberculosis (TB), caused by Mycobacterium ( Mtb ), remains a leading global health problem, causing 1.3 million deaths each year. The nuclear body protein, Sp110, has been linked to TB resistance and previous work showed that it enhances macrophage apoptosis upon infection. Here, we report on the role of Sp110 in transcriptional regulation responses through integrated transcriptome mechanistic studies. Transcriptome analysis revealed regulates genes involved immune responses,...
The mouse intracellular pathogen resistance 1 (Ipr1) gene plays important roles in mediating host immunity and previous work showed that it enhances macrophage apoptosis upon mycobacterium infection. However, to date, little is known about the regulation pattern of Ipr1 action. Recent studies have investigated protein-coding genes microRNAs regulated by macrophages, but structure functional motif protein yet be explored. In this study, we analyzed domains protein. resulting data reveal forms...
Tuberculosis remains a leading health problem worldwide and still accounts for about 1.3 million deaths annually. Expression of the mouse Sp110 nuclear body protein (Sp110) upregulates apoptotic pathway, which plays an essential role in enhancing host immunity to Mycobacterium tuberculosis (Mtb). However, mechanism this upregulation is unclear. Here, we have identified 253 proteins macrophages that interact with Sp110, 251 were previously uncharacterized. The results showed interacts heat...
In brief IFN-λs participate in the fetal–maternal immune interaction, involving regulation, uterine receptivity, cell migration and adhesion, endometrium apoptosis. Our study helps to elucidate underlying causes of deficiency spontaneous pregnancy loss women. Abstract Immunotherapy has been commonly used prevent recurrent women with inadequate uterus receptivity or immunological imbalance. Many regulators are now identified as having crucial roles at embryo–maternal interface. However,...
In recent years, transgenic technology has been widely applied in many fields. There is concern about the safety of genetically modified (GM) products with increased prevalence GM products. order to prevent mastitis dairy cows, our group produced cattle expressing human beta-defensin-3 (HBD3) their mammary glands, which confers resistance bacteria that cause mastitis. The milk derived from these thus contained HBD3. objective present study was analyze nutritional composition HBD3 and conduct...
Abstract Problem Interferon‐λ (IFN‐λ) is a novel non‐redundant regulator that participates in the fetal–maternal immune interaction, including regulation, uterine receptivity, cell migration and adhesion, endometrium apoptosis. However, exact transcriptional foundation for endometrial signaling of IFN‐λ not completely understood, studies regarding to implantation failure vivo are limited. Method study The gene expression profile human Ishikawa line treated with or IFN‐α (100 ng/mL) 6 h was...
Intracellular pathogen resistance 1 (Ipr1) has been found to be a mediator integrate cyclic GMP-AMP synthase (cGAS)-interferon regulatory factor 3 (IRF3), activated by intracellular pathogens, with the p53 pathway. Previous studies have shown process of Ipr1 induction various immune reactions, including bacterial and viral infections. The present study demonstrated that is regulated cGAS-IRF3 pathway during pathogenic infection. IRF3 was regulate expression directly binding...