A5100418934- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Fungal and yeast genetics research
- Evolution and Genetic Dynamics
- Machine Learning in Bioinformatics
- Gene Regulatory Network Analysis
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- Computational Drug Discovery Methods
- Gene expression and cancer classification
- Genetic diversity and population structure
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant and animal studies
- Genomics and Rare Diseases
- Animal Genetics and Reproduction
- Genetic factors in colorectal cancer
- Air Quality and Health Impacts
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Chromatin Remodeling and Cancer
- Animal Behavior and Reproduction
Dalian Medical University
2023-2025
Chongqing Medical University
2023-2025
Second Affiliated Hospital of Chongqing Medical University
2023-2025
Sun Yat-sen University
2015-2024
Biocon (Switzerland)
2024
First Hospital of Qinhuangdao
2023
Bridge University
2022
Chongqing University
2020
Biocontrol (Brazil)
2019
Arizona State University
2016-2018
Abstract The life-threatening coronaviruses MERS-CoV, SARS-CoV-1 and SARS-CoV-2 (SARS-CoV-1/2) have caused will continue to cause enormous morbidity mortality humans. Virus-encoded noncoding RNAs are poorly understood in coronaviruses. Data mining of viral-infection-related RNA-sequencing data has resulted the identification 28 754, 720 3437 circRNAs encoded by SARS-CoV-2, respectively. MERS-CoV exhibits much more prominent ability encode all genomic regions than those SARS-CoV-1/2. Viral...
ABSTRACT Intellectual and developmental disabilities (IDD) are clinically genetically heterogeneous disorders of global concern. While whole exome sequencing (WES) is used to identify single nucleotide variants (SNVs) small insertions/deletions (Indels) in IDD patients, its detection rate limited. This study evaluated the value integrating copy number variation (CNV) analysis into traditional SNV/Indel based on trio‐WES. One hundred eighty seven patients with 140 families from southwest...
To further probe into whether swamp buffaloes were domesticated once or multiple times in China, this survey examined the mitochondrial DNA (mtDNA) Control Region (D-loop) diversity of 471 individuals representing 22 populations 455 Chinese and 16 river buffaloes. Phylogenetic analysis revealed that could be divided two distinct lineages, A B, which defined previously. Of lineage was predominant across all populations. For A, Southwestern buffalo possess highest genetic among three...
Glycaemic control is a great challenge in the management of type 1 diabetes mellitus (T1DM). There limited data concerning glycaemic among adults with T1DM. We used from Guangdong T1DM Translational Medicine Study to evaluate and its associated factors Chinese T1DM.This cross-sectional analysis included 827 participants who were 18 years age or older had been living for at least year. Participants HbA1c levels <7% compared against those ≥ 7%. A multivariate logistic regression model was...
Random X-chromosome inactivation (rXCI) is important for the maintenance of normal somatic cell functions in female eutherian mammals. The dynamics initiation has been widely studied by assessing embryonic stem differentiation vitro. To investigate phenomenon vivo, we applied RNA sequencing to single cells from embryos obtained a natural intercrossing two genetically distant mouse strains. Instead artificially assigning parental origin inactive X chromosome, chromosomes this study were...
Abstract Background Elucidating the effects of geography and selection on genetic variation is critical for understanding relative importance adaptation in driving differentiation identifying environmental factors underlying its occurrence. Adaptive common tree species, especially widely distributed long-lived species. Pseudotaxus chienii can occupy diverse habitats with heterogeneity thus provides an ideal material investigating process population adaptive evolution. Here, we characterize...
Background: Air pollution nowadays has seriously threatened the health of Chinese population, especially in vulnerable groups fetuses, infants and toddlers. In particular, effects air on children’s neurobehavioral development have attracted widespread attention. Moreover, early detection a sensitive period is very important for precise intervention disease. However, such studies focusing hyperactive behaviors susceptible window identification are currently lacking China. Objectives: The...
