A5050952361- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Maternal and fetal healthcare
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Medication Adherence and Compliance
- Natural Antidiabetic Agents Studies
- Growth Hormone and Insulin-like Growth Factors
- Adolescent and Pediatric Healthcare
- Artificial Intelligence in Healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Digestive system and related health
- Birth, Development, and Health
Sun Yat-sen University
2015-2025
Third Affiliated Hospital of Sun Yat-sen University
2015-2025
Key Laboratory of Guangdong Province
2017-2020
Rutgers, The State University of New Jersey
2002
Rutgers New Jersey Medical School
2002
Albert Einstein College of Medicine
1994-1996
The physiological role of insulin-like growth factor (IGF) II (IGF-II) in adult humans is poorly understood. Rather high levels IGF-II persist human serum, whereas, rodents, are very low. To investigate the and carcinogenic effects persistently elevated adults, we have produced two lines transgenic mice which (20- or 30-fold increase above normal) maintained blood. transgene driven by major urinary protein promoter, it highly expressed liver perputial glands both lines. smaller than...
Background: Previous studies show that the use of do-it-yourself artificial pancreas system (DIYAPS) may be associated with better glycemic control characterized by improved estimated hemoglobin A1c (eHbA1c) and time in range among adults type 1 diabetes (T1D). However, few have demonstrated changes laboratory-measured HbA1c, which is a more accepted index for control, after using DIYAPS. Methods: This retrospective before-after study approaching patients who reported self-use AndroidAPS....
Objective As an emerging technology, Android-based open-source closed-loop system also called Android Artificial Pancreas System (AAPS), has been increasingly validated by evidence for its effectiveness in improving glycaemic outcomes, positioning it as a crucial option managing type 1 diabetes (T1D). However, there are still only few studies examining the experiences of using AAPS, and relevant qualitative have not conducted Asia so far. This study aimed to explore opinions adult patients...
The study aimed to compare glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus (T1DM) using multiple daily injection therapy (MDI) continuous subcutaneous insulin infusion (CSII) of treated long-acting or neutral protamine Hagedorn (NPH).
Concerning the related factors for kidney disease and high chronic (CKD) progression risk, there is still a lack of study in adult-onset type 1 diabetes mellitus (T1DM) patients from China. Four hundred eighty-one T1DM Guangdong translational medicine were included. Logistic regression analysis (Forward: LR) was utilized to identify glycemic- nonglycemic-related associated with moderate albuminuria, severe mildly reduced estimated glomerular filtration rate (eGFR), decreased eGFR, CKD...
Depression is the most common psychological disorder in patients with type 1 diabetes (T1D). However, characteristics of microbiota and metabolites these remain unclear. This study aimed to investigate microbial metabolomic profiles identify novel biomarkers for T1D depression.
Diabetic ketoacidosis (DKA) and severe hypoglycaemia are common acute complications of type 1 diabetes mellitus (T1DM). This study aimed to determine the incidence of, risk factors for, these in Chinese patients with established T1DM.This cross-sectional recruited T1DM from 16 centres Guangdong Province, China. Incidence rates were expressed as episodes/100 patient-years. Regression models identified for occurrence recurrence secondary DKA hypoglycaemia.A total 611 (53.7% women) recruited....
Abstract Aims/hypothesis Insulin resistance (IR) is a risk factor to assess the development of micro‐ and macro‐vascular complications in type 1 diabetes (T1D). However, management adults with T1D limited by difficulty lacking simple reliable methods estimate insulin resistance. The aim this study was develop new model IR via clinical parameters T1D. Methods A total 36 adulthood onset (n = 20) or childhood 16) were recruited quota sampling. After an overnight infusion stabilize blood glucose...
Given that mutations related to maturity-onset diabetes of the young (MODY) are rarely found in Chinese populations, we aim characterize mutation spectrum MODY pedigrees.Maturity-onset candidate gene- or exome-targeted capture sequencing was carried out 76 probands from unrelated families fulfilling clinical diagnostic criteria for MODY. MAF <0.01 GnomAD ExAC database used filter significant variants. Sanger then validate findings. Function prediction by SIFT, PolyPhen-2 and PROVEAN CADD...
Glycaemic control is a great challenge in the management of type 1 diabetes mellitus (T1DM). There limited data concerning glycaemic among adults with T1DM. We used from Guangdong T1DM Translational Medicine Study to evaluate and its associated factors Chinese T1DM.This cross-sectional analysis included 827 participants who were 18 years age or older had been living for at least year. Participants HbA1c levels <7% compared against those ≥ 7%. A multivariate logistic regression model was...
