A5032252692- Reproductive System and Pregnancy
- Transplantation: Methods and Outcomes
- Extracellular vesicles in disease
- Endometriosis Research and Treatment
- Adenosine and Purinergic Signaling
- Ferroptosis and cancer prognosis
- Renal Transplantation Outcomes and Treatments
- Mesenchymal stem cell research
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Organ Transplantation Techniques and Outcomes
- Pregnancy and Medication Impact
- Immune cells in cancer
- Inflammatory Bowel Disease
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Organ and Tissue Transplantation Research
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Microscopic Colitis
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
Tianjin Medical University General Hospital
2021-2025
Tianjin Medical University
2021-2024
The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited...
Renal ischemia reperfusion (I/R) injury is a major contributor to graft dysfunction and inflammation leading loss. The deregulation of purinergic signaling has been implicated in the pathogenesis renal I/R injury. CD73 generation adenosine during purine metabolism protect against A mesenchymal-like endometrial regenerative cell (ERC) demonstrated significant therapeutic effect on phenotypic marker human exosomes (ERC-Exo). However, its immunosuppressive function regulating largely neglected....
Solid organ transplantation remains a life-saving therapeutic option for patients with end-stage dysfunction. Acute cellular rejection (ACR), dominated by dendritic cells (DCs) and CD4
Endometrial regenerative cells (ERCs) have been identified to ameliorate colitis in mice; however, whether exosomes derived from ERCs (ERC-exos) own similar effects on remains unclear. Ferroptosis, an iron-dependent cell programmed death form, has reported promote inflammation UC. Thus, this study, ERC-exos can treat and regulate intestine ferroptosis will be explored. In iron, malondialdehyde (MDA) production, glutathione (GSH) synthesis, acyl-CoA synthetase long-chain family member (ACSL)...
Abstract The majority of patients with advanced colorectal cancer have chemoresistance to oxaliplatin, and studies on oxaliplatin resistance are limited. Our research showed that RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) caused ferroptosis in tumor cells, leading resistance. We employed bioinformatics evaluate publically accessible data sets discovered RBMS1 was significantly upregulated oxaliplatin‐resistant tandem suppression. In vivo vitro revealed inhibiting...
Exosomes derived from endometrial regenerative cells (ERC-Exos) can inherit the immunomodulatory function ERCs, however, whether ERC-Exos exhibit such effect on inflammatory bowel diseases with mucosal immune dysregulation has not been explored. Insulin-like growth factor-Ⅱ (IGF2) is considered to possess potential induce an anti-inflammatory phenotype in cells. In this study, contribution of IGF2 mediating protective efficacy colitis was investigated.
Traditional interventions can play a certain role in attenuating ulcerative colitis (UC), known as one type of inflammatory bowel diseases, but sometimes are not effective. Endometrial regenerative cells (ERCs) have been shown to exert immunosuppressive effects different models inflammation, and stem cell-derived conditioned media (CM) advantages over cell therapy terms easy access direct action. However, whether ERC-CM could alleviate remains unclear will be explored this study. Menstrual...
The prognostic value of m6A-related genes in hepatocellular carcinoma (HCC) and its correlation with the immune microenvironment still requires further investigation.Consensus clustering by m6A related was used to classify 374 patients HCC from Cancer Genome Atlas (TCGA) database. Then we performed least absolute shrinkage selection operator (LASSO) construct model. International Consortium (ICGC) Gene Expression Omnibus (GEO) datasets were verify evaluate ESTIMATE, CIBERSORTx, expression...
Abstract Background Endometrial regenerative cells (ERCs) play an important role in attenuation of acute allograft rejection, while their effects are limited. IL-37, a newly discovered immunoregulatory cytokine the IL-1 family, can regulate both innate and adaptive immunity. Whether IL-37 overexpression enhance therapeutic ERCs inhibition cardiac rejection remains unknown will be explored this study. Methods C57BL/6 mice recipients receiving BALB/c mouse heterotopic heart allografts were...
The disruption of intestinal barrier functions and the dysregulation mucosal immune responses, mediated by aberrant purinergic metabolism, are involved in pathogenesis inflammatory bowel diseases (IBD). A novel mesenchymal-like endometrial regenerative cells (ERCs) has demonstrated a significant therapeutic effect on colitis. As phenotypic marker ERCs, CD73 been largely neglected for its immunosuppressive function regulating metabolism. Here, we have investigated whether expression ERCs is...
Abstract Background As a kind of mesenchymal-like stromal cells, endometrial regenerative cells (ERCs) have been demonstrated effective in the treatment Concanavalin A (Con A)-induced hepatitis. However, therapeutic mechanism ERCs is not fully understood. Ecto-5`-nucleotidase (CD73), an enzyme that could convert immune-stimulative adenosine monophosphate (AMP) to immune-suppressive (ADO), was identified highly expressed on ERCs. The present study conducted investigate whether expression CD73...
Background Chronic rejection characterized by chronic allograft vasculopathy (CAV) remains a major obstacle to long-term graft survival. Due multiple complicated mechanisms involved, novel therapy for CAV exploration. Although mesenchymal stromal cells (MSCs) have been ubiquitously applied various refractory immune-related diseases, rare research makes thorough inquiry in CAV. Meanwhile, melatonin (MT), wide spectrum of immunomodulator, plays non-negligible role transplantation immunity....
Ulcerative colitis (UC) is a chronic intestinal inflammatory disease with complex etiology. Interleukin-35 (IL-35), as cytokine immunomodulatory function, has been shown to have therapeutic effects on UC, but its mechanism not yet clear. Therefore, we constructed Pichia pastoris stably expressing IL-35 which enables the cytokines reach diseased mucosa, and explored whether upregulation of T-cell protein tyrosine phosphatase (TCPTP) in macrophages involved mechanisms IL-35-mediated...
Immunotherapy has been considered as a promising cancer treatment for hepatocellular carcinoma (HCC). However, due to the particular immune environment of liver, identifying patients who could benefit from immunotherapy is critical in clinical practice.The pyroptosis gene expression database 54 candidates The Cancer Genome Atlas (TCGA) were collected discover prognostic-related genes. A novel model was established calculate risk score. Kaplan-Meier analysis and receiver operating...