Abstract Simple and inexpensive polyhalides (CCl 4 C 2 Cl 6 ) have been found to be effective versatile oxidants in removing electrons from Breslow intermediates under N‐heterocyclic carbene (NHC) catalysis. This oxidative reaction involves multiple single‐electron‐transfer (SET) processes several radical intermediates. The α, β, γ‐carbon atoms of aldehydes enals could readily functionalized. Given the low cost broad applicability reactions, this study is expected greatly enhance feasibility...

The aim of this study was to isolate human mesenchymal stem cells (MSCs) from the gingiva (GMSCs) and confirm their multiple differentiation potentials, including odontogenic lineage. GMSCs, periodontal ligament (PDLSCs) dermal (DSCs) cultures were analyzed for cell shape, cycle, colony-forming unit-fibroblast (CFU-F) markers. Cells then induced osteogenic adipogenic markers (alkaline phosphatase (ALP) activity, mineralization nodule formation Runx2, ALP, osteocalcin (OCN) collagen I...

Diabetics have an increased prevalence of periodontitis, and diabetes is one the causative factors severe periodontitis. Apoptosis thought to be involved in this pathogenic relationship. The aim study was investigate apoptosis human periodontal ligament (PDL) fibroblasts induced by advanced glycation end products (AGEs) their receptor (RAGE). We examined roles apoptosis, AGEs, RAGE during periodontitis mellitus using cultured PDL that were treated AGE-modified bovine serum albumin (AGE-BSA),...

A catalyst- and metal-free electrochemical hydrodehalogenation of aryl halides is disclosed. Our reaction by a flexible protocol operated in an undivided cell equipped with inexpensive graphite rod anode cathode. Trialkylamines nBu3 N/Et3 N behave as effective reductants hydrogen atom donors for this reductive reaction. Various heteroaryl bromides worked effectively. The typically less reactive chlorides fluorides can also be smoothly converted. utility our method demonstrated detoxification...

Aims/Background Lobar pneumonia is an acute inflammation with increasing incidence globally. Delayed treatment can lead to severe complications, posing life-threatening risks. Thus, it crucial determine effective methods improve the prognosis of children lobar pneumonia. Therefore, this study aimed assess clinical efficacy pidotimod-assisted erythromycin in treating over 3 years old. Methods This included 108 admitted Huoqiu First People's Hospital, China, between March 2021 and 2024....

Zishen Yuzhen Pill (ZYP) is a Chinese herbal product developed by Shenzhen TCM Hospital, which have been frequently used to treat osteoporosis (OP). This study aimed determine the major chemical components of ZYP and its prototype compounds metabolites in rat biological samples, as well explore potential effect ZYP-containing serum MC3T3-E1 cells. UPLC-Q/TOF-MS was identify components. Then, orally administered rat, samples plasma, urine, feces, bile, tissue were collected metabolites. The...

Objective: The aim of this in vitro study was to use high-resolution micro-computed tomography (micro-CT) and scanning electron microscopy (SEM) compare the efficacy four irrigation techniques [needle, ultrasonic, EndoActivator, photon-induced photoacoustic streaming (PIPS)] removing calcium hydroxide (Ca[OH]2) from root canal isthmus maxillary premolars. Methods: Twenty-four first premolars were selected based on presence regions micro-CT scans. Root canals instrumented with an F2 file...

In this study, a novel three-dimensional (3D) heterogeneous/bilayered scaffold was constructed to repair large defects in rabbit joints. The includes two distinct but integrated layers corresponding the cartilage and bone components. upper layer consists of gelatin, chondroitin sulphate sodium hyaluronate (GCH), lower gelatin ceramic bovine (GCBB). form 3D bilayered (GCH–GCBB), which mimics natural osteochondral matrix for use as tissue engineering. purpose study evaluate efficacy scaffold,...

Enriched environment (EE) has been proven to be an effective intervention strategy which can improve neurofunctional recovery following cerebral ischemia/reperfusion (I/R) injury. However, it still needs further investigation for the underlying mechanisms. Recently, shown that ferroptosis played essential role in pathophysiological development of ischemic stroke (IS). This study is aimed at investigating whether EE plays a neuroprotective by attenuating after I/R We used middle artery...

Abstract Simple and inexpensive polyhalides (CCl 4 C 2 Cl 6 ) have been found to be effective versatile oxidants in removing electrons from Breslow intermediates under N‐heterocyclic carbene (NHC) catalysis. This oxidative reaction involves multiple single‐electron‐transfer (SET) processes several radical intermediates. The α, β, γ‐carbon atoms of aldehydes enals could readily functionalized. Given the low cost broad applicability reactions, this study is expected greatly enhance feasibility...

To compare the mid-long-term clinical and radiological outcomes between a combination of cortico-cancellous iliac bone graft with vascularized greater trochanter flap (Group A) isolate B) in treatment Osteonecrosis Femoral Head (ONFH).

Existing knowledge of the role epigenetic modifiers in pancreas development has exponentially increased. However, function TET dioxygenases pancreatic endocrine specification remains obscure. We set out to tackle this issue using a human embryonic stem cell (hESC) differentiation system, which TET1/TET2/TET3 triple knockout cells display severe defects β-cell specification. The integrative whole-genome analysis identifies unique cell-type-specific hypermethylated regions (hyper-DMRs)...

OBJECTIVES: Butorphanol tartrate is a synthetic opioid partial agonist analgesic.Butorphanol targets the heart, mainly via κ-opioid receptor (κ-OR) activation.The purpose of this study was to determine effect and mechanism underlying butorphanol postconditioning (B-Post) on myocardial ischaemia reperfusion injury in rats. METHODS:Seventy-five male Sprague-Dawley rats were randomly divided into five groups 15 each: Group sham; I/R (ischaemia/reperfusion); B (butorphanol postconditioning); B/N...

Abstract Background Osteonecrosis of the femoral head (ONFH) is a disabling disease, which often involves young patients. Recently, various hip-preserving surgeries were recommended to delay total hip arthroplasty (THA). Questions/purposes This study aimed compare clinical outcomes and survival rate in long-term follow-up between core decompression combined with non-vascularized autologous fibular graft (group A) an allogeneic B) for treatment ONFH. Patients methods We retrospectively...

ABSTRACT Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis and Tannerella forsythia are oral pathogens associated with periodontitis. The association between these three bacteria periodontal disease has been reported in populations of many countries. However, corresponding data Chinese still lacking. aim this study was to detect subgingival plaque collected from 468 subjects chronic periodontitis a group adults by using PCR method determine the degree target status based on...

Background: The pain caused by orthodontic treatment has been considered as tough problems in practice. There is substantial literature on which exactly effected learning and memory; tooth movement affected the emotional status showed positive outcomes. Danggui-Shaoyao-San (DSS) a Traditional Chinese Medicine prescription that used for analgesic effect via inhibiting activations of neuron glia. We raised hypothesis DSS could restore impaired abilities spatial memory regulating or glia...