A5082070398- Fungal and yeast genetics research
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Endoplasmic Reticulum Stress and Disease
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Bioinformatics and Genomic Networks
- Evolutionary Game Theory and Cooperation
- Nematode management and characterization studies
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Mitochondrial Function and Pathology
- Fermentation and Sensory Analysis
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Chromatin Dynamics
- Plant Disease Resistance and Genetics
University of Michigan
2020-2024
Sun Yat-sen University
2016-2020
Biocontrol (Brazil)
2019
Abstract While the underlying genetic changes have been uncovered in some cases of adaptive evolution, lack a systematic study prevents general understanding genomic basis adaptation. For example, it is unclear whether protein-coding or noncoding mutations are more important to evolution and adaptations different environments brought by distributed diverse genes biological processes concentrated core set. We here perform laboratory 3360 Saccharomyces cerevisiae populations 252 varying levels...
Essential genes refer to those whose null mutation leads lethality or sterility. Theoretical reasoning and empirical data both suggest that the fatal effect of inactivating an essential gene can be attributed either loss indispensable core cellular function (Type I), gain side effects after losing dispensable periphery II). In principle, inactivation Type I rescued only by re-gain functions, whereas II could a further another eliminate otherwise effects. Because such loss-of-function...
Phenotypic plasticity plays a key role in adaptation to fluctuating environments. However, its evolutionary significance remains debated, with conflicting views on whether it is actively maintained by natural selection or neutral consequence of molecular constraints. In this study, we investigate the gene expression yeast populations exposed antibiotic and osmotic stress. Using mutation accumulation (MA) lines separate effects from genetic drift, compare responses (referred as plastic...
Abstract Due to epistasis, the same mutation can have drastically different phenotypic consequences in individuals. This phenomenon is pertinent precision medicine as well antimicrobial drug development, but its general characteristics are largely unknown. We approach this question by genome-wide assessment of gene essentiality polymorphism 16 Saccharomyces cerevisiae strains using transposon insertional mutagenesis. Essentiality observed for 9.8% genes, most which had repeated switches...
Genetic assimilation is the evolutionary process by which an environmentally induced phenotype becomes genetically encoded and constitutive. has been proposed as a concluding step in environmental adaptation, but its prevalence not systematically investigated. Analyzing transcriptomic data collected upon reciprocal transplant, we address this question experimental evolution, domestication, or natural evolution of seven diverse species. We find that genetic environment-induced gene expression...
Abstract Compared with asexual reproduction, sex facilitates the transmission of transposable elements (TEs) from one genome to another, but boosts efficacy selection against deleterious TEs. Thus, theoretically, it is unclear whether has a positive net effect on TE’s proliferation. An empirical study concluded that at root evolutionary success because yeast TE load was found decrease rapidly in approximately 1,000 generations not sexual experimental evolution. However, this finding...
Abstract Genic functions have long been confounded by pleiotropic mutational effects. To understand such genetic effects, we examine HAP4, a well-studied transcription factor in Saccharomyces cerevisiae that forming tetramer with HAP2, HAP3 and HAP5. Deletion of HAP4 results highly gene expression responses, some which are clustered related cellular processes (clustered effects) while most distributed randomly across diverse (distributed effects). Strikingly, the effects account for much...
Abstract Essential genes refer to those whose null mutation leads lethality or sterility. We propose that the fatal effect of inactivating an essential gene can be attributed either loss indispensable core cellular function (type I), gain side effects after losing dispensable periphery II). In principle, inactivation type I rescued only by regain functions, whereas II could a further another eliminate otherwise effects. Because such loss-of-function rescuing mutations may occur...
Abstract Genic functions have long been confounded by pleiotropic mutational effects. To understand such genetic effects, we examine HAP4, a well-studied transcription factor in Saccharomyces cerevisiae that forming tetramer with HAP2, HAP3, and HAP5. Deletion of HAP4 results highly gene expression responses, some which are clustered related cellular processes (clustered effects) while most distributed randomly across diverse (distributed effects). Strikingly, the effects account for much...