A5102910308- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Vector-Borne Animal Diseases
- Data-Driven Disease Surveillance
- Bacteriophages and microbial interactions
- Cutaneous Melanoma Detection and Management
- AI in cancer detection
- Galectins and Cancer Biology
- Nonmelanoma Skin Cancer Studies
- Clostridium difficile and Clostridium perfringens research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Gut microbiota and health
- Data Mining Algorithms and Applications
- Scientific Computing and Data Management
- CRISPR and Genetic Engineering
- Bamboo properties and applications
- Advanced Clustering Algorithms Research
- Animal Virus Infections Studies
- Wood Treatment and Properties
- Viral Infections and Immunology Research
BGI Group (China)
2025
BGI Research
2025
Alibaba Group (China)
2020-2024
First Affiliated Hospital of GuangXi Medical University
2023
Hunan University
2014-2022
Sansure Biotech (China)
2019-2020
Abstract The life-threatening coronaviruses MERS-CoV, SARS-CoV-1 and SARS-CoV-2 (SARS-CoV-1/2) have caused will continue to cause enormous morbidity mortality humans. Virus-encoded noncoding RNAs are poorly understood in coronaviruses. Data mining of viral-infection-related RNA-sequencing data has resulted the identification 28 754, 720 3437 circRNAs encoded by SARS-CoV-2, respectively. MERS-CoV exhibits much more prominent ability encode all genomic regions than those SARS-CoV-1/2. Viral...
Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on bacterial collection constructed our previous studies, we founded Bifidobacterium adolescentis AF91-08b2A has potential beneficial function. We designed cohort genomic animal experiments to further explore probiotic function its therapeutic effect IBD. The depletion B. individuals with IBD suggested significance for intestinal health. Genomic...
Abstract African swine fever virus (ASFV) poses serious threats to the pig industry. The multigene family (MGF) proteins are extensively distributed in ASFVs and generally classified into five families, including MGF-100, MGF-110, MGF-300, MGF-360 MGF-505. Most MGF proteins, however, have not been well characterized within each family. To bridge this gap, study first 31 groups based on protein sequence homology network clustering. A web server for classifying was established kept available...
Receptors on host cells play a critical role in viral infection. How phages select receptors is still unknown.Here, we manually curated high-quality database named phageReceptor, including 427 pairs of phage-host receptor interactions, 341 unique species or sub-species and 69 bacterial species. Sugars proteins were most widely used by as receptors. The usage Gram-positive bacteria was different from that Gram-negative bacteria. Most protein located the outer membrane. phage (PPRs) highly...
Newly emerging influenza viruses keep challenging global public health. To evaluate the potential risk of viruses, it is critical to rapidly determine phenotypes including antigenicity, host, virulence and drug resistance.Here, we built FluPhenotype, a one-stop platform determinate A viruses. The input FluPhenotype complete or partial genomic/protein sequences output presents five types information about viruses: (i) sequence annotation gene protein names as well open reading frames, (ii)...
Abstract Motivation Previously, we developed a computational model to identify genomic co-occurrence networks that was applied capture the coevolution patterns within genomes of influenza viruses. To facilitate easy public use this model, an R package ‘cooccurNet’ is presented here. Results includes functionalities construction and analysis residues (e.g. nucleotides, amino acids SNPs) network. In addition, new method for measuring coevolution, defined as residue score (RCOS), proposed...
Timely surveillance of the antigenic dynamics influenza virus is critical for accurate selection vaccine strains, which important effective prevention viral spread and infection.Here, we provide a computational platform, called PREDAC-H3, human A(H3N2) based on sequence surface protein hemagglutinin (HA). PREDAC-H3 not only determines variants cluster (grouped similar antigenicity) to belongs, HA sequences, but also allows visualization spatial distribution temporal clusters viruses isolated...
Diagnosing malignant skin tumors accurately at an early stage can be challenging due to ambiguous and even confusing visual characteristics displayed by various categories of tumors. To improve diagnosis precision, all available clinical data from multiple sources, particularly images, dermoscopy medical history, could considered. Aligning with practice, we propose a novel Transformer model, named Remix-Former++ that consists image branch, metadata branch. Given the unique inherent in...
Influenza (Flu) has caused and will continue to cause large morbidity mortality human society. Surveillance is critical for prevention control of it. Traditional methods influenza surveillance are based on hierarchical networks, which costly time-consuming. The Internet-based method a useful supplement traditional in surveillance. Here, we attempted predict the daily epidemics, represented as number influenza-like illness (ILI) cases, three representative provinces China (Beijing, Shanghai...
Clinical Data mining as an interdisciplinary subfield of computer science is becoming increasingly important in recent years. While, so far, there not a complete web based medical data analysis and platform. Weka one the most widely used tools with variety algorithms integrated. However, workbench, it can be integrated into specific business system. Also lots defects are detected our or other practitioner's daily usage such preprocessing functions can't satisfy actual needs. While badly...
Abstract Background hepatitis B is a risk factor for the development of intrahepatic cholangiocarcinoma. The prognosis HBV-related ICC remains to be further investigated. Aims To investigate clinical, pathological and imaging features cholangiocarcinoma virus-positive -negative patients. Methods Data from January 31, 2012 December 2019 138 patients were retrospectively analyzed. divided into group (group A[n=66]) virus-negative B[n=72]), well-to-moderately differentiated poorly according...
Abstract Motivation Receptors on host cells play a critical role in viral infection. How phages select receptors is still unknown. Results Here, we manually curated high-quality database named phageReceptor, including 355 pairs of phage-host receptor interactions, 280 unique species or sub-species and 64 bacterial species. Sugars proteins were most widely used by as receptors. The usage Gram-positive bacteria was different from that Gram-negative bacteria. Most protein located the outer...
Abstract African swine fever virus (ASFV) is a large and complex double-stranded DNA that poses serious threats to the pig industry. It well-accepted multigene family (MGF) proteins are extensively distributed in ASFVs generally classified into five families, including MGF-100, MGF-110, MGF-300, MGF-360 MGF-505. Most MGF proteins, however, have not been well characterized within each family. To bridge this gap, study first 35 groups based on protein sequence homology. A web server for...