A5101436145- Gut microbiota and health
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Herbal Medicine Research Studies
- Cytomegalovirus and herpesvirus research
- Digestive system and related health
- Infant Nutrition and Health
- Fungal Biology and Applications
- Infant Health and Development
- Energy Harvesting in Wireless Networks
- Herpesvirus Infections and Treatments
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Plant tissue culture and regeneration
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Tea Polyphenols and Effects
- Probiotics and Fermented Foods
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Coronary Interventions and Diagnostics
- Virus-based gene therapy research
Tianjin Medical University General Hospital
2018-2025
Tianjin Medical University
2018-2024
Penn State Milton S. Hershey Medical Center
2019-2024
Sichuan University
2021-2024
Pennsylvania State University
2015-2022
Tianjin Infectious Diseases Hospital
2021
Henan Agricultural University
2021
Cardiovascular Research Foundation
2020
Anhui Agricultural University
2018-2020
Heritage Christian University
2007
Background: Accumulating evidence shows that high fat diet is closely associated with inflammatory bowel disease. However, the effects and underlying mechanisms of maternal (MHFD) on susceptibility offspring to colitis in adulthood lacks confirmation. Methods: C57BL/6 pregnant mice were given (60 E% fat, MHFD group) control (10 (MCD) during gestation lactation respectively. After weaning, intestinal development, mucosal barrier function, microbiota inflammation 3 week-old assessed. All then...
Abstract BACKGROUND Photosynthetic pigments perform critical physiological functions in tea plants. Their content is an essential indicator of photosynthetic efficiency and nutritional status. The present study aimed to predict chlorophyll a (Chl a), b b), total (total Chl), carotenoid (Car) leaves under different levels nitrogen treatment using hyperspectral imaging (HSI) combination with variable selection algorithms. RESULTS A 150 samples were collected scanned the HSI system. mean...
Abstract Purple coneflower ( Echinacea purpurea (L.) Moench) is a popular native North American herbal plant. Its major bioactive compound, chicoric acid, reported to have various potential physiological functions, but little known about its biosynthesis. Here, taking an activity-guided approach, we identify two cytosolic BAHD acyltransferases that form intermediates, caftaric acid and chlorogenic acid. Surprisingly, unique serine carboxypeptidase-like acyltransferase uses as acyl donor...
Background Nonalcoholic fatty liver disease (NAFLD) is considered to be associated with diet and gut dysbiosis. Excessive sucralose can induce dysbiosis negatively affect host health. Maternal shapes the microbial communities of neonate this effect continues in later life. We aimed investigate effects maternal (MS) intake on susceptibility offspring hepatic steatosis adulthood.Methods C57BL/6 pregnant mice were randomized into MS group (MS during gestation lactation) control (MC) (MC diet)....
High-affinity CD4 T cells produce IL-21 to help CD8 differentiate into tissue-resident memory in the brain.
Early life events can lead to multiple diseases in adulthood. Previous studies suggested that polysorbate 80 (P80) as a widely used emulsifier pharmaceutical formulations and food industries could impair the intestinal barrier. However, whether maternal P80 (MP80) exposure affect long-term health of offspring remains unknown. In this study, we found intake retard development, disrupt barrier, cause low-grade inflammation 3-week-old offspring. 16S rRNA sequencing correlation analysis revealed
Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) infection mice mouse polyomavirus (MuPyV), we have shown that CD8 establish a PD-1hi, tissue-resident memory population in brains (bTRM) low-level persistent infection. In MuPyV encephalitis, PD-L1 was expessed on infiltrating myeloid cells, microglia and astrocytes, but not oligodendrocytes....
Inflammaging refers to chronic, low‐grade inflammation during aging, which contributes the pathogenesis of age‐related diseases. Studies have shown that probiotic intervention in aging stage could delay aging‐related disorders. However, whether application probiotics early life antiaging effects on offspring was unknown. Here, we investigated Lactobacillus rhamnosus GG ( LGG ) colonization inflammaging offspring. Pregnant mice with same conception time were given live bacteria (LC group) or...
