A5108049551- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Statistical Methods in Clinical Trials
- Colorectal and Anal Carcinomas
- High Altitude and Hypoxia
- Sarcoma Diagnosis and Treatment
- Heart Failure Treatment and Management
- HER2/EGFR in Cancer Research
- Congenital Diaphragmatic Hernia Studies
- Diabetes Treatment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anorectal Disease Treatments and Outcomes
- Gestational Trophoblastic Disease Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- Gastric Cancer Management and Outcomes
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
First Affiliated Hospital of Wenzhou Medical University
2024
City of Hope
2020-2024
The University of Queensland
2024
Wenzhou Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2023
Sichuan University
2017-2023
West China Hospital of Sichuan University
2017-2023
Chengdu Women's and Children's Central Hospital
2023
Betta Pharmaceuticals (China)
2023
Fujian Medical University
2023
Objective Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have significantly improved clinical effects on glycemic control. However, real-world data concerning the difference in gastrointestinal adverse events (AEs) among different GLP-1 RAs are still lacking. Our study aimed to characterize and compare AEs marketed (exenatide, liraglutide, dulaglutide, lixisenatide, semaglutide) based data. Methods Disproportionality analysis was used evaluate association between events. Data were...
Background: Clinical trials frequently reported anaplastic lymphoma kinase tyrosine inhibitors (ALK-TKIs) associated with cardiac adverse drug events (AEs) but minimal postmarketing data. We aimed to research real-world disorders ALK-TKIs based on the Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: Extract reports from FAERS first quarter of 2016 second 2021 were obtained. Data mining was carried out using disproportionality analysis determine clinical...
We aimed to explore the protective effects and potential treatment mechanism of Epigallocatechin-3-gallate (EGCG) in an animal model chronic exposure a natural high-altitude hypoxia (HAH) environment. Behavioral alterations were assessed with Morris water maze test. Iron accumulation hippocampus was detected by using DAB enhanced Perls' staining, MRI, qPCR colorimetry, respectively. Oxidative stress (malondialdehyde, MDA), apoptosis (Caspase-3), neural regeneration (brain-derived...
Dietary copper supplementation reverses pressure overload-induced cardiac hypertrophy by replenishment in the heart. A copper-selective chelator, trientine (triethylenetetramine [TETA]), left ventricular associated with diabetes also The present study was undertaken to address critical issue how TETA delivers Adult male Sprague-Dawley rats were subjected transverse aortic constriction (TAC) induce hypertrophy. Eight weeks after TAC surgery, developed and content heart reduced. then...
To investigate interstitial lung disease (ILD) in men with prostate cancer receiving hormone therapy.We gathered cases diagnosed based on the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database from 2004 to 2020. We divided included into 3 groups primary suspected drugs: a therapy group, positive control group (taxanes), negative group. employed reporting odds ratio, disproportionality method, detect association between ILD events target drugs.We...
Introduction: To study the effects of drug-induced CYP2D6 activity inhibition and genetic polymorphisms on fluoxetine metabolism, rat liver microsomes (RLMs) SD rats were used to investigate potential drug‒drug interactions (DDIs), http://muchong.com/t-10728934-1 recombinant baculosomes prepared subjected catalytic reactivity studies. Methods Results: All analytes detected by ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‒MS/MS). After screening for 27 targeted natural...
Inflammatory myofibroblastic tumour (IMT) is an intermediate neoplasm and rarely occurs in the liver. The aim of this study was to analyse clinicopathological genetic features largest primary hepatic IMT.A total 10 cases were identified (four males six females aged 1-48 years, median = 35 years) from 2011 2021, which accounted for 2.5% IMTs occurring all organ systems. Histological findings revealed that myofibroblastic/fibroblastic cells with inflammatory infiltration focal hypocellularity...
Exposure to hypobaric hypoxia (HH) environment causes stress the body, especially oxygen-consuming organs. Chronic HH conditions have adverse effects on myocardium. Thus, we conducted this experiment and aim evaluate such explore therapeutic role of epigallocatechin-3-gallate (EGCG) in rats' heart under chronic conditions. For that purpose, transported rats from plain a real at high altitude for establishing model. At altitude, animals were treated with EGCG while salidroside was used as...
Background Lung cancer is imposing significant pressure on the national health insurance system worldwide, especially under COVID-19 pandemic. However, cost-effectiveness of all available first-line treatments for patients with advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung (NSCLC) still uncertain. The aim this study was to evaluate 12 EGFR NSCLC from perspective United Kingdom (UK) National Health Service and Chinese care system. Methods We used a Markov model...
Background Right heart failure may lead to impaired liver perfusion and venous congestion, resulting in different extents of fibrosis. However, whether hepatic tissue deterioration determined by native T1 mapping extracellular volume fraction using cardiac magnetic resonance imaging is associated with poor outcomes patients pulmonary arterial hypertension remains unclear. Methods Results A total 131 participants (mean age, 36±13 years) 64 healthy controls 44±18) between October 2013 December...
Oncology has become more reliant on new testing methods and a greater use of electronic medical records, which provide plethora information available to physicians researchers. However, take advantage vital clinical research data for precision medicine, we must initially make an effort create infrastructure the collection, storage, utilization this with uniquely designed disease-specific registries that could support collection large number patients.In study, perform in-depth analysis series...
Abstract Background Infection is one of the most common causes death in patients with hematological malignancies during chemotherapy. Due to its special location, local warmth and humidity, repeated pollution stool urine, characteristically wrinkled anatomical structure within which bacteria can hide, perianal becomes a site high incidence infection. Such infection also has recurrence rate mortality, increasing economic burden patients, delaying time treatment reducing quality life. In...
The aim of this study was to evaluate the prognostic value for survival parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in patients with nasopharyngeal carcinoma (NPC).Baseline IVIM-DWI performed on 97 newly diagnosed NPC prospective study. relationships between pretreatment parametric values (apparent diffusion coefficient (ADC), D, D*, and f) primary tumors patients' 3-year were analyzed who received chemoradiotherapy. cutoff IVIM local...
The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4 within the 12q13-15 chromosomal region. FRS2 was recently found be consistently amplified in atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDL) dedifferentiated (DDL), suggesting detection of amplification could a diagnostic tool for ALT/WDL/DDLs. However, expression protein value immunohistochemistry (IHC) has not been evaluated large cohort ALT/WDL/DDLs.A SNOMED search...