A5100404403- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Tryptophan and brain disorders
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Bone Tumor Diagnosis and Treatments
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Treatment of Major Depression
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Colorectal and Anal Carcinomas
- Bipolar Disorder and Treatment
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
Tianjin Medical University General Hospital
2013-2024
Tianjin Medical University
2024
Guangzhou University of Chinese Medicine
2023
To investigate the effects of excessive tryptophan intake on body and metabolism-related aryl hydrocarbon receptor (AhR) pathway in healthy rats chronic kidney disease rats, to study adverse excess tryptophan.In Part I Experiment, were fed with diet containing 0.6, 1.2 1.8% for 12 weeks. After intervention, blood tissues collected. Serum creatinine urea nitrogen detected. Hematoxylin-eosin (H&E) staining was used observe renal pathological changes. Enzyme-linked immunosorbent assay detect...
Although laparoscopic distal gastrectomy has been widely used for gastric cancer, the best functional reconstruction type not yet established. Based on previous experience, we propose a modified uncut Roux-en-Y anastomosis. This study aimed to compare outcomes of different intracorporeal anastomoses after gastrectomy.From April 2015 August 2020, data 215 patients who underwent was collected. The were divided into 4 groups according digestive tract method, Billroth-I, Billroth-II, Roux-en-Y,...
Abstract Background: Optimal adjuvant chemotherapy after laparoscopic surgery in gastric cancer (GC) patients is still undefined. We aimed to evaluate the efficacy of S‐1 plus oxaliplatin (SOX) and capecitabine (CAPOX) with GC gastrectomy. Methods: A non‐inferiority randomized controlled clinical trial was performed China. Patients advanced who underwent D2 gastrectomy were randomly assigned receive SOX CAPOX regimens. Results: In total, 191 screened between May 2018 June 2019, 140 (73.3%)...
Abstract Background Esophagojejunostomy after minimally invasive total gastrectomy (MITG) for gastric cancer (GC) is technically challenging. Failure of the esophagojejunal anastomosis can lead to significant morbidity, leading short- and long-term quality life (QoL) impairment or mortality. The optimal reconstruction method following MITG remains controversial. We evaluated outcomes esophagojejunostomy laparoscopic robotic gastrectomies. Methods retrospectively reviewed patients between...
Indoleamine 2, 3-dioxygenase (IDO)-mediated regulation of tryptophan metabolism plays an important role in immune tolerance transplantation, but it has not been elucidated which mechanism specifically induces the occurrence tolerance. Our study revealed that IDO exerts immunosuppressive effects through two pathways mouse heart 'tryptophan depletion' and metabolite accumulation'. The synergism between IDO+ DC TC (tryptophan catabolic products) stronger inhibitory on T lymphocyte proliferation...
Cisplatin (DDP) resistance in gastric cancer (GC) is likely to come from stem cells (GCSC). It a new idea study the mechanism of DDP-resistance GCSC miRNA.
Abstract Background Endometrial regenerative cells (ERCs) play an important role in attenuation of acute allograft rejection, while their effects are limited. IL-37, a newly discovered immunoregulatory cytokine the IL-1 family, can regulate both innate and adaptive immunity. Whether IL-37 overexpression enhance therapeutic ERCs inhibition cardiac rejection remains unknown will be explored this study. Methods C57BL/6 mice recipients receiving BALB/c mouse heterotopic heart allografts were...
Xenograft rejection poses the largest obstacle to successful xenotransplantation. Recent studies have demonstrated that miRNAs play essential roles in embryogenesis, cell proliferation, and pathogenesis of human diseases. However, role miRNA regulating xenograft is relatively unknown. This study was undertaken analyze profile intragraft expression a heterotopic mouse-to-rat cardiac xenotransplantation model. Using microarray analysis, total 579 were detected grafts following transplantation....
Ferroptosis, a novel form of regulating cell death, is related to various cancers. However, the role ferroptosis-related genes (FRGs) on occurrence and development colon cancer (CC) needs be further elucidated.CC transcriptomic clinical data were downloaded from TCGA GEO databases. The FRGs obtained FerrDb database. consensus clustering was performed identify best clusters. Then, entire cohort randomly divided into training testing cohorts. Univariate Cox, LASSO regression multivariate Cox...
Mesenchymal stem cells are easy to obtain and expand, with characteristics of low immunogenicity strong tissue repair capacity. In this study, our aim was investigate the role mesenchymal in chronic immune rejection heterotopic small intestine transplant rats.After successfully constructing a rat model transplant, we infused into animal recipients. We observed cell location recipients, recipient survival, pathology changes, expression CD68, transforming growth factor β1, platelet-derived C...
Objective To investigate the effect of high expression functional IDO trom donor DCs on transplantation rejection in mice heterotopic cardiac transplantation.Method Adenovirus vector containing gene was used to infect (C57BL/6) obtain IDO+ DCs.Mouse models were established (C57BL/6-BALB/c) and following groups set up:control group,DCs injection group group.Survival time heart all observed.Meanwhile,donor hearts harvested at 7 th day post-transplantation for different examinations,including...
<title>Abstract</title> <bold>Background</bold> Tumor differentiation grade has been shown to be an independent prognostic factor in gastric cancer (GC). Here,we report a novel tumor grade-related genes signature predict prognosis and provide new biomarkers GC. <bold>Methods</bold> ScRNA-seq profiles of GC were analyzed by seurat package. Core modules key related identified through weighted gene co-expression network analysis (WGCNA) from The Cancer Genome Atlas (TCGA) database. A associated...
Abstract Background Primary malignant tumors of the small bowel (PMTSB) are relatively uncommon in gastrointestinal tumors. It is difficult to make an early diagnosis due atypical primary symptoms, special anatomical position and lack effective diagnostic methods. Objective To improve level PMTSB so as speculate pathological types get better prognoses for patients. Method Clinicopathologic follow-up data about 104 surgically treated patients with (65 males 39 females) at median age 58.1...