A5100458627- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Metabolomics and Mass Spectrometry Studies
- Trace Elements in Health
- Liver Disease and Transplantation
- Sexual function and dysfunction studies
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Ginseng Biological Effects and Applications
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Preterm Birth and Chorioamnionitis
- Glaucoma and retinal disorders
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Heavy Metal Exposure and Toxicity
- Advanced Drug Delivery Systems
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Sirtuins and Resveratrol in Medicine
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Ningxia Medical University
2024
Ningxia Medical University General Hospital
2024
Tongji Hospital
2017-2024
Chengdu University of Traditional Chinese Medicine
2023-2024
Huazhong University of Science and Technology
2017-2024
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2024
West China Hospital of Sichuan University
2020-2024
Sichuan University
2020-2024
SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as potential therapeutic target in variety of neurodegenerative diseases, including Parkinson’s disease (PD). Our previous study demonstrates had neuroprotective effect on rotenone-induced PD cell model, however, the exact mechanism unknown. In this study, we investigated underlying mechanism. We established stable overexpression line using lentivirus...
Phytoestrogens are estrogen-like compounds of plant origin. The pharmacological activities phytoestrogens predominantly due to their antioxidant, anti-inflammatory and lipid-lowering properties, which mediated via the estrogen receptors (ERs): receptor alpha (ERα) beta (ERβ) possibly G protein-coupled 1 (GPER). Gypenoside XVII (GP-17) is a phytoestrogen that widely used prevent cardiovascular disease, including atherosclerosis, but mechanism underlying these therapeutic effects largely...
SGs as safe natural sweeteners, may yield significant improvement in glucose metabolism adult participants when compared with the control.
With growing restrictions on the use of antibiotics in animal feed, plant extracts are increasingly favored as natural feed additive sources. Glycyrrhiza polysaccharide (GP), known for its multifaceted biological benefits including growth promotion, immune enhancement, and antioxidative properties, has been focus recent studies. Yet, effects mechanisms GP broiler meat quality remain to be fully elucidated. This study aimed investigate growth, serum biochemistry, quality, gene expression...
Scope l ‐Theanine ( ‐Thea) is an amino acid which naturally present in tea leaves. It has been associated with possible health advantages, including obesity prevention, but the underlying molecular mechanisms have not elucidated. Methods and results A multiomics approach utilized to examine mechanism by ‐Thea exerts its antiobesity effects. This study reveals that administration significantly ameliorates high‐fat diet (HFD)‐induced rats improving body weight hyperlipidemia. mitigates...
Endometrial regenerative cells (ERCs) have been identified to ameliorate colitis in mice; however, whether exosomes derived from ERCs (ERC-exos) own similar effects on remains unclear. Ferroptosis, an iron-dependent cell programmed death form, has reported promote inflammation UC. Thus, this study, ERC-exos can treat and regulate intestine ferroptosis will be explored. In iron, malondialdehyde (MDA) production, glutathione (GSH) synthesis, acyl-CoA synthetase long-chain family member (ACSL)...
The impairment of blood-brain barrier (BBB) is one the key contributors to maternal inflammation induced brain damage in offspring. Our previous studies showed Fibrinogen-like protein 2 (FGL2) deficiency alleviated perinatal damage. However, its role BBB remains undefined.Lipopolysaccharide (LPS) was intraperitoneally injected dams at Embryonic day 17 establish model. FGL2 knockout mice and primary microvascular endothelial cells (BMECs) were used for in-vivo in-vitro experiments. integrity...
Glaucoma is a serious complication of glucocorticoid (GC) therapy arising through elevations in intraocular pressure (IOP). Dexamethasone (DEX) reported to contribute elevated IOP different effects on the trabecular meshwork but whether DEX contributes glaucoma development induction cellular senescence still unclear. We explored actions transformed human cells (HTMCs) using RNA-seq and conducted bioinformatic analyses determine affected pathways. Among 4,103 differentially expressed genes...
Non-alcoholic fatty liver (NAFL) has the potential to progress non-alcoholic steatohepatitis (NASH) or promote type 2 diabetes mellitus (T2DM). However, NASH and T2DM do not always develop coordinately. Additionally, there are no definite noninvasive methods for diagnosis currently. We established rat models of NAFL, NASH, NAFL + recapitulate different phenotypes associated with disease (NAFLD) its progression. Histologic features livers were scored according criteria by Nonalcoholic...
Abstract Objective to identify multimorbidity patterns among middle-aged and older adults in China examine how these are associated with incident disability recovery of independence. Methods data were from The Health Retirement Longitudinal Study. We included 14,613 persons aged ≥45 years. Latent class analysis (LCA) was conducted clinical meaningfulness. Multinomial logistic models used determine the adjusted association between Results we identified four patterns: ‘low morbidity’ (67.91%...
Statins were regarded as a main medication for managing hypercholesterolemia. Administration of statin therapy could reduce the incidence cardiovascular disease in individuals diagnosed with type 2 diabetes mellitus (DM), which was recognized by multipal clinical guidelines. But previous studies had conflicting results on whether long-term use statins benefit renal function diabetic patients.
Background. Exposure to fine particulate matter (PM2.5) is associated with the risk of developing metabolic-associated fatty liver disease (MAFLD). Melatonin main secreted product pineal gland and has been reported prevent hepatic lipid metabolism disorders. However, it remains uncertain whether melatonin could protect against PM2.5-induced MAFLD. Methods Results. The purpose our study was investigate mitigating effects on degeneration accelerated by PM2.5 in vivo vitro. Histopathological...
To investigate the effects of mesenchymal stem cell-conditioned medium (MSC-CM) on radiation-induced oxidative stress, survival and apoptosis in hippocampal neurons.The following groups were defined: Control, radiation treatment (RT), RT+MSC-CM, MSC-CM, RT + N-Acetylcysteine (RT+NAC), MSC-CM PI3 K inhibitor (LY294002). A cell Counting Kit-8 (CCK-8) was used to measure proliferation. Apoptosis examined by AnnexinV/PI flow cytometric analyses. Intracellular reactive oxygen species (ROS)...