A5100392687- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Insect and Arachnid Ecology and Behavior
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Animal Behavior and Reproduction
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Graphene research and applications
- Biochemical effects in animals
- Advanced Sensor and Energy Harvesting Materials
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Insect and Pesticide Research
- Neuroscience and Neural Engineering
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Ion-surface interactions and analysis
- Genetics, Aging, and Longevity in Model Organisms
- Anaerobic Digestion and Biogas Production
- Ion Transport and Channel Regulation
Nanjing University of Science and Technology
2024-2025
Chinese Academy of Sciences
2002-2023
Center for Excellence in Brain Science and Intelligence Technology
2018-2023
Beijing Normal University
2021-2022
Rutgers New Jersey Medical School
2018-2022
Rutgers, The State University of New Jersey
2006-2022
Beijing Normal University - Hong Kong Baptist University United International College
2022
Institute of Automation
2021
Tianjin Medical University General Hospital
2020
University of Miami
2019
Detection of specific female pheromones stimulates courtship behavior in Drosophila melanogaster males, but the chemosensory molecules, cells, and mechanisms involved remain poorly understood. Here we show that ppk25, a DEG/ENaC ion channel subunit required for normal male response to females, is expressed at highest levels single sexually dimorphic gustatory neuron most taste hairs on legs wings, not neurons detect courtship-inhibiting or food. Synaptic inactivation ppk25-expressing...
Abstract Bioelectronics is an exciting field that bridges the gap between physiological activities and external electronic devices, striving for high resolution, conformability, scalability, ease of integration. One crucial component in bioelectronics bioelectrodes, designed to convert neural activity into signals or vice versa. Previously reported bioelectrodes have struggled meet several essential requirements simultaneously: high‐fidelity signal transduction, charge injection capability,...
As in many species, gustatory pheromones regulate the mating behavior of Drosophila. Recently, several ppk genes, encoding ion channel subunits DEG/ENaC family, have been implicated this process, leading to identification neurons that detect specific pheromones. In a subset taste hairs on legs Drosophila, there are two ppk23-expressing, pheromone-sensing with complementary response profiles; one neuron detects female stimulate male courtship, other inhibit male-male courtship. contrast...
With flavone as a structural template, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies and ab initio calculations were performed on series of flavonoids. A reasonable pharmacophore model was built through CoMFA, CoMSIA, HQSAR analyses electrostatic potential calculations. plausible binding mode for flavonoids with GABA(A) receptors rationalized. On the basis commonly recognized site, specific S1 S2 subsites relating to substituent positions proposed. The...
Trimeric sodium channels of the DEG/ENaC family have important roles in neurons, but specific functions different subunits present heteromeric are poorly understood. We previously reported that Drosophila subunit Ppk25 is essential a small subset gustatory neurons for activation male courtship behavior, likely through detection female pheromones. Here we show that, like mutations ppk25 , another gene, nope specifically impair females. regulatory sequences drive reporter gene expression...
Portulaca oleracea L. is a traditional Chinese medicine, which has been used as adjuvant therapy for inflammatory bowel disease (IBD). However, the mechanism of its activity in IBD still remains unclear. Since previous studies have documented anti-inflammatory effect peroxisome proliferator activated receptors- γ (PPAR- ), regulation PPAR- inflammation was examined current study. Ulcerative colitis (UC) generated by 5% dextran sulfate sodium (DSS) mice and four groups were established normal...
Abstract Bioelectrodes function as a critical interface for signal transduction between living organisms and electronics. Conducting polymers (CPs), particularly poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate), are among the most promising materials bioelectrodes, due to their electrical performance, high compactness, ease of processing, but often suffer from degradation or de‐doping even in some common environments (e.g., stimulation, chemicals, temperatures). This instability...
In Drosophila , pheromones play a crucial role in regulating courtship behaviors. males, female aphrodisiac promote male‐female courtship, and male antiaphrodisiac inhibit male‐male courtship. Previous studies have reported that receptor proteins belonging to the pickpocket (ppk) family, ionotropic family gustatory are required for pheromone detection normal However, none of them has been shown be sufficient sensing after ectopic expression originally unresponsive cells. “M” cells activated...
Autophagy is a major means for the elimination of protein inclusions in neurons neurodegenerative diseases such as Parkinson’s disease (PD). Yet, mechanism autophagy other brain cell type, glia, less well characterized and remains largely unknown. Here, we present evidence that PD risk factor, Cyclin-G-associated kinase (GAK)/ Drosophila homolog Auxilin (dAux), component glial autophagy. The lack GAK/dAux increases autophagosome number size adult fly glia mouse microglia, generally...
