A5100444222- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Kruppel-like factors research
- Vascular Malformations Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and genetic disorders
- Spinal Cord Injury Research
- Mycobacterium research and diagnosis
- Bioactive Natural Diterpenoids Research
- Amyotrophic Lateral Sclerosis Research
- Smart Materials for Construction
- Bioactive natural compounds
- Cancer-related gene regulation
- Spinal Hematomas and Complications
- Moyamoya disease diagnosis and treatment
- PI3K/AKT/mTOR signaling in cancer
- Nerve injury and regeneration
- Chromatin Remodeling and Cancer
- Adenosine and Purinergic Signaling
Hubei University of Medicine
2017-2024
Wuhan University
2012-2023
Nanjing Drum Tower Hospital
2022
Tongji Hospital
2002
Huazhong University of Science and Technology
2002
Abstract Neuroinflammation is a secondary response following ischemia stroke. Arginine non-essential amino acid that has been shown to inhibit acute inflammatory reaction. In this study we show arginine treatment decreases neuronal death after rat cerebral ischemia/reperfusion (I/R) injury and improves functional recovery of stroke animals. We also suppresses in the ischemic brain tissue cultured microglia OGD insult. further provide evidence levels HIF-1α LDHA are increased I/R prevents...
Abstract Aims We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) TLR4/Myd88 signaling pathway. Methods C57 mice were randomly divided into blank, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced artemisinin‐treated groups. Clinical symptoms, number dopaminergic (DAergic) neurons in substantia nigra, microglial activation compared among three Subsequently, BV‐2 pathway component expression MPP + ‐treated,...
NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of activity NMDARs in clinical relevant conditions, we tested effect glycine, co-agonist NMDARs, rat middle cerebral artery occlusion (MCAO), an animal model ischemia-reperfusion injury after animals were injected with channel blocker MK-801 and glycine antagonist strychnine. We show reduces infarct volume brain ischemic stroke...
We and others have shown that inhibiting phosphatase tensin homolog deleted on chromosome 10 (PTEN) or activating ERK1/2 confer neuroprotection. As bisperoxovanadium compounds are well-established inhibitors of PTEN, we designed bisperoxovandium (pyridin-2-squaramide) [bpV(pis)] determined whether how bpV(pis) exerts a neuroprotective effect in cerebral ischaemia-reperfusion injury.Malachite green-based assay was used to measure PTEN activity. A western blot the phosphorylation level Akt...
Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] is a commercially available PTEN inhibitor. Previous studies from us and others have shown that bpV(pic) confers neuroprotection in cerebral ischemia injury. We set up to determine whether ERK 1/2 activation plays role bpV(pic)-induced neuroprotective effect found the phosphorylation levels of Akt (p-AKT) ERK1/2 (p-ERK 1/2) were down-regulated after ischemia–reperfusion The injection injury not only increased level p-AKT but also p-ERK 1/2....
Abstract Glioblastoma ( GBM ) is the most aggressive glioma in brain. Recurrence of almost inevitable within a short term after tumor resection. In retrospective study 386 cases collected between 2013 and 2016, we found that recurrence mainly occurs deep brain regions, including basal ganglia, thalamus, corpus callosum. But mechanism underlying this phenomenon not clear. Previous studies suggest neuroligin‐3 NLGN 3) necessary for growth. Our results show levels 3 cortex are higher than those...
Abstract Ischemic insult stimulates proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) after stroke. However, only a fraction NSC‐derived neuroblasts from SVZ migrate toward poststroke brain region. We have previously reported that direct‐current stimulation guides NSC migration cathode vitro. Accordingly, we set up new method transcranial (tDCS), which cathodal electrode is placed on ischemic hemisphere and anodal contralateral rats subjected to ischemia–reperfusion...
Glycine is known to protect against neuronal death. However, the underlying mechanism remains be elucidated. The microRNA-301a involved in both biological and pathological processes. But it not whether has a neuroprotective property. In this study, we aimed determine glycine-induced neuroprotection requires microRNA-301a-dependent signaling.We provided first evidence that glycine increased expression of cultured rat cortical neurons protected death through up-regulation after oxygen-glucose...
