A5035104790- Antibiotic Resistance in Bacteria
- Intracerebral and Subarachnoid Hemorrhage Research
- NF-κB Signaling Pathways
- Endodontics and Root Canal Treatments
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Advanced Glycation End Products research
- PI3K/AKT/mTOR signaling in cancer
- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- MicroRNA in disease regulation
- Dental Trauma and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Ophthalmology and Eye Disorders
- Sperm and Testicular Function
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Health disparities and outcomes
Beijing Academy of Agricultural and Forestry Sciences
2021-2025
Jishou University
2025
Chinese Center For Disease Control and Prevention
2025
Xiangyang Hospital of Traditional Chinese Medicine
2025
Huazhong University of Science and Technology
2025
Yunnan University
2025
Fujian Medical University
2024
Wuhan University
2009-2024
Renmin Hospital of Wuhan University
2009-2024
University of California, San Francisco
2022-2024
Acyl‑CoA synthetase long‑chain family member 4 (ACSL4) is a of the long chain acyl‑CoA proteins, which have recently been shown to serve an important role in ferroptosis. Previous studies suggested that ferroptosis involved occurrence glioma; however, ACSL4 glioma remains unknown. In present study, reduction human tissues and cells was observed. Subsequently, it demonstrated expression also downregulated cells. A inhibitor inducer were used investigate effects on viability. The results...
A new pathway of testosterone (T) action in Sertoli cells was recently identified that may be required to support spermatozoa production (spermatogenesis) and fertility. Specifically, T acts via the androgen receptor (AR) rapidly activate MAPK cascade cAMP response element-binding protein (CREB) transcription factor cells. In further characterizing signaling transduces actions, we now find a population AR is localized plasma membrane associates with Src kinase after stimulation. addition,...
By shifting the constituents of signalosomes, T cells may stimulate distinct pathways in response to antigens.
Incidences of nosocomial infections mediated by New Delhi metallo-β-lactamase (NDM) enzyme-producing Enterobacterales are increasing globally, resulting in a great burden to public health. The carbapenem-resistant (CRE) were collected from Henan, China during 2013-2016. blaNDM-positive strains characterized using PCR, antimicrobial susceptibility testing, conjugation assay, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blot, whole-genome sequencing (WGS), and...
Background The purpose of this study was to investigate the diagnostic performance neutrophil percentage-to-albumin ratio (NPAR) for predicting stroke-associated pneumonia (SAP) and functional outcome in patients with intracerebral hemorrhage (ICH). Methods We analyzed our prospective database consecutive ICH who were admitted First Affiliated Hospital Chongqing Medical University from January 2016 September 2021. included subjects a baseline computed tomography available complete NPAR count...
Abstract Neuroinflammation is a secondary response following ischemia stroke. Arginine non-essential amino acid that has been shown to inhibit acute inflammatory reaction. In this study we show arginine treatment decreases neuronal death after rat cerebral ischemia/reperfusion (I/R) injury and improves functional recovery of stroke animals. We also suppresses in the ischemic brain tissue cultured microglia OGD insult. further provide evidence levels HIF-1α LDHA are increased I/R prevents...
Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional regulation, hijacked by diverse viruses to facilitate viral replication. However, its regulatory effect antiviral innate immunity remains unclear. We found that DDX5 interacts with the N 6 -methyladenosine (m6A) writer METTL3 regulate methylation of mRNA through affecting m6A METTL3–METTL14 heterodimer complex. Meanwhile, promoted modification and nuclear export transcripts DHX58, p65, IKKγ binding conserved...
Xanthomonas campestris pathovar (Xcc) is the causal agent of black rot disease crucifers worldwide. The molecular genetic diversity and host specificity Xcc are poorly understood.We constructed a microarray based on complete genome sequence strain 8004 investigated by array-based comparative hybridization analyses 18 virulent strains. results demonstrate that core comprising 3,405 4,186 coding sequences (CDSs) spotted array conserved flexible gene pool with 730 CDSs absent/highly divergent...
Testosterone and FSH act in synergy to produce the factors required maximize production of spermatozoa male fertility. However, molecular mechanisms by which these hormones support spermatogenesis are not well established. Recently, we identified a nonclassical mechanism testosterone signaling cultured rat Sertoli cells. We found that binding androgen receptor recruits activates Src tyrosine kinase. then causes activation epidermal growth factor receptor, results phosphorylation ERK MAPK...
• PTEN, TLR4, NF-κB and NLRP3 are increased in the hippocampus of PSD mice. PTEN suppression downregulates mouse . Exercise ameliorates via PTEN/TLR4/NF-κB/NLRP3 signaling.
ABSTRACT Marek’s disease virus (MDV), a highly contagious and oncogenic avian alphaherpesvirus, establishes latent infection primarily in CD4 + T cells. Latent infections are necessary for both persistent lifelong MDV viral tumorigenesis. MicroRNAs (miRNAs) play critical roles as post-transcriptional regulators of infections. However, the role miRNAs regulating latency remains unclear. In this study, we found that an MDV-encoded miRNA, miR-M6-5p, inhibited lytic replication vitro by...
Aims/Background Coronary angiography is a widely used invasive approach for diagnosing coronary atherosclerotic heart disease (CHD). However, carotid ultrasound may predict CHD by assessing atherosclerosis. Therefore, this study explores the predictive significance of parameters in accurately artery disease. Methods This retrospective analysis included 82 patients who underwent scans at Funan County Hospital Traditional Chinese Medicine, China, between July 2021 and February 2024. Based on...
Epidural analgesia is frequently used to alleviate labour pain, and dietary management during of crucial importance. Therefore, this study investigates the impact epidural for on gastric emptying in parturient women. A total 70 full-term women were recruited divided into two groups: group (LA, n = 35) non-epidural (NA, 35). Fasting antrum cross-sectional area (CSA0) was assessed using B-mode ultrasonography at T0. Both groups then consumed 300 g millet porridge (600KJ). Post-meal, CSAs...
The PI ‐3 kinase ( 3 K ) pathway is critical for T ‐cell development and activation. Several negative regulators of this have already been described characterized: the lipid phosphatases SHIP , inositol polyphosphate‐4‐phosphatase, type II (INPP4B), phosphatase tensin homolog PTEN ), latter which are tumor suppressors. PIK IP 1 (PI3K interacting protein 1) a recently transmembrane that has ability to bind catalytic p110 prevent its activation by p85 family adaptor proteins. Thus far, nothing...