A5086194994- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Magnesium Alloys: Properties and Applications
- Sleep and Wakefulness Research
- Microstructure and mechanical properties
- Sleep and related disorders
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthopaedic implants and arthroplasty
- Aluminum Alloys Composites Properties
- Bone Tissue Engineering Materials
- Neuroscience and Neuropharmacology Research
Shantou University
2023
First Affiliated Hospital of Shantou University Medical College
2023
Central Institute of Mental Health
2023
Heidelberg University
2023
University Hospital Heidelberg
2023
First Affiliated Hospital of GuangXi Medical University
2018-2022
Guangxi Medical University
2018-2022
Fudan University
2015
Propofol is a commonly used general anesthetic for the induction and maintenance of anesthesia critical care sedation in children, which may add risk to poor neurodevelopmental outcome. We aimed evaluate effect propofol toward primary hippocampal neurons vitro possibly neuroprotective dexmedetomidine pretreatment, as well underlying mechanism.Primary were cultured 8 days pretreated with or without phosphorylation inhibitors prior exposure. Cell viability was measured using cell counting...
Propofol induces short- and long-term neurotoxicity. Our previous study showed that dexmedetomidine (Dex) can attenuate the propofol-induced acute neurotoxicity in rodents by enhancing PI3K/Akt signaling. However, whether treatment of young rats with Dex could protect them from induced propofol is unclear.Seven-day-old male Sprague Dawley were randomized injected intraperitoneally saline (100 μL, NS), mg/kg), (75 μg/kg), mg/kg) plus (25, 50 or 75 10% dimethyl sulfoxide (DMSO, 100 μL) TDZD-8...
Sleep deprivation (SD) causes a disturbance in the cognitive function of rats. While propofol has powerful sedative and hypnotic effect is an antioxidant, its on rats following SD remains unknown. The purpose this study was to explore protective effects excessive autophagy mitophagy hippocampus after SD.Adult male were intraperitoneally injected with 30 mg/kg 96 hours SD. Then we evaluated sleep deprived by Morris water maze. Transmission electron microscopy, Western blotting, PCR,...
Previous study has indicated that exposure to anesthesia in early development leads neuro-apoptosis and is followed by longterm cognitive dysfunction.Given larger numbers of pregnant women currently receive during the first trimester, we wanted mimic this process vitro using mouse embryonic stem cells (mESCs) explore how different anesthetics affect self-renewal mESCs.In present study, mESCs were exposed dexmedetomidine, fentanyl, or remifentanil at clinical concentrations for 48 h.The then...
Millions of craniofacial surgeries are performed annually worldwide, and materials for bone repair widely needed. However, traditionally applied materials, such as titanium polymethylmethacrylate, have some shortcomings (limited malleability, material-based toxicity, non-biodegradability, lack bioactivity, etc.). Zinc based biodegradable metals possess superior mechanical properties, biodegradability, which make them promising candidate materials. Here, we successfully fabricated Zn-0.6Cu...