A5100711882- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Cancer Immunotherapy and Biomarkers
- High Altitude and Hypoxia
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Micro and Nano Robotics
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
Shanghai Tenth People's Hospital
2022-2025
Tongji University
2022-2025
Sir Run Run Shaw Hospital
2023-2025
Second Affiliated Hospital of Zhejiang University
2023-2024
Central South University
2019-2024
Third Xiangya Hospital
2021-2024
Ningbo University
2023-2024
Ningbo First Hospital
2024
ShanghaiTech University
2023-2024
Sichuan University
2018-2024
Abstract Mouse cortical radial glial cells (RGCs) are primary neural stem that give rise to oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There fundamental gaps understanding how these diverse cell subtypes generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show beginning at around E16.5, neocortical RGCs start generate ASCL1 + EGFR apical multipotent intermediate progenitors (MIPCs), which then...
Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for regeneration, how to balance the biochemical physical microenvironment in OA remains big challenge. In this study, bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) ROS scavenging regeneration has developed. The prepared bioscaffold...
Abstract Biological fluids, the most complex blends, have compositions that constantly vary and cannot be molecularly defined 1 . Despite these uncertainties, proteins fluctuate, fold, function evolve as programmed 2–4 We propose in addition to known monomeric sequence requirements, protein sequences encode multi-pair interactions at segmental level navigate random encounters 5,6 ; synthetic heteropolymers capable of emulating such can replicate how behave biological fluids individually...
Abstract This study investigates the cardioprotective effects of Paeoniflorin (PF) on left ventricular remodeling following acute myocardial infarction (AMI) under conditions hypobaric hypoxia. Left post-AMI plays a pivotal role in exacerbating heart failure, especially at high altitudes. Using rat model AMI, aimed to evaluate potential PF Ninety male rats were divided into four groups: sham-operated controls normoxia/hypobaria, an AMI group, and treatment group. was administered for 4 weeks...
Diagnosis and stratification of prostate cancer (PCa) patients using the prostate-specific antigen (PSA) test is challenging. Extracellular vesicles (EVs), as a new star liquid biopsy, has attracted interest to complement inaccurate PSA screening invasiveness tissue biopsy. In this study, panel potential small EV (sEV) protein biomarkers identified from PCa cell lines label-free LC-MS/MS proteomics. These underwent further validation with plasma urine samples different stages through...
The electrochemiluminesce (ECL) efficiency of luminous emitter can be enhanced by the means resonance energy transfer (ECL-RET) with a matched donor. However, generally, donor and acceptor pairs were separated in different independent nanostructures, experiencing challenging issues limited stability. Herein, we designed novel ECL-RET model within one nanostructure containing tris(4,4′-dicarboxylicacid-2,2′-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+) CdSe@ZnS quantum dots (QDs) for...
Magnetic nanomotors (MNMs), powered by a magnetic field, are ideal platforms to achieve versatile biomedical applications in collective and spatiotemporal fashion. Although the programmable swarm of MNMs that mimics highly ordered behaviors living creatures has been extensively studied at microscale, it is vital importance manipulate MNM swarms nanoscale for on-demand tasks cellular level. In this work, Cy5-tagged caspase-3-specific peptide-modified designed, adaptive control revealed...
Although biologics have been revolutionizing the treatment of inflammatory bowel diseases (IBD) over past decade, a significant number patients still fail to benefit from these drugs. Overcoming nonresponse is one top challenges in IBD treatment. In this study, we revealed that hyaluronan (HA), an extracellular matrix (ECM) component gut, associated with nonresponsiveness infliximab and vedolizumab therapy IBD. murine colitis models, inhibition HA synthase 2–mediated (HAS2-mediated)...
Studies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis causal associations microbiota, metabolites, cytokines with cancer Asian population. Genome-wide association study (GWAS) summary datasets were collected from public databases. There 418 bacterial traits, 452 91 cytokines, 5408 cases East Asia, 109,347 controls included. Mendelian randomization (MR) analyses performed investigate their...
The abnormal mechanical microenvironment is a hallmark feature of solid tumors and plays key role in immunotherapy resistance. actin cytoskeleton can be finely tuned to control cell mechanics, which becomes central target regulate the tumor (TMME). Here, we propose an actin-binding protein-modified magnetic nanomotor (ABP-MN) coupled with rotating field (MF) dynamically for remodeling TMME. ABP-MNs, ultrasmall diameter 23 nm, intracellularly induce depolymerization via magneto-mechanical...
Neural stem cells in the subventricular zone (SVZ) of lateral ventricle generate new interneurons, which migrate tangentially through rostral migratory stream (RMS) to olfactory bulb (OB). The PROK2 (prokineticin 2) and PROKR2 receptor signaling pathway has been identified cause human Kallmann syndrome, a developmental disease that associates hypogonadism with anosmia (OB defects). However, identities properties PROK2+ PROKR2+ SVZ-RMS-OB remain largely unknown. Here we examine expression...
The tumor microenvironment (TME) plays a crucial role in cancer progression and recent evidence has clarified its clinical significance predicting outcomes efficacy. However, there are no studies on the systematic analysis of TME characteristics bladder cancer. In this study, we comprehensively evaluated invasion pattern 1,889 patients, defined three different phenotypes, found that subtypes were associated with prognosis pathological We further explored signaling pathways, cancer-immunity...
Background: Neuroinflammation is a frequent cause of brain damage after intracerebral hemorrhage (ICH). Gut microbiota are reported to regulate neuroinflammation. Berberine has been found have anti-inflammatory actions, including in the central nervous system. However, it not known whether berberine regulates neuroinflammation ICH, nor relationship between antineuroinflammatory actions and gut ICH understood. Methods: was induced male mice by collagenase injection. Immunofluorescent staining...
Invadopodium formation is a crucial early event of invasion and metastasis hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying regulation invadopodia remain elusive. This study aimed to investigate potential role discs large homolog 5 (Dlg5) in invadopodium function HCC. We found that Dlg5 expression was significantly lower human HCC tissues cell lines than adjacent nontumor liver cells. Lower associated with advanced stages HCC, poor overall disease‐free survival...
Abstract Cortical interneurons are derived from the subcortical medial ganglionic eminence (MGE), caudal (CGE) and preoptic area (POA). CGE‐derived cortical interneurons, which comprise around 30% of all mainly express Htr3a, calretinin (CR), Reelin (RELN) vasoactive intestinal polypeptide (VIP). In present study, we show that transcription factors Sp8 Sp9 co‐expressed in subventricular zone (SVZ) dorsal CGE. Conditional knockout Sp8/9 using Gsx2‐Cre transgenic line results severe loss...