Abstract Proton pump inhibitor (PPI) was widely used around the world. Studies suggested conflicting results between PPI treatment and dementia event. This study examined association six agents event by mining US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2020. We employed proportional reporting ratio (PRR) information element (IC) methods detect signals of relevant PPI. also analyzed characteristics positive control reports, compared long- short-duration treatment....

Abstract Background Older adults with dementia often face the risk of potentially inappropriate medication (PIM) use. The quality PIM evaluation is hindered by researchers' unfamiliarity criteria for drug While traditional machine learning algorithms can enhance quality, they struggle multilabel nature prescription data. Aim This study aimed to combine six and three classification models identify correlations in information develop an optimal model PIMs older dementia. Method was conducted...

An accurate prediction of the hepatotoxicity associated with low-dose methotrexate can provide evidence for a reasonable treatment choice. This study aimed to develop machine learning-based model predict and explore risk factors. Eligible patients immune system disorders, who received at West China Hospital between 1 January 2018, 31 December 2019, were enrolled. A retrospective review included was conducted. Risk factors selected from multiple patient characteristics, including...

Abstract Objectives The purpose of this study was to describe the level, preventability and categories adverse events (AEs) in Chinese geriatric patients identified by medical record review using Global Trigger Tool. applicability GTT also assessed explore possible modifications for trigger tools. Methods conducted at a 4300‐bed tertiary teaching hospital. Twenty randomly‐selected records over 60 were reviewed every 2 weeks from January 1 2015 December 31st, 2015. We studied 480 total. Two...

Due to multiple comorbid illnesses, polypharmacy, and age-related changes in pharmacokinetics pharmacodynamics older adults, the prevalence of potentially inappropriate medications (PIMs) is high, which affects quality life adults. Building an effective warning model necessary for early identification PIMs prevent harm caused by medication geriatric patients. The purpose this study was develop a machine learning-based Chinese outpatients. This retrospective conducted among outpatients nine...

Abstract Objectives Due to multiple comorbidillnesses, polypharmacy, and age-related changes in pharmacokinetics pharmacodynamics older adults, the prevalence of potentially inappropriate medications (PIMs) is high, which affects quality life adults. Building an effective warning model necessary for early identification PIMs prevent harm caused by medication geriatric patients. The purpose this study was develop a machine learning-based Chinese outpatients. Method This retrospective...

The traditional MOPSO algorithm has the disadvantage that convergence is poor when multi-objective optimization task processed, and locally optimal solution easy to fall into local solution. Therefore, an improved proposed. A double search strategy adopt improve convergence, where particles learns individual position in early iteration global late iteration. migration mechanism used communication ability of external archive. Finally, proposed operation ethylene cracking furnace. experimental...

To improve the accuracy of potentially inappropriate medication (PIM) prediction, a PIM prediction model that combines knowledge graph and machine learning was proposed.Firstly, based on Beers criteria 2019 using as basic structure, representation framework with logical expression capabilities constructed, inference process implemented from patient information nodes to nodes. Secondly, for each label established classifier chain algorithm, learn potential feature associations data. Finally,...

Background: The Global Trigger Tool(GTT)is an efficient and reliable method for possible adverse drug events(ADEs)identification of inpatient hospital records using triggers. purposes the study are to develop a trigger tool detect ADEs Chinese geriatric inpatients Delphi method. Methods: Three steps were used tool. First, researchers conducted comprehensive literature review existing triggers(adult or elderly)to formed initial triggers process. Second, group clinical experts, including...

AIM: Proton pump inhibitors (PPIs) were widely used around the world. Studies suggested conflicting results between PPIs treatment and risk of dementia. This study examined association dementia by mining US FDA Adverse Event Reporting System (FAERS) database. METHODS: We identified six PPI agents adverse reports based on FAERS database from 2004 to 2019. employed reporting odds ratio (ROR) proportional (PRR) detect signals relevant PPIs. also analyzed characteristics reports, compared events...

Abstract Purpose An accurate prediction of the hepatotoxicity associated with low-dose methotrexate can provide evidence for a reasonable treatment choice. This study aimed to develop machine learning-based model predict and explore risk factors. Methods Eligible patients immune system disorders, who received at West China Hospital between January 1, 2018, December 31, 2019, were enrolled. A retrospective review included was conducted. Risk factors selected from multiple patient...