A5007812706- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Drug-Induced Adverse Reactions
- Atrial Fibrillation Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Patient Safety and Medication Errors
- IL-33, ST2, and ILC Pathways
- Potassium and Related Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lipoproteins and Cardiovascular Health
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Diabetes Treatment and Management
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood disorders and treatments
- Cancer Immunotherapy and Biomarkers
- Nuclear Materials and Properties
- Gastroesophageal reflux and treatments
- Fusion materials and technologies
- Intracerebral and Subarachnoid Hemorrhage Research
Nanjing Polytechnic Institute
2025
West China Hospital of Sichuan University
2013-2024
Sichuan University
2014-2024
Affiliated Hospital of Jining Medical University
2024
Huashan Hospital
2024
Fudan University
2024
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2014-2024
State Key Laboratory of Biotherapy
2021-2022
China Academy of Engineering Physics
2020-2021
Peking Union Medical College Hospital
2020
Acute kidney injury (AKI) is a common complication among patients with the novel coronavirus (COVID-19). COVID-19 along AKI usually resulted in poor prognosis for those affected. Remdesivir antiviral drug that was urgently approved treatment of COVID-19. In current study, safety data remdesivir were limited. We gathered information on cases adverse events reported to U.S. Food and Drug Administration (US FDA) Adverse Event Reporting System (FAERS) database. employed reporting odds ratio...
Proton pump inhibitors (PPIs) were widely used. Observational studies suggested increasing risk of kidney injury in patients with PPIs treatment. We gathered six PPI regimens and adverse reports acute (AKI) chronic disease (CKD) based on US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2019. employed reporting odds ratio (ROR) detect signals. Finally, we identified 3187 PPIs-associated AKI cases 3457 CKD cases. detected significant signals between as well CKD. The signal...
Background Change of direction (COD) skills are crucial for athletic performance in sports such as table tennis. Improving COD can enhance overall agility and responsiveness during competition. Objective To investigate the effects an 8-week multi-directional movement training combined with balance on young tennis players. Methods Thirty players from same team were randomly assigned to two groups: group (MB, n = 15) control (CON, 15). The MB underwent unstable surfaces, while CON performed...
Abstract Proton pump inhibitor (PPI) was widely used around the world. Studies suggested conflicting results between PPI treatment and dementia event. This study examined association six agents event by mining US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2020. We employed proportional reporting ratio (PRR) information element (IC) methods detect signals of relevant PPI. also analyzed characteristics positive control reports, compared long- short-duration treatment....
Neuroinflammation is considered an important step in the progression of secondary brain injury (SBI) induced by cerebral hemorrhage (ICH). The nucleotide-binding and oligomerization structural domain-like receptor family pyridine domain-containing 3 (NLRP3) inflammasomes play role immune pathophysiology SBI. Febuxostat (Feb) a xanthine oxidase inhibitor that approved for treatment gout has been found to have potent anti-inflammatory effects. However, it less studied after ICH we aimed...
Background: Antidepressants are widely used to manage depression and other psychiatric diseases. A previous study revealed that hepatotoxicity was the main adverse event related antidepressants. Therefore, drug-induced liver injury (DILI) caused by antidepressants deserves more attention. Objectives: To investigate DILI events reported due antidepressant use in United States Food Drug Administration Adverse Events Reporting System (FAERS) database. Research design: disproportionality...
Abstract Background: Procalcitonin (PCT) is an early, sensitive, and accurate marker for diagnosing infection sepsis. As sepsis septic shock are dominant causes of acute kidney injury (AKI), we investigated whether PCT early predictor AKI in patients with symptoms infection. Methods: Between January 2011 October 2011, 1361 inpatients West China Hospital who displayed were enrolled our study. Levels PCT, serum amyloid A (SAA), C-reactive protein (CRP), interleukin-6 (IL-6), white blood cell...
The aim of this study was to investigate the correlation between genetic polymorphisms azathioprine-metabolizing enzymes and adverse reactions myelosuppression. To end, a retrospective analysis performed on 1,419 Chinese patients involving 40 different diseases 3 genes: ITPA (94C>A), TPMT*3 (T>C), NUDT15 (415C>T). Strict inclusion exclusion criteria were established collect relative cases, azathioprine myelosuppression evaluated by drug reaction criteria. mutation rates...
To investigate interstitial lung disease (ILD) in men with prostate cancer receiving hormone therapy.We gathered cases diagnosed based on the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database from 2004 to 2020. We divided included into 3 groups primary suspected drugs: a therapy group, positive control group (taxanes), negative group. employed reporting odds ratio, disproportionality method, detect association between ILD events target drugs.We...
Concerns regarding statin-related neurocognitive disorders have emerged in recent years. However, previous studies reported inconsistent results. We evaluated the association between statins and using FDA Adverse Event Reporting System (FAERS).
The aim of this study was to evaluate the association between CDK4/6 inhibitors and QT interval prolongation (QTp) Torsades de Pointes (TdP) in breast cancer patients.
Levodopa-induced dyskinesia (LID) is an intractable motor complication arising in Parkinson's disease with the progression of and chronic treatment levodopa. However, specific cell assemblies mediating have not been fully elucidated. Here, we utilize activity-dependent tool to identify three brain regions (globus pallidus external segment [GPe], parafascicular thalamic nucleus, subthalamic nucleus) that specifically contain dyskinesia-activated ensembles. An intensity-dependent hyperactivity...
Statins were regarded as a main medication for managing hypercholesterolemia. Administration of statin therapy could reduce the incidence cardiovascular disease in individuals diagnosed with type 2 diabetes mellitus (DM), which was recognized by multipal clinical guidelines. But previous studies had conflicting results on whether long-term use statins benefit renal function diabetic patients.
Abstract Objectives The purpose of this study was to describe the level, preventability and categories adverse events (AEs) in Chinese geriatric patients identified by medical record review using Global Trigger Tool. applicability GTT also assessed explore possible modifications for trigger tools. Methods conducted at a 4300‐bed tertiary teaching hospital. Twenty randomly‐selected records over 60 were reviewed every 2 weeks from January 1 2015 December 31st, 2015. We studied 480 total. Two...