The prevalence of inflammatory bowel disease (IBD) is increasing worldwide and correlates with dysregulated immune response because gut microbiota dysbiosis. Some adverse early life events influence the establishment act as risk factors for IBD. Prenatal maternal stress (PNMS) induces dysbiosis perturbs neuroimmune network offspring. In this study, we aimed to investigate whether PNMS increases susceptibility offspring colitis in adulthood. related index was assessed during weaning period We...
Maternal high fat diet (MHFD) increased colitis susceptibility in adulthood. However, the mechanism remains unclear. We sought to explore whether novel gut immune receptor leucine-rich repeat C19 (LRRC19) contributed impaired mucus barrier of offspring exposed MHFD via response and microbiota. The results showed that significantly intestinal offspring, up-regulated expression LRRC19. Lrrc19 deletion alleviated disruption. Mechanistically, metagenome sequencing revealed MHFD-induced...
The super-enhancer, a cluster of enhancers with strong transcriptional activity, has become one the most interesting topics in recent years. This study aimed to investigate pathogenic super-enhancer-driven genes IBD and screen therapeutic drugs based on results. In this study, through analysis differentially expressed colitis patients from GEO database super-enhancer-associated database, we found that super-enhancer PCK1 EFNA1 were simultaneously regulated by transcription factor CEBPB two...
The current method for processing bud yellow tea usually results in astringent taste that is not sufficiently yellowing. Therefore, two factors the production phase affect quality were studied: number of times leaves undergo yellowing process and predrying to reduce their water content before a second process. We then evaluated colour nonvolatile compounds produced tea. Results revealed gallated catechins polyphenol–amino acid ratio decreased significantly, changed from green after...
SUMMARY Chicoric acid is the major active ingredient of world‐popular medicinal plant purple coneflower ( Echinacea purpurea (L.) Menoch). It recognized as quality index commercial hot‐selling products. While biosynthetic pathway chicoric in has been elucidated recently, its regulatory network remains elusive. Through co‐expression and phylogenetic analysis, we found EpMYB2, a typical R2R3‐type MYB transcription factor (TF) responsive to methyl jasmonate (MeJA) simulation, positive regulator...
A comprehensive understanding of JCPyV-induced PML pathogenesis is needed to define determinants that predispose patients PML, a goal whose urgency heightened by the lack anti-JCPyV agents. handicap achieving this tractable animal model study pathogenesis. Using intracerebral inoculation with MuPyV, we found MuPyV encephalitis in wild-type mice causes an encephalopathy, which markedly exacerbated deficient STAT1, molecule involved transducing signals from type I, II, and III IFN receptors....
High pliability and promiscuity are observed widely exist in plant specialized metabolism, especially the hydroxycinnamic acid metabolism. Here, we identified an addition BAHD acyltransferase (EpHMT) that catalyzes phaselic biosynthesis found substrate promiscuities of SCPL acyltransferases responsible for diversity derivatives purple coneflower.Hydroxycinnamic (HADs) such as chicoric main active ingredients coneflower (Echinacea purpurea (L.) Moench). Recently, catalyzed by both serine...
JCPyV polyomavirus, a member of the human virome, causes progressive multifocal leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations major viral capsid protein, VP1, are common from PML patients (JCPyV-PML) but whether they confer neurovirulence or escape virus-neutralizing antibody (nAb) vivo is unknown. A mouse polyomavirus (MuPyV) with sequence-equivalent JCPyV-PML VP1 mutation replicated poorly kidney,...
Research has shown that maternal sucralose (MS) exposure alters the gut microbiota of offspring at weaning and predisposes to developing obesity, non-alcoholic fatty liver disease metabolic syndrome later in life.
Polyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there no currently approved antivirals treating polyomavirus infection. Brincidofovir (BCV) is an antiviral treatment of poxvirus infections and has shown activity against other double-stranded viruses. In this study, we tested efficacy BCV infection