Individuals with autism put a heavy demand on medical services, and prevalence estimates are needed for the planning of such services. Screening in children has important implications individuals policy makers. This study aimed to estimate suspected Longhua District, Shenzhen, investigate risk factors autism. A cross-sectional was conducted Shenzhen October 2014. total 141 kindergartens were approached consented participate current study. All who met inclusion criteria screened by using...
The central-marginal hypothesis predicts that geographically peripheral populations should exhibit reduced genetic diversity and increased differentiation than central due to smaller effective population size stronger geographical isolation. We evaluated these predictions in the endangered conifer Taxus wallichiana var. mairei. Eight plastid simple sequence repeats (cpSSRs) were used investigate variation 22 of mairei, encompassing nearly its entire distribution range. Low levels detected...
Pleiotropy, the phenomenon in which a single gene influences multiple traits, is fundamental concept genetics. However, evolutionary mechanisms underlying pleiotropy require further investigation. In this study, we conducted parallel knockouts targeting 100 transcription factors 2 strains of Saccharomyces cerevisiae. We systematically examined and quantified pleiotropic effects these on expression levels for each factor. Our results showed that knockout generally affected genes both strains,...
Abstract An important topic in systems biology is the reverse engineering of regulatory mechanisms through reconstruction context-dependent gene networks. A major challenge to identify genes and regulations specific a condition or phenotype, given that processes are highly connected such response typically accompanied by numerous collateral effects. In this study, we design multi-layer approach able reconstruct condition-specific their regulation an integrative analysis large-scale...
The diverse, specialized genes in today's lifeforms evolved from a common core of ancient, elementary genes. However, these did not evolve individually: gene expression is controlled by complex network interactions, and alterations one may drive reciprocal changes its proteins' binding partners. We show that the topology leukemia regulatory strongly coupled with evolutionary properties. Slowly-evolving ("cold"), old tend to interact each other, as do rapidly-evolving ("hot"), young genes,...
In mammals, testis determination is under the control of sex-determining gene SRY. This Y-linked encodes a protein with DNA binding domain similar to those found in high-mobility-group proteins. Here we report cloning and sequences SRY genes yak Chinese native cattle. Our data show that Bovidae are less divergent, especially coding 3' regions.
Complex diseases such as cancer are usually the result of a combination environmental factors and one or several biological pathways consisting sets genes. Each pathway exerts its function by delivering signaling through gene network. Theoretically, is supposed to have robust topological structure under normal physiological conditions. However, pathway's could be altered some pathological condition. It well known that network includes small number well-connected hub nodes large non-hubs. In...
Abstract Fisher’s fundamental theorem of natural selection predicts no additive variance fitness in a population. Consistently, studies variety wild populations show virtually narrow-sense heritability (h2) for traits important to fitness. However, counterexamples are occasionally reported, calling deeper understanding on the evolution variance. In this study, we propose adaptive divergence followed by population admixture as source genetic evolutionarily traits. We experimentally tested...
Abstract Genic functions have long been confounded by pleiotropic mutational effects. To understand such genetic effects, we examine HAP4, a well-studied transcription factor in Saccharomyces cerevisiae that forming tetramer with HAP2, HAP3 and HAP5. Deletion of HAP4 results highly gene expression responses, some which are clustered related cellular processes (clustered effects) while most distributed randomly across diverse (distributed effects). Strikingly, the effects account for much...
Heart failure (HF) is a syndrome with multiple clinical symptoms resulting from damage to the heart's structure and/or function various pathogenic factors, which has developed as one of most severe threats human health. Approximately 13% genes and about 8% proteins contained in heart are rhythmic, could lead HF if disrupted. Herein, we aimed identify circadian rhythms-related hub potential biomarkers contributing identification treatment HF.Expression data ischemic dilated cardiomyopathy...
This paper proposes a novel hybrid GA/SVM method that can predict the interactions between proteins intermediated by protein-domain relations. Firstly, we represented protein domains contained inside, which consider effects of domain duplication. To simulate combination different domains, transformation composition was taken subsequently. Further, genetic algorithm used to seek optimized transformation, had been adopted as input vector predictor constructed using support machines method....