DJ-1 (also called PARK7) is a multifunctional redox-sensitive protein that protective against oxidative stress-induced cell death. TAR DNA-binding 43 (TDP-43) major component of pathological inclusions in amyotrophic lateral sclerosis and frontotemporal dementia. Reducing aberrant aggregation TDP-43 potential approach to prevent To investigate whether might inhibit exert effect injury, we tested the level subcellular localization SH-SY5Y cells transfected with wild-type DJ-1, mutant (L166P)...
Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that bpV[pic] inhibits PTEN activates ERK 1/2 respectively. In this study, we examined the effect in rat ICH model vivo hemin-induced injury cortical cultures. The was created by injecting autologous blood into striatum intraperitoneally injected. effects were evaluated neurological tests, Fluoro-Jade C (FJC) staining Nissl staining. demonstrate attenuates ICH-induced...
Background: We and others have previously demonstrated that glycine is neuroprotective in cerebral ischemia-reperfusion injury. But has low permeability to the blood-brain barrier (BBB). To deliver into ischemic brain confer neuroprotection, we designed a novel glycine-containing BBB-permeable tripeptide, H-glycine-cysteine-phenylalanine-OH (GCF). Methods: For synthesis of GCF, phenylalanine was included increase BBB tripeptide. Cysteine conjugated with enable release from GCF. With use...
Background: The authors have recently designed a new compound bisperoxovandium (pyridin-2-squaramide) [bpV(pis)] and verified that bpV(pis) confers neuroprotection through suppressing PTEN activating ERK1/2, respectively. Intracerebral hemorrhage (ICH) is the second most common cause of stroke has severe clinical outcome. In this study, we investigate effect in ICH model both vivo vitro. Materials methods: novel drug was synthesized Faculty Pharmacy, Wuhan University School Medicine. An...
Abstract Studies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative vanadate, is well-established inhibitor PTEN. However, its function islimited due to general inadequacy in penetrating cell membranes. Mxene(Ti 3 C 2 T x ) novel two-dimensional lamellar nanomaterial with an excellent ability penetrate membrane. Yet, effects this nervous system...
In a frequent period of extreme climate events, accidents caused by variable weather condition and influence to power grid security are increasing. this paper, regression model between elements ice thickness is established based on micro-climate condition. Ice each icing process in the district acquired from data recent years corrected altitude regional geographic feature. Gumbel distribution functions constructed annual maximum crash probabilities transmission lines calculated their design...
Objective To explore the preliminary experience of a one-stage hybrid operating room (OR) in cerebrovascular surgery.Methods A total 23 patients [9 male,mean age:(40.0±11.2) years] underwent approach OR from September 2012 to December 2013,were chosen our study.Craniotomy and percutaneous intervention these were performed single session.Their clinical data retrospectively analyzed.Results Thirty-one times digital subtraction angiography (DSA) was all patients,and 15 diagnosed as having...
Objective To investigate the patterns of clinical manifestations, diagnosis, treatment and surgical outcomes spinal epidural dumbbell-shaped cavernous hemangiomas. Methods Between June 2008 November 2013, a series 9 patients with symptomatic hemangiomas were surgically managed in Beijing Tiantan Hospital, which diagnoses pathologically verified. The radiographic features, modality prognosis retrospectively reviewed. attention was specially paid to differential diagnosis for other...
ObjectiveCapillary hemangioma is a benign vascular malformation that usually encountered in soft-tissue. Rarely, it may occur the neuraxis, and spinal capillary (SCH) rare var...
Vascular dementia is the second most common type of dementia, yet no effective treatment for it exists. Akt and Erk1/2 signaling pathways are involved in neuronal survival. It has been reported that bisperoxovanadium (pyridin-2-squaramide), a novel squaramide compound, protects against cerebral ischemia injury via activation Erk1/2. Here, potential neuroprotective effect shown first time model vascular induced 6-month-old male Sprague-Dawley rats by two-vessel occlusion applied to...