A5045938742- Insect Pest Control Strategies
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Insect and Pesticide Research
- Monoclonal and Polyclonal Antibodies Research
- Insect Resistance and Genetics
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Spectroscopy and Chemometric Analyses
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Viral Infectious Diseases and Gene Expression in Insects
- Influenza Virus Research Studies
- Insect-Plant Interactions and Control
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Advanced Chemical Sensor Technologies
- RNA modifications and cancer
- Date Palm Research Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
Sichuan University
2015-2025
Liaoning Normal University
2025
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2025
Tsinghua University
2025
Academy of State Administration of Grain
2015-2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Sichuan Center for Disease Control and Prevention
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Deakin University
2023-2024
Protein-ligand blind docking is a powerful method for exploring the binding sites of receptors and corresponding poses ligands. It has seen wide applications in pharmaceutical biological researches. Previously, we proposed server, CB-Dock, which been under heavy use (over 200 submissions per day) by researchers worldwide since 2019. Here, substantially improved combining CB-Dock with our template-based engine to enhance accuracy site identification pose prediction. In benchmark tests, it...
Abstract Protein–ligand docking is an essential method in computer-aided drug design and structural bioinformatics. It can be used to identify active compounds reveal molecular mechanisms of biological processes. A successful usually requires thorough conformation sampling scoring, which are computationally expensive difficult. Recent studies demonstrated that it beneficial with the guidance existing similar co-crystal structures. In this work, we developed a protein–ligand method, named...
Motivation: Hydrophobic effect plays a pivotal role in most protein–ligand binding. State-of-the-art scoring methods usually treat hydrophobic free energy as surface tension, which is proportional to interfacial area for simplicity and efficiency. However, this treatment ignores the of molecular shape, has been found very important by either experimental or theoretical studies. Results: We propose new empirical function, named Cyscore. Cyscore improves prediction accuracy using novel...
In the electrical discharge plasma process, various chemical and physical processes can participate in removal of contaminants. this paper, that occur as a result are reviewed, their possible roles degradation contaminants discussed. Measurement methods for quantification important reactive species advantages shortcomings presented. Approaches on how to enhance diffusion solution examined. addition, formation typical different is compared.
Abstract Significant improvements have been made in the efficiency and accuracy of RNA 3D structure prediction methods during succeeding challenges RNA-Puzzles, a community-wide effort on assessment blind tertiary structures. The RNA-Puzzles contest has shown, among others, that development validation computational for fold strongly depend benchmark datasets comparison algorithms. Yet, there no systematic set or decoy structures available RNA, hindering standardization comparative tests...
Abstract Purple coneflower ( Echinacea purpurea (L.) Moench) is a popular native North American herbal plant. Its major bioactive compound, chicoric acid, reported to have various potential physiological functions, but little known about its biosynthesis. Here, taking an activity-guided approach, we identify two cytosolic BAHD acyltransferases that form intermediates, caftaric acid and chlorogenic acid. Surprisingly, unique serine carboxypeptidase-like acyltransferase uses as acyl donor...
Abstract Li metal batteries have been widely expected to break the energy‐density limits of current Li‐ion batteries, showing impressive prospects for next‐generation electrochemical energy storage system. Although much progress has achieved in stabilizing anode, electrode still lacks efficiency and safety. Moreover, a practical battery requires thickness‐controllable maximally balance density stability. However, due stickiness fragile nature metal, manufacturing ingot into thin electrodes...
This study proposes a recognition model for different drying methods of grain using hyperspectral imaging technology (HSI) and multivariate analysis. Fresh harvested samples were dried three methods: rotating ventilation drying, mechanical natural drying. Hyperspectral images the collected within 388–1065 nm band range. The spectral features extracted principal component analysis (PCA), while texture second-order probability statistical filtering. Partial least squares regression (PLSR)...
Abstract Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous machinery. However, susceptibility of for targeting TPD approaches, termed “degradability”, is largely unknown. Here, we developed machine learning model, model-free analysis degradability (MAPD), predict from features intrinsic targets. MAPD shows accurate performance in predicting kinases that are degradable compounds...
Abstract Auxin can inhibit or promote fruit ripening, depending on the species. Melting flesh (MF) peach (Prunus persica L. Batsch) cultivars produce high levels of ethylene caused by concentrations indole-3-acetic acid (IAA), which leads to rapid softening at late stage development. In contrast, due low IAA, stony hard (SH) does not soften and produces little ethylene. seems necessary trigger biosynthesis in fruit; however, mechanism is well understood. this study, we identified miRNA gene...
Abstract Objective Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction predominant pathological manifestation complication in diabetic retinopathy. N 6-methyladenosine (m6A) serves as most prevalent modification eukaryotic mRNAs. However, role m6A RNA still unclear. Methods RT-qPCR analysis western blot were conducted to detect change CCK-8 assay, transwell experiment, wound healing tube formation...
Previous studies showed that salicylic acid (SA)-deficient transgenic Arabidopsis expressing the salicylate hydroxylase gene NahG had a higher tolerance to moderate salt stress. SA may potentiate stress response of germination and growth seedlings by inducing reactive oxygen species (ROS). However, detailed mechanism for better adaption plants is largely unknown. In present study we found GSH/GSSG (glutathione/oxidized glutathione) ratio ASA/DHA (ascorbic acid/dehydroascorbate) in during be...
Steroidal compounds are some of the most prescribed medicines, being indicated for treatment a variety conditions including inflammation, heart disease, and cancer. Synthetic approaches to functionalized steroids important generating steroidal agents drug screening development. However, chemical activation is challenging because predominance inert, aliphatic C–H bonds in steroids. Here, we report engineering stable, highly active bacterial cytochrome P450 enzyme P450BM3 (CYP102A1) from...
The remarkable progress in cancer immunotherapy recent years has led to the heat of great development for therapeutic antibodies. Antibody numbering, which standardizes a residue index at each position an antibody variable domain, is important step immunoinformatic analysis. It provides equivalent comparison sequences or structures, particularly valuable modeling and engineering. However, due extremely high diversity sequences, antibody-numbering tools cannot work all cases. This article...
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets and TKI-resistant mutants proteasome-mediated degradation, resulting in suppression EGFR-driven growth. Reduced expression associated with poor clinical outcomes patients. Furthermore, glucose-regulated 94 (Grp94)...