A5101705865- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Thyroid and Parathyroid Surgery
- Sleep and related disorders
- Tuberculosis Research and Epidemiology
- Sleep and Work-Related Fatigue
- Autophagy in Disease and Therapy
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Ideological and Political Education
- CAR-T cell therapy research
- Hereditary Neurological Disorders
- Nerve injury and regeneration
- Hearing, Cochlea, Tinnitus, Genetics
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
Hubei University of Medicine
2012-2025
Taihe Hospital
2020-2025
Union Hospital
2024
Chinese PLA General Hospital
2017-2024
Huazhong University of Science and Technology
2020-2024
Union Hospital
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shaanxi University of Chinese Medicine
2023-2024
Affiliated Hospital of Qingdao University
2023
Parkinson's disease is a neurodegenerative disorder, and ferroptosis plays significant role in the pathological mechanism underlying disease. Rapamycin, an autophagy inducer, has been shown to have neuroprotective effects However, link between rapamycin not entirely clear. In this study, was administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model 1-methyl-4-phenylpyridinium-induced PC12 cell model. The results showed that improved behavioral symptoms of mice, reduced...
Resting-state EEG microstates are thought to reflect brief activations of several interacting components resting-state brain networks. Surprisingly, we still know little about the role these in migraine. In present study, attempted address this issue by examining patients with migraine without aura (MwoA) during interictal period and comparing them those a group healthy controls (HC).Resting-state was recorded 61 MwoA (50 females) 66 HC females). Microstate parameters were compared between...
Propofol is a commonly used general anesthetic for the induction and maintenance of anesthesia critical care sedation in children, which may add risk to poor neurodevelopmental outcome. We aimed evaluate effect propofol toward primary hippocampal neurons vitro possibly neuroprotective dexmedetomidine pretreatment, as well underlying mechanism.Primary were cultured 8 days pretreated with or without phosphorylation inhibitors prior exposure. Cell viability was measured using cell counting...
Abstract Ischemic stroke is a common disease with high morbidity and mortality. Remote ischemic preconditioning (RIPC) can stimulate endogenous protection mechanisms by inducing tolerance to reduce subsequent damage caused severe or fatal ischemia non-ischemic organs. This study was designed assess the therapeutic properties of RIPC in elucidate their underlying mechanisms. Neurobehavioral function evaluated modified neurological severity score (mNSS) test gait analysis. PET/CT used detect...
Abstract Aims We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) TLR4/Myd88 signaling pathway. Methods C57 mice were randomly divided into blank, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced artemisinin‐treated groups. Clinical symptoms, number dopaminergic (DAergic) neurons in substantia nigra, microglial activation compared among three Subsequently, BV‐2 pathway component expression MPP + ‐treated,...
Purpose: The relationship between idiopathic sleep-related phenotypes (SRPs) and sudden sensorineural hearing loss (ISSNHL) remains unclear. This study was designed to investigate the link SRPs ISSNHL from a genetic perspective through Mendelian randomization (MR) analysis. Methods: trials were downloaded Finngen database. UK Biobank FinnGen inverse variance weighted (IVW) method utilized, followed by confirming robustness reliability using MR Egger, median, simple mode, mode. heterogeneity...
In this study, a novel three-dimensional (3D) heterogeneous/bilayered scaffold was constructed to repair large defects in rabbit joints. The includes two distinct but integrated layers corresponding the cartilage and bone components. upper layer consists of gelatin, chondroitin sulphate sodium hyaluronate (GCH), lower gelatin ceramic bovine (GCBB). form 3D bilayered (GCH–GCBB), which mimics natural osteochondral matrix for use as tissue engineering. purpose study evaluate efficacy scaffold,...
Arrhythmias are the common complications following cardiac surgery and contribute to hemodynamic instability, cognitive impairment, thromboembolic events, congestive heart failure. Prevention of atrial fibrillation reduces morbidity among many available preventive approaches dexmedetomidine shows positive effects on cardiovascular stability. Even though studies indicated beneficial dexmedetomidine, power analysis conclusion these is rather weak due relatively smaller number patients in...
Hypoxic preconditioning (HPC) is neuroprotective against ischaemic brain injury; however, the roles of potential anti‑apoptotic signals in this process have not been assessed. To elucidate molecular mechanisms involved HPC‑induced neuroprotection, effects HPC on cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element‑binding protein (CREB) signalling pathway and apoptosis Sprague‑Dawley pups (postnatal day 7) treated with propofol were investigated. Western blot...
Abstract Vagal nerve stimulation (VNS) provides a novel therapeutic strategy for injured hearts by activating cholinergic anti-inflammatory pathways. However, little information is available on the metabolic pattern and arteriogenesis of VSMCs after MI. VNS has been shown to stimulate expression CPT1α, CPT1β, Glut1, Glut4 SDF-1α in coronary VSMCs, decreasing number CD68-positive macrophages while increasing CD206-positive infarcted hearts, leading decrease TNF-α IL-1β accompanied reduced...
Objective: Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning (HPC) was previously demonstrated to provide neuroprotection and brain recovery from either acute or chronic neurodegeneration in several cellular animal models. Therefore, the present study designed investigate protective effects of hypoxic on apoptosis caused by neonatal rats. Methods: Propofol (100 mg/kg) given 7-day-old (P7) Sprague Dawley pups. Before injection,...
Nerve tissue engineering is an important strategy for the treatment of brain injuries. Mesenchymal stem cell (MSC) transplantation has been proven to be able promote repair and functional recovery damage, poly (lactic-co-glycolic acid) (PLGA) also found have capability bearing cells. In present study, observe ability PLGA scaffold in supporting adherent growth MSCs neurons vivo vitro assess effects on proliferation neural differentiation MSCs, this study undertakes following steps. First,...
Propofol induces short- and long-term neurotoxicity. Our previous study showed that dexmedetomidine (Dex) can attenuate the propofol-induced acute neurotoxicity in rodents by enhancing PI3K/Akt signaling. However, whether treatment of young rats with Dex could protect them from induced propofol is unclear.Seven-day-old male Sprague Dawley were randomized injected intraperitoneally saline (100 μL, NS), mg/kg), (75 μg/kg), mg/kg) plus (25, 50 or 75 10% dimethyl sulfoxide (DMSO, 100 μL) TDZD-8...
We previously observed that amphiregulin (Areg), a ligand of epithelial growth factor receptor (EGFR), was highly expressed in lipopolysaccharide (LPS)-induced acute lung injury (ALI) tissues mainly by the classically activated (M1) alveolar macrophages (AMs). Areg also plays protective role LPS-induced and cells (AECs). However, whether is co-expressed with tumor necrosis (TNF)-α ALI tissues, can directly inhibit TNF-α-induced AEC remains unclear. first detected kinetic expressions TNF-α...
Natural products have shown neuroprotective effects in neurodegenerative conditions. Naringenin is a natural flavonoid with various pharmacological activities especially antioxidant, anti-inflammatory and properties. We investigated the of naringenin on anesthetic propofol-induced impacts neonatal mouse brain development consequent long-term neurocognitive during adulthood.Female C57Bl/6 male CD-1 mice postnatal day 7 (P7) pups were exposed to propofol (2.5 mg/kg) (50 mg/kg). Mice allowed...