A5101780333- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Protein Tyrosine Phosphatases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Cancer survivorship and care
- Family Support in Illness
- Ferroptosis and cancer prognosis
- Sphingolipid Metabolism and Signaling
- Connexins and lens biology
- Ion Channels and Receptors
- Nuclear Receptors and Signaling
- Peroxisome Proliferator-Activated Receptors
Southern University of Science and Technology
2024
Yonsei University
2018-2023
Hubei University of Medicine
2021-2023
Sichuan University
2011-2023
Foshan Maternity and Child Health Care Hospital
2022
Southern Medical University
2022
St. Marianna University School of Medicine
2022
State Key Laboratory of Biotherapy
2021
University of California, San Francisco
2004-2016
Howard Hughes Medical Institute
2004-2016
Programmed cell death-1 (PD-1) is a coinhibitory receptor that suppresses T activation and an important cancer immunotherapy target. Upon by its ligand PD-L1, PD-1 thought to suppress signaling through the (TCR). By titrating in biochemical reconstitution system, we demonstrate co-receptor CD28 strongly preferred over TCR as target for dephosphorylation PD-1-recruited Shp2 phosphatase. We also show CD28, but not TCR, preferentially dephosphorylated response PD-L1 intact system. These results...
Delivery of effector proteins is a process widely used by bacterial pathogens to subvert host cell functions and cause disease. Effector delivery achieved elaborate injection devices can often be triggered environmental stimuli. However, export the L. pneumophila Icm/Dot Type IVB secretion system cannot detected until bacterium encounters target cell. We chemical genetics, perturbation strategy that utilizes small molecule inhibitors, determine mechanisms critical for activity. From...
The extent of receptor clustering determines which kinases mediate B cell signaling.
Abstract Aims We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) TLR4/Myd88 signaling pathway. Methods C57 mice were randomly divided into blank, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced artemisinin‐treated groups. Clinical symptoms, number dopaminergic (DAergic) neurons in substantia nigra, microglial activation compared among three Subsequently, BV‐2 pathway component expression MPP + ‐treated,...
E2F plays critical roles in cell cycle progression by regulating the expression of genes involved nucleotide synthesis, DNA replication, and control. We show that combined loss E2F1 E2F2 mice leads to profound cell-autonomous defects hematopoietic development multiple lineages. mutant erythroid maturation are comparable with those observed patients megaloblastic anemia. Importantly, E2F1/E2F2 double-knockout (DKO) appear result from impeded S phase progenitor cells. During DKO B-cell...
Abstract Programmed death-1 (PD-1) is a co-inhibitory receptor that suppresses T cell activation and an important cancer immunotherapy target. Upon by its ligand PD-L1, PD-1 thought to suppress signaling through the (TCR). Here, titrating strength of in both biochemical reconstitution systems cells, we demonstrate coreceptor CD28 strongly preferred over TCR as target for dephosphorylation PD-1- recruited Shp2 phosphatase. We also show colocalizes with costimulatory plasma membrane...
Neuroinflammation is one of the most common pathological outcomes in various neurological diseases. A growing body evidence suggests that neuroinflammation plays a pivotal role pathogenesis epileptic seizures. Eugenol major phytoconstituent essential oils extracted from several plants and possesses protective anticonvulsant properties. However, it remains unclear whether eugenol exerts an anti-inflammatory effect to protect against severe neuronal damage induced by In this study, we...
Increased airway smooth muscle (ASM) contractility and the development of hyperresponsiveness (AHR) are cardinal features asthma, but signaling pathways that promote these changes poorly understood. Tyrosine phosphorylation is tightly regulated by opposing actions protein tyrosine kinases phosphatases, little known about whether phosphatases influence AHR. Here, we demonstrate genetic inactivation receptor-like phosphatase J (Ptprj), which encodes CD148, protected mice from increased AHR in...
Abstract CD148 is a receptor-like protein tyrosine phosphatase expressed on wide variety of cell types. Through the use flow cytometry and immunofluorescence microscopy tissue sections, we examined expression multiple murine hemopoietic lineages. We found that moderately during all stages B development in bone marrow, as well peripheral mature cells. In contrast, thymocytes T cells substantially lower. However, stimulation through TCR leads to an increase expression. This up-regulation can...
Background: Due to high tumor heterogeneity, breast cancer (BC) patients still suffer poor survival outcomes. YTHDF3 plays a critical role in the prognosis of BC patients. Hence, we aimed construct YTHDF3-based model for prediction overall (OS) and sensitivity therapeutic agents Methods: Based on The Cancer Genome Atlas (TCGA, https://portal.gdc.cancer.gov/) database, obtained patients' data (n = 999) with expression profiles. association between 5-year OS was determined via Cox proportional...
The importance of apoptosis during the process inhibiting tumorigenesis has been recognized. role BH3-only proapoptotic protein Bcl-2-associated death (BAD) in tumor growth remains controversial. aim this study was to explore BAD lung cancer cells. Our showed that expression upregulated A549 cells by a recombinant lentivirus overexpressing BAD. In vitro, overexpression significantly inhibited cell proliferation and induced assays, respectively. effect on studied xenograft nude mice results...
Abstract The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of (HERC2 ) recognizes mimetic Nt-R cargo degradation signal. NMR titration experiments mutagenesis results reveal peptide occupies well-defined binding site comprising negatively charged aspartic acids. We report crystal structure DOC is adjacent conformational rearrangement in protein may occur when two domains...