Abstract Context Continuous glucose monitoring (CGM) overcomes the limitations of glycated hemoglobin (HbA1c). Objective This study aimed to investigate relationship between CGM metrics and laboratory HbA1c in pregnant women with type 1 diabetes. Methods An observational enrolled diabetes who wore devices during pregnancy postpartum from 11 hospitals China January 2015 June 2019. data were collected calculate time range (TIR), above (TAR), below (TBR), glycemic variability parameters....
BACKGROUND In patients with type 2 diabetes mellitus (T2DM), the risk of hypoglycemia also occurs in at a time-in-range (TIR) > 70%. The hemoglobin glycation index (HGI) is considered best single factor for predicting hypoglycemia, and offers new perspectives individualized treatment well-controlled blood glucose levels that are easily ignored clinical settings. AIM To investigate relationship between HGI implications on T2DM TIR METHODS All participants underwent 7-days continuous...
Abstract Background A lack of demographic and clinical data hinders efforts health care providers in China to support patients with type 1 diabetes mellitus (T1D). Therefore, the aim present retrospective study was provide an overview characteristics Chinese T1D. Methods Hospital medical records T1D (diagnosed between January 2000 December 2011) 105 secondary tertiary hospitals across Guangdong province were reviewed. Data collected on patient age at diagnosis, presentations onset, physical...
OBJECTIVE To investigate the effect on pregnancy outcome of integrating a comprehensive management plan for patients with type 1 diabetes (T1D) into World Health Organization universal maternal care infrastructure. RESEARCH DESIGN AND METHODS A preconception-to-pregnancy women T1D was implemented in 11 centers from 8 Chinese cities 2015 to 2017. Sequential eligible pregnant (n = 133 out 137 initially enrolled) and singleton pregnancies attending these formed prospective cohort. The main...
Purpose: Smartphones have received increasing attention and achieved positive outcomes in diabetes intervention. The widespread use of WeChat China provides an opportunity for self-management practices patients with diabetes. Nevertheless, how to combine the strengths platform traditional medical strategy remains be explored. This study aimed evaluate efficacy a novel flash glucose monitoring device combined juvenile type 1 management. Patients Methods: A total 60 were randomly assigned into...
Peer support for diabetes has become convenient and interactive after the emergence of mobile health (mHealth). We aimed to evaluate association between engagement in peer through mHealth app glycemic control type 1 patients.This retrospective study included adults with who had joined community "TangTangQuan" since May 2018 at least year. "Like", "comment" "share" were major interaction indicators used assess support. The patients divided into four groups by quartile. primary outcome was...
Type 1 diabetes (T1D) progression is affected by circulating glutamic acid decarboxylase antibody (GADA) that persist for many years. This study aimed at investigating whether and how the gut microbiome its correlated metabolites change in T1D with presence of GADA.We used a radiobinding assay to measure GADA titers identify 49 patients GADA+ 52 GADA-. The fresh feces serum were analyzed using 16S rRNA gene sequencing GC/MS. Then compared between GADA- patients. association microbial...
N-myc2 and insulin-like growth factor II (IGF-II) are coordinately overexpressed in the great majority of altered hepatic foci, which earliest precancerous lesions observed liver woodchuck hepatitis virus carrier woodchucks, these genes continue to be hepatocellular carcinomas (HCCs). We have investigated function hepatocarcinogenesis by using a epithelial cell line (WC-3). WC-3 cells react positively with monoclonal antibody (12.8.5) against oval cells, suggesting lineage relationship...
Cellular replacement therapy for diabetes mellitus (DM) has received much attention. In this study, we investigated the effect of transplantation autologous bone marrow‑derived mesenchymal stem cells (ABMSCs) in streptozotocin (STZ)‑induced diabetic miniature pigs. Miniature pig BMSCs were cultured, labeled with superparamagnetic iron oxide (SPIO) and transplanted into pancreas pigs through targeted intervention. Blood glucose levels, intravenous oral tolerance test (OGTT), serum insulin,...
Our aim was to investigate the impact of glycemic variability (GV) on relationship between glucose management indicator (GMI) and laboratory glycated hemoglobin A1c (HbA1c).Adult patients with type 1 diabetes mellitus (T1D) were enrolled from five hospitals in China. All subjects wore iPro™2 system for 14 days before HbA1c measured at baseline, 3 months 6 months. Data derived sensor used calculate GMI GV parameters [standard deviation (SD), coefficient variation (CV), mean amplitude...