A5101765221- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Acute Kidney Injury Research
- Treatment of Major Depression
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
- Tissue Engineering and Regenerative Medicine
- Pancreatitis Pathology and Treatment
- Tryptophan and brain disorders
- Medical Research and Treatments
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Induction Heating and Inverter Technology
- Platelet Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- NF-κB Signaling Pathways
- DNA Repair Mechanisms
Qingdao Eighth People's Hospital
2024
Tianjin Medical University General Hospital
2014-2023
Sir Run Run Shaw Hospital
2023
Zhejiang University
2004-2023
Tianjin Medical University
2023
Tianjin Chest Hospital
2023
Tianjin University
2023
First Affiliated Hospital Zhejiang University
2018
Third Hospital of Hebei Medical University
2017
Hebei Medical University
2017
Colorectal cancer (CRC) is one of the leading causes cancer‑associated mortality worldwide and currently ranks third in USA terms prevalence. Transgelin‑2 (TAGLN2) was previously reported to serve as a tumor promoter various types cancer. The present study aimed investigate role TAGLN2 progression CRC determine potential underlying mechanism. expression level cells (HCT116, SNU‑C1, LoVo SW480) were first detected by reverse transcription quantitative PCR western blotting. Following knockdown...
Although laparoscopic distal gastrectomy has been widely used for gastric cancer, the best functional reconstruction type not yet established. Based on previous experience, we propose a modified uncut Roux-en-Y anastomosis. This study aimed to compare outcomes of different intracorporeal anastomoses after gastrectomy.From April 2015 August 2020, data 215 patients who underwent was collected. The were divided into 4 groups according digestive tract method, Billroth-I, Billroth-II, Roux-en-Y,...
Excision repair cross-complementation (ERCC) enzymes are key members of the nucleotide excision pathway. Dysregulation ERCC family has been shown to be involved in chemoresistance several malignancies. However, function ERCC6 regulating chemo response not evaluated colorectal cancer (CRC). We stably knocked down expression using short hairpin RNA (shRNA) HCT116 and DLD1 human colon cell lines, followed by chemosensitivity assay. In vivo chemosensitizing effects were examined xenograft...
Abstract Background Esophagojejunostomy after minimally invasive total gastrectomy (MITG) for gastric cancer (GC) is technically challenging. Failure of the esophagojejunal anastomosis can lead to significant morbidity, leading short- and long-term quality life (QoL) impairment or mortality. The optimal reconstruction method following MITG remains controversial. We evaluated outcomes esophagojejunostomy laparoscopic robotic gastrectomies. Methods retrospectively reviewed patients between...
Indoleamine 2, 3-dioxygenase (IDO)-mediated regulation of tryptophan metabolism plays an important role in immune tolerance transplantation, but it has not been elucidated which mechanism specifically induces the occurrence tolerance. Our study revealed that IDO exerts immunosuppressive effects through two pathways mouse heart 'tryptophan depletion' and metabolite accumulation'. The synergism between IDO+ DC TC (tryptophan catabolic products) stronger inhibitory on T lymphocyte proliferation...
Background and Aim: Lymph node involvement is the strongest prognostic factor for patients with gastric cancer; node-negative cancer present better survival. However, some develop recurrent cancer. The aim of this study was to review clinicopathological characteristics factors prognosis in who underwent curative resection. Methods: Between January 2004 December 2015, 302 gastrectomy our hospital were retrospectively analyzed. Results: 1-, 3-, 5-year overall survival rates 80.0%, 69.0%,...
The aim of the present study was to investigate expression levels miR-146a and miR-155 in a cardiac xenograft model treated with immunosuppressant FK506, construct lentiviral vectors further roles xenotransplantation. Expression were examined by quantitative polymerase chain reaction analysis protein RelA, which is member nuclear factor-κB family, western blot analysis. Pre-miR-146a pre-miR-155 fragments designed synthesized according MiRBase cloned into plasmid pCDH1-MCS1-EF1-copGFP....
Abstract Gastric cancer is a disease with high heterogeneity, and this heterogeneity may result in an uneven distribution of subclones varied genetic properties at locations (spatial heterogeneity) or temporal changes subclonal composition (temporal heterogeneity). We present the case 69-year-old woman metastatic gastric who presented for axillary lymph node enlargement underwent lymphadenectomy. Pathological evidence showed human epidermal growth factor receptor 2 (HER2)(3+). Abdominal...
Aim: The majority of available data on the clinical efficacy sunitinib in patients with imatinib-resistant or -intolerant gastrointestinal stromal tumours (GISTs) are from studies western populations. We investigated outcomes imatinib dose escalation versus first-line imatinib-failure Asian GIST to further guide treatment.Methods: Patients received and a shift (Group A) direct B). objective tumour response was assessed according Choi’s criteria. Progression-free survival (PFS) overall (OS)...
A primary duodenal malignant tumor (PDMT) is an extremely uncommon malignancy that originates from a gastrointestinal tract tumor. Currently, there no unified, effective surgical treatment for PDMTs. In this retrospective study, we sought to analyze and evaluate the procedure PDMTs including pancreaticoduodenectomy (PD) limited resection (LR), expect inform management of PDMT.We retrospectively reviewed patients with PDMT who underwent PD LR in General Surgery Department Tianjin Medical...
Abstract Eltrombopag, a nonpeptide thrombopoietin receptor agonist, is primarily used for treating immune thrombocytopenic purpura. The aim of this study was to investigate the pharmacokinetic profile and food‐drug interaction test reference eltrombopag olamine tablets among healthy Chinese volunteers. An open, randomized, single‐dose, 2‐period crossover design employed, involving fasting fed conditions with 10‐day washout period. Ninety‐six volunteers received single oral dose 25 mg 2...
Abstract The aim of this study was to investigate the pharmacokinetics, bioequivalence, and safety generic trazodone hydrochloride sustained‐release tablet its reference listed product in healthy Chinese subjects. An open, randomized, single‐dose, 2‐period crossover involved under fasting fed conditions, with a 7‐day washout period. A single oral dose 150 mg 2 tablets administered 84 volunteers, 36 group 48 consuming high‐fat diet, respectively. plasma concentrations were analyzed using...
Pouchitis is the most common complication following restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). Fecal calprotectin (FC) a noninvasive indicator of intestinal inflammatory status. This study was conducted to evaluate clinical value FC concentration diagnosis risk assessment pouchitis.This retrospective involved patients who underwent IPAA UC at Tianjin Medical University General Hospital from January 2015 2019. The were categorized into...
Severe acute pancreatitis (SAP) can affect intestinal barrier with a high mortality. To date, effective therapies for SAP are still in urgently need. The purpose of this study was to investigate the role anthranilic acid active synthetic derivative, N-(3',4'-dimethoxycinnamonyl) (3,4-DAA), dysfunction SAP. In study, mice model induced by caerulein combined lipopolysaccharide (LPS). were pretreated 3,4-DAA orally. Histological structures pancreatic and tissues observed via hematoxylin-eosin...