A5070665630- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Elasticity and Material Modeling
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Internet of Things and Social Network Interactions
- melanin and skin pigmentation
- Cardiovascular Disease and Adiposity
- Educational Technology and Assessment
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Barrier Structure and Function Studies
- Ophthalmology and Eye Disorders
- Web Applications and Data Management
- Ethics and Social Impacts of AI
- Workplace Spirituality and Leadership
- Synthesis of Organic Compounds
- Head and Neck Cancer Studies
- Biofield Effects and Biophysics
- Elevator Systems and Control
- Banking, Crisis Management, COVID-19 Impact
- Vascular Anomalies and Treatments
Mallinckrodt (United States)
2009-2023
Jiangsu Cancer Hospital
2023
Nanjing Medical University
2023
Tianjin Medical University
2020-2022
Washington University in St. Louis
2010-2019
Gaochun People's Hospital
2019
Soochow University
2019
Donghua University
2018
Southeast University
2017
Emory University
2017
In this paper, a modeling approach combining <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> xmlns:xlink="http://www.w3.org/1999/xlink">vivo</i> intravascular ultrasound (IVUS) imaging, computational modeling, angiography, and mechanical testing is proposed to perform analysis for human coronary atherosclerotic plaques potential more accurate plaque vulnerability assessment. A 44-slice IVUS dataset of was acquired from one patient, four 3-D...
This article seeks to investigate the mediating effect of thriving at work between perceived empowering leadership behavior and employee performance. The proposed hypotheses were tested with structure equation modeling (SEM) techniques via AMOS 21. data was collected from employees Big Four bank branches in Shanghai; thus, future research is encouraged collect different respondents sectors. results this study indicated that plays a vital role turn, influenced their performances. Also,...
To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.Eighteen T2DM and nine healthy monkeys were studied. Echocardiography was performed for function classification. Cardiac magnetic resonance (CMR) imaging to obtain extracellular volume fraction (ECV) maps T1ρ at two spin-locking frequencies. ECV values, index (mFI) values which are based on the dispersion T1ρ, calculated....
Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets to zero when is under resolution limit IVUS does not see it. An innovative modeling approach combining optical coherence tomography (OCT) introduced quantification more accurate calculations. In vivo OCT coronary data were acquired with informed consent obtained. images merged form the + set, biplane angiography...
Objective: Whether blood-brain barrier (BBB) disruption induced by chronic spontaneous hypertension is associated with beta-amyloid (Aβ) accumulation in the brain remains poorly understood.The purpose of this study was to investigate relationship between BBB and Aβ influx aged rats hypertension.Materials Methods: Five spontaneously hypertensive (SHRs) five age-matched normotensive Wistar-Kyoto (WKY) were studied.The volume transfer constant (K trans ) obtained from dynamic contrast-enhanced...
Left ventricular aneurysm (LVA) is a significant complication of myocardial infarction that may lead to global left (LV) dysfunction. However, the exact mechanism underlying abnormal function has not been elucidated. In this study we tested hypothesis changes in LV geometry cause both an increase wall stress and change temporal distribution LVA border zone (BZ) during systole.Transmural anteroapical infarcts were created adult Dorsett sheep (n=8) allowed mature into LVAs for 10 weeks....
According to the World Health Organization, China is one of 22 countries with serious tuberculosis (TB) infections and 27 multidrug-resistant TB strains. Despite decline in overall population, healthcare workers (HCWs) are still at a high risk infection. Compared high-income countries, prevalence among HCWs higher low- middle-income countries. Low-dose computed tomography (LDCT) becoming more popular due its superior sensitivity lower radiation dose. However, there have been no reports about...
Abstract Background Coronary plaque vulnerability prediction is difficult because non-trivial to quantify, clinically available medical image modality not enough quantify thin cap thickness, methods with high accuracies still need be developed, and gold-standard data validate are often available. Patient follow-up intravascular ultrasound (IVUS), optical coherence tomography (OCT) angiography were acquired construct 3D fluid–structure interaction (FSI) coronary models four machine-learning...
Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged a superior way measure left ventricular (LV) function cardiac dysfunction, making it possible further evaluate early-stage LV spontaneous monkeys.Spontaneous with (T2DM-DD, n = 10) and corresponding nondiabetic healthy animals (ND, 9) were prospectively scanned for CMR study. Circumferential longitudinal...
Medical image resolution has been a serious limitation in plaque progression research. A modeling approach combining intravascular ultrasound (IVUS) and optical coherence tomography (OCT) was introduced patient follow-up IVUS OCT data were acquired to construct three-dimensional (3D) coronary models for investigations. Baseline vivo from one with 105 matched slices selected model construction. 3D fluid-structure interaction (FSI) based on (denoted as + model) constructed obtain stress/strain...
Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling.APT102, a soluble human recombinant ecto-nucleoside triphosphate diphosphohydrolase-1, can hydrolyze extracellular nucleotides to attenuate their prothrombotic proinflammatory effects.The purpose this study was temporally evaluate the therapeutic effect APT102 on IRI rats...
Exposure to hypobaric hypoxia (HH) environment causes stress the body, especially oxygen-consuming organs. Chronic HH conditions have adverse effects on myocardium. Thus, we conducted this experiment and aim evaluate such explore therapeutic role of epigallocatechin-3-gallate (EGCG) in rats' heart under chronic conditions. For that purpose, transported rats from plain a real at high altitude for establishing model. At altitude, animals were treated with EGCG while salidroside was used as...
Accurate stress and strain calculations are important for plaque progression vulnerability assessment. Models based on in vivo data often need to form geometries with zero-stress/strain conditions. The goal of this paper is use IVUS-based near-idealized introduce a three-step model construction process include residual stress, axial shrinkage, circumferential shrinkage investigate their impacts calculations. In Vivo intravascular ultrasound (IVUS) human coronary were acquired construction....
Abstract Several image-based computational models have been used to perform mechanical analysis for atherosclerotic plaque progression and vulnerability investigations. However, differences of predictions from those not quantified at multi-patient level. In vivo intravascular ultrasound (IVUS) coronary data were acquired seven patients. Seven 2D/3D with/without circumferential shrink, cyclic bending fluid–structure interactions (FSI) constructed the patients model comparisons quantify impact...
The design and development of multifunctional nanoparticles have attracted great interest in biomedical research. This study aims to prepare pH-responsive melanin-like for
Abstract Background To screen the single nucleotide polymorphisms (SNPs) in coding regions of VANGL and FZD family members related to plane cell polarity (PCP) signaling pathway neural tube defects (NTDs) patients, so as provide theoretical experimental basis for prevention treatment NTDs by intervening PCP signal transduction. Methods 112 patients were collected case group craniocerebral trauma control. Afterwards, blood genomic DNA was extracted sequenced. The distribution SNP alleles...
Synthetic Lethal (SL) relationships, though rare among the vast array of gene combinations, hold substantial promise for targeted cancer therapy. Despite advancements in AI model accuracy, there is still a significant need domain experts interpretive paths and mechanism explorations that align better with domain-specific knowledge, particularly due to high costs experimentation. To address this gap, we propose an iterative Human-AI collaborative framework two key components: 1) Human-Engaged...