Abstract Purple non‐sulfur (PNS) bacteria produce hydrogen by photofermentation of organic acids in wastewater. However, NH wastewater may inhibit synthesis repressing the expression and activity nitrogenase, enzyme catalyzing production PNS bacteria. In this study, Rhodobacter sphaeroides 6016 glnA gene encoding glutamine synthetase (GS) was knocked out homologous recombination, effects on nitrogenase were examined. Using 3 mM as nitrogen source, (1,245–1,588 mL hydrogen/L culture) detected...
Previous studies have demonstrated that the trafficking defects of Nav1.1/Nav1.2 are involved in dementia pathophysiology. However, detailed mechanisms not fully understood. Moreover, whether impaired miRNAs regulation linked to is a key player sodium channel disturbance remains unclear. The cognitive impairment induced by chronic cerebral ischemia through brain hypoperfusion (CBH) likely reason precede dementia. Therefore, our goal present study was examine role microRNA-9 (miR-9)...
Abstract Drosophila amyloid precursor‐like protein (APPL) is expressed extensively in the nervous system soon after neuronal differentiation. By utilizing different transgenic flies, we studied physiological function of two APPL forms, membrane‐bound form (mAPPL) and secreted (sAPPL), neural development. We found that neither deletion nor overexpression altered gross structure mushroom bodies adult brain. No changes were detected cell types their relative ration embryo‐derived cultures from...
In the present study, BmK αIV, a novel modulator of sodium channels, was cloned from venomous glands Chinese scorpion (Buthus martensi Karsch) and expressed successfully in Escherichia coli. The αIV gene is composed two exons separated by 503 bp intron. mature polypeptide contains 66 amino acids. has potent toxicity mice cockroaches. Surface-plasmon-resonance analysis found that could bind to both rat cerebrocortical synaptosomes cockroach neuronal membranes, shared similar binding sites on...
On 12 May 2008, the 8.0-magnitude Wenchuan earthquake occurred in Sichuan Province, China, triggering thousands of landslides, debris flows, and barrier lakes, leading to a substantial loss life damage local environment infrastructure. This study aimed monitor status geologic hazards vegetation recovery post-earthquake disaster area using high-resolution aerial photography from 2008 2011, acquired Center for Earth Observation Digital (CEODE), Chinese Academy Sciences. The distribution range...
Indoleamine 2, 3-dioxygenase (IDO)-mediated regulation of tryptophan metabolism plays an important role in immune tolerance transplantation, but it has not been elucidated which mechanism specifically induces the occurrence tolerance. Our study revealed that IDO exerts immunosuppressive effects through two pathways mouse heart 'tryptophan depletion' and metabolite accumulation'. The synergism between IDO+ DC TC (tryptophan catabolic products) stronger inhibitory on T lymphocyte proliferation...
Long-term tobacco use causes nicotine dependence via the regulation of a wide range genes and is accompanied by various health problems. Studies in mammalian systems have revealed some key factors involved effects nicotine, including nicotinic acetylcholine receptors (nAChRs), dopamine other neurotransmitters. Nevertheless, signaling pathways that link nicotine-induced molecular behavioral modifications remain elusive. Utilizing chronic administration paradigm, we found adult male fruit...
In Drosophila melanogaster, olfactory projection neurons (PNs) convey odor information from the antenna lobe to higher brain regions. Recent transcriptomic studies reveal a large diversity of transcription factors, cell-surface molecules, neurotransmitter-coding, and neuropeptide-coding genes in PNs; however, their structural remains unknown. Herein, we achieved volumetric reconstruction 89 PN boutons under Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) quantitatively analyzed...
Active enkephalin and related peptide hormones or neurotransmitters are generated by proteolytic processing of inactive prohormone precursors. Little is known about the relative accessibilities cleavage sites conformations subdomains that undergo processing. Therefore, this study investigated conformational features proenkephalin (PE) rapid hydrogen-deuterium exchange mass spectrometry (DXMS). DXMS analyzes rates hydrogen polypeptide backbone PE with deuterium from D(2) O (heavy water)...
Abstract The growing use of N ‐acetylaspartate as an indicator neuronal viability has fostered interest in the biological function(s) this unusual amino acid derivative. In considering various physiological roles that have been proposed for relatively abundant molecule one is obliged to take into account its metabolic compartmentalization, according which synthesis and storage occur neuron hydrolytic cleavage oligodendrocyte. latter reaction, catalyzed by aspartoacylase (ASPA), produces...
Monoaminergic neurotransmitter 5-hydroxytryptamine (5-HT), also known as serotonin, plays important roles in modulating the function of olfactory system. However, thus far, knowledge about 5-HT and its receptors receptor neurons (ORNs) their physiological role have not been fully characterized. In present study, reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed presence 5-HT1A 5-HT1B subtypes mouse epithelium at mRNA level. With subtype selective antibodies standard...