A5100414422- Nutrition and Health in Aging
- Frailty in Older Adults
- Asthma and respiratory diseases
- Cardiac Ischemia and Reperfusion
- Alcohol Consumption and Health Effects
- Health Systems, Economic Evaluations, Quality of Life
- Chemotherapy-induced organ toxicity mitigation
- Smoking Behavior and Cessation
- Bone health and osteoporosis research
- Diet and metabolism studies
- Vitamin D Research Studies
- Body Composition Measurement Techniques
- Diet, Metabolism, and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Muscle Physiology and Disorders
- Anesthesia and Neurotoxicity Research
- Tea Polyphenols and Effects
- Chemotherapy-induced cardiotoxicity and mitigation
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Pharmacovigilance and Adverse Drug Reactions
- Allergic Rhinitis and Sensitization
Chinese Academy of Sciences
2009-2025
Shenzhen Institutes of Advanced Technology
2025
Sichuan University
2007-2024
West China Hospital of Sichuan University
2013-2024
Tongji University
2010-2024
Tongji Hospital
2010-2024
XinHua Hospital
2024
Shanghai Jiao Tong University
2024
Fudan University
2024
Huadong Hospital
2024
Sarcopenia is the age-related loss of skeletal muscle mass and strength or physical function. It most common in elderly individuals. Due to its high incidence, insidious onset, extensive impact on body, it has a huge family medical burden social public health expenditure China. The understanding sarcopenia China still lacking, recommendations for prevention, control, intervention are not clear unified. purpose this consensus report standardize methods patients China; improve efficacy...
Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare.78 patients undergoing functional endoscopic sinus were followed-up 8 years and classified into recurrent non-recurrent groups. A cluster analysis based inflammatory endotypes was performed, secondarily matched phenotypes.The rate Southwest 21.8% over post-surgery. The 4 clusters: 1...
Platycodin D (PD) is the main active saponin of Platycodon grandiflorum (PG) and reported to exhibit multiple biological effects, including anti-tumor, anti-inflammation, anti-obesity properties. Although recently there have been many research reports on chemical constituents plant's roots, only few works aerial parts PG. In present study, we report first isolation PD from PG its protective effect against acute alcohol-induced liver oxidative injury inflammatory response in mice. brief, was...
Purpose: The aim of this study was to assess the prevalence sarcopenia and depressive symptoms estimate association between them in elderly Chinese community-dwelling individuals. Patients methods: A total 948 individuals were recruited through leaflets posters from three communities Chengdu, 865 participants analyzed cross-sectional study. Muscle mass measured using bioimpedance analysis, handgrip strength with a handheld dynamometer, physical performance assessed via usual gait speed on 6...
Abstract Objective Sarcopenia in older adults is closely related to vitamin D deficiency and reduced levels of physical activity, but little has been reported on the interaction between activity positive effects D. The purpose this study was explore interactive effect muscle mass function through animal experiments population surveys. Methods Male 4‐week‐old C57BL/6J mice were fed different purified diets: a D‐deficient diet (with increased calcium phosphorus prevent abnormal mineral muscle)...
The European Working Group on Sarcopenia in Older People (EWGSOP) recently published an updated version (EWGSOP2). We aimed to compare the predictive values of EWGSOP-defined and EWGSOP2-defined sarcopenia for incidence falls hospitalization older adults. defined according EWGSOP EWGSOP2. further modified cut-off points EWGSOP2 lowest quintile gender-specific distribution our study population, named "modified EWGSOP" EWGSOP2", respectively. included 384 participants. During follow-up, 98...
This study aimed to evaluate the association between skeletal muscle mass and long-term all-cause mortality among nonagenarians centenarians in China. We used data from Project of Longevity Aging Dujiangyan (PLAD). A total 738 community-dwelling people aged ≥ 90 years (mean age 93.5 ± 3.2 years) were analyzed this study. The appendicular (ASM) was estimated using a previously validated anthropometric equation. information on survival status requested local government registries during 4 year...
Abstract A randomized, active‐controlled clinical trial was conducted to examine the effect of pulsed electromagnetic fields (PEMFs) on women with postmenopausal osteoporosis (PMO) in southwest China. Forty‐four participants were randomly assigned receive alendronate or one course PEMFs treatment. The primary endpoint mean percentage change bone mineral density lumbar spine (BMDL), and secondary endpoints changes left proximal femur (BMDF), serum 25OH vitamin D3 (25(OH)D) concentrations,...
Although kidney injury caused by cisplatin has attracted much attention, cisplatin-induced cardiotoxicity is elusive. Our previous studies have confirmed that saponins (ginsenosides) from Panax quinquefolius can effectively reduce acute renal injuries. current study aimed to identify the potential effects of leaves P. (PQS) on cisplatin-evoked cardiotoxicity.Mice were intragastrically with PQS at doses 125 and 250 mg/kg daily for 15 days. The mice in group + groups received four times...
Steroidogenic factor (SF)-1 and its downstream target genes involved in estrogen signaling are aberrantly expressed ovarian endometriosis. Our objective was to explore the microRNA-mediated mechanism controlling aberrant SF-1 expression Bioinformatics analysis predicted that microRNA23a microRNA23b (miR23a/b) NR5A1 3′-untranslated region. We investigated relative spatial distribution of miR23a/b analyzed relationship between endometriotic tissues. The study conducted at Department Gynecology...
Cisplatin is an effective anticancer chemotherapeutic agent, but the use of cisplatin in clinic severely limited by side effects. Nephrotoxicity a major factor that contributes to effects chemotherapy. The aim this research was survey nephroprotective anthocyanin from fruits Panax ginseng (GFA) murine model cisplatin‐induced acute kidney injury. We observed pretreatment with GFA attenuated elevations blood urea nitrogen and creatinine levels histopathological injury induced cisplatin....
The carbohydrate-insulin model predicts that meals with varying glycemic indices will elicit distinct metabolic and hunger responses, including greater intake at subsequent following high-glycemic-index meals. To test this, a randomized trial (NCT05804942) was conducted in healthy adults using intervention low, medium, high constant macronutrient composition. After of the meals, glucose insulin followed predicted pattern, but subjective did not. At group level, low index led to lower energy...
Inhibition of translocator protein (18 kDa) (TSPO) can effectively prevent reperfusion-induced arrhythmias and improve postischemic contractile performance. Mitochondrial permeability transition pore (mPTP) opening, mediated mainly through oxidative stress during ischemia/reperfusion (I/R), is a key event in reperfusion injury. 4′-Chlorodiazepam widely used TSPO antagonist. However, whether 4′-chlorodiazepam cardiac functional recovery postischemia by affecting enzymes, reducing reactive...
Alcoholic liver disease (ALD) has become an important hazard to public and personal health. Oxidative stress is believed be responsible for the pathological changes in ALD. Previous studies have showed that insulin, a classic regulator of glucose metabolism, significant anti-oxidative function plays role maintaining redox balance. For addressing effects mechanisms insulin pre-administration on ethanol-induced oxidative injury, we investigated histopathology, inflammatory factors, apoptosis,...