A5101676889- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Esophageal and GI Pathology
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Glycosylation and Glycoproteins Research
- Gastrointestinal motility and disorders
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Luminescence and Fluorescent Materials
- Lysosomal Storage Disorders Research
- Advanced MRI Techniques and Applications
- Redox biology and oxidative stress
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Cancer Mechanisms and Therapy
- Ginseng Biological Effects and Applications
Sichuan Cancer Hospital
2025
University of Electronic Science and Technology of China
2025
Tianjin Medical University
2014-2025
Tianjin Nankai Hospital
2025
Chinese University of Hong Kong
2024
Tianjin Medical University General Hospital
2014-2024
Zhejiang University
2024
Sir Run Run Shaw Hospital
2024
Tianjin Infectious Diseases Hospital
2021
Shandong Normal University
2018
BackgroundAccumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed investigate the crucial role imbalanced microbiota on progression intestinal adenoma.MethodsThe Apcmin/+ mice gavage with phosphate-buffered saline (PBS), feces healthy controls or patients after antibiotic cocktails. The tissues were isolated for histopathology, western blotting, RNA-seq. short-chain fatty acids (SCFAs) analysed by...
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and lethal cancer. The role of autophagy in pathobiology PDAC intricate, with opposing functions manifested different cellular contexts. MIR506 as a tumor suppressor many cancer types through regulation multiple pathways. In this study, we hypothesized that exerted suppression function by inducing autophagy-related cell death. Our results provided evidence downregulation expression was associated disease progression human PDAC....
α-Amylase plays a key role in the physiological cycle of human body; its function is constantly explored and used as an important indicator some related diseases like acute pancreatitis, organophosphorus pesticide poisoning, anxiety or depression. However, currently, including assay kit, existing methods suffer from low sensitivity time consumption are indirect assays that require aid tool enzyme inhibitor competitive substrates; hence, they not suitable for activity nondestructive sensing...
Alpha-fetoprotein (AFP) is overexpressed in hepatocellular carcinoma (HCC) and could serve as a tumor-associated antigen (TAA) potential target for adoptive immunotherapy. However, low frequency severe functional impairment of AFP-specific T cells vivo hamper infusion. TAA-specific cell receptor (TCR) gene transfer be an efficient reliable alternation to generate cytotoxic lymphocytes (CTLs). Autologous dendritic (DC) pulsed with AFP158-166 peptides were used stimulate CTLs. TCR α/β chain...
The prevalence of inflammatory bowel disease (IBD) is increasing worldwide and correlates with dysregulated immune response because gut microbiota dysbiosis. Some adverse early life events influence the establishment act as risk factors for IBD. Prenatal maternal stress (PNMS) induces dysbiosis perturbs neuroimmune network offspring. In this study, we aimed to investigate whether PNMS increases susceptibility offspring colitis in adulthood. related index was assessed during weaning period We...
Colorectal cancer (CRC) is one of the leading causes cancer‑associated mortality worldwide and currently ranks third in USA terms prevalence. Transgelin‑2 (TAGLN2) was previously reported to serve as a tumor promoter various types cancer. The present study aimed investigate role TAGLN2 progression CRC determine potential underlying mechanism. expression level cells (HCT116, SNU‑C1, LoVo SW480) were first detected by reverse transcription quantitative PCR western blotting. Following knockdown...
Background There was much hard work to study the trastuzumab resistance in HER2-positive gastric cancer (GC), but information which would reveal this abstruse mechanism is little. In study, we aimed investigate roles of tumor cell-derived CCL2 on and overcome by treatment with anti-CD40-scFv-linked anti-HER2 (CD40 ×HER2) bispecific antibody (bsAb). Methods We measured levels expression GC tissues, revealed biological functions tumor-associated macrophages (TAMs) resistance. Then, developed...
Although laparoscopic distal gastrectomy has been widely used for gastric cancer, the best functional reconstruction type not yet established. Based on previous experience, we propose a modified uncut Roux-en-Y anastomosis. This study aimed to compare outcomes of different intracorporeal anastomoses after gastrectomy.From April 2015 August 2020, data 215 patients who underwent was collected. The were divided into 4 groups according digestive tract method, Billroth-I, Billroth-II, Roux-en-Y,...
Abstract Background Esophagojejunostomy after minimally invasive total gastrectomy (MITG) for gastric cancer (GC) is technically challenging. Failure of the esophagojejunal anastomosis can lead to significant morbidity, leading short- and long-term quality life (QoL) impairment or mortality. The optimal reconstruction method following MITG remains controversial. We evaluated outcomes esophagojejunostomy laparoscopic robotic gastrectomies. Methods retrospectively reviewed patients between...
Abstract Targeting the pivotal pathological processes of acute kidney injury (AKI) and parallelly monitoring treatment process has emerged as an intriguing strategy for timely tailored AKI, especially in phase. Unfortunately, current clinical approaches are restricted to supportive care, which shows limited efficiency. Herein, a multiantioxidant‐cooperative polydopamine‐based nanotheranostic platform (mc‐PDATP) is reported achieve imaging‐assisted time‐sensitive therapy AKI. Benefiting from...
Cisplatin (DDP) resistance in gastric cancer (GC) is likely to come from stem cells (GCSC). It a new idea study the mechanism of DDP-resistance GCSC miRNA.
// Longhao Sun 1 , Hao Guo Ruoyu Jiang Li Lu Tong Liu Zhixiang Zhang and Xianghui He Department of General Surgery, Tianjin Medical University Hospital, Tianjin, China Correspondence to: He, email: Keywords : artificial antigen-presenting cells, alpha-fetoprotein, interleukin-15, cytotoxic T lymphocytes, adoptive immunotherapy, Immunology Microbiology Section, Immune response, Immunity Received November 30, 2015 Accepted March 14, 2016 Published 19, Abstract Professional cells (APCs) are...
In eukaryotic cells, the endoplasmic reticulum (ER) forms a continuous network of tubules and sheets. ER membranes are inter-connected by class dynamin-like GTPases termed atlastins (ATLs). Deletion or mutation ATLs results in long unbranched cells. Mutations ATL1 humans have been linked to neurodegenerative disease hereditary spastic paraplegia. The basis ATL-mediated membrane fusion has studied extensively, but specific functions ATL remain unclear. this review, we summarize ER-related...
To explore the changes in time-signal intensity curve(TIC) type and semi-quantitative parameters of dynamic contrast-enhanced(DCE)imaging relation to variations contrast agent(CA) dosage Walker 256 murine breast tumor model, determine appropriate for evaluation ofneoadjuvantchemotherapy(NAC)response.Walker models were established 21 rats, which randomly divided into three groups of7rats each. Routine scanning DCE-magnetic resonance imaging (MRI) rats performed using a 7T MR scanner. The...