A5034690941- Micro and Nano Robotics
- Electrohydrodynamics and Fluid Dynamics
- Catalysis for Biomass Conversion
- Viral gastroenteritis research and epidemiology
- Functional Brain Connectivity Studies
- Drug-Induced Hepatotoxicity and Protection
- Dementia and Cognitive Impairment Research
- Genomics and Chromatin Dynamics
- Molecular Communication and Nanonetworks
- Gastroesophageal reflux and treatments
- vaccines and immunoinformatics approaches
- Membrane Separation Technologies
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticles: synthesis and applications
- Healthcare Systems and Public Health
- Extracellular vesicles in disease
- Employment and Welfare Studies
- Financial Crisis of the 21st Century
- Aortic aneurysm repair treatments
- Action Observation and Synchronization
- Vascular anomalies and interventions
- Software System Performance and Reliability
- Angiogenesis and VEGF in Cancer
- Biochemical and Structural Characterization
- Machine Learning in Bioinformatics
Affiliated Hospital of Southwest Medical University
2024-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Society of Nuclear Medicine and Molecular Imaging
2025
First Affiliated Hospital of Sichuan Medical University
2024
Tongji University
2010-2024
Frontier Science Foundation
2024
Tongji Hospital
2015-2023
Shanghai Pulmonary Hospital
2020-2022
State Key Laboratory of Pollution Control and Resource Reuse
2017-2022
Abstract Mental disorders are the leading contributors to globally nonfatal burden of disease. This study was aimed estimate mental in Asian countries. Based on GBD 2019, prevalence and disability-adjusted life years (DALYs) rates with 95% uncertainty intervals (UI) were estimated Predictions for future 8 selected countries, ranks correlations Sociodemographic Index (SDI) also estimated. During past 3 decades, while number DALYs increased from 43.9 million (95% UI: 32.5–57.2) 69.0...
Abstract New‐era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, precise locomotion control in a manner are key parameters design complex bio‐environment. In this work, biomimetic magnetic microrobot (BMM) inspired by magnetotactic bacteria (MTB) with speedy motion response accurate positioning is developed targeted thrombolysis. Similar magnetosome...
Magnetic nanomotors (MNMs), powered by a magnetic field, are ideal platforms to achieve versatile biomedical applications in collective and spatiotemporal fashion. Although the programmable swarm of MNMs that mimics highly ordered behaviors living creatures has been extensively studied at microscale, it is vital importance manipulate MNM swarms nanoscale for on-demand tasks cellular level. In this work, Cy5-tagged caspase-3-specific peptide-modified designed, adaptive control revealed...
Spatial Epitope Prediction server for Protein Antigens (SEPPA) has received lots of feedback since being published in 2009. In this improved version, relative ASA preference unit patch and consolidated amino acid index were added as further classification parameters addition to unit-triangle propensity clustering coefficient which previously reported. Then logistic regression model was adopted instead the previous simple additive one. Most importantly, subcellular localization protein...
Statins, as an important class of lipid-lowering drugs, play a key role in the prevention and treatment cardiovascular diseases. However, with their widespread use clinical practice, some adverse events have gradually emerged. In particular, hepatotoxicity associated statins has become one concerns that require sufficient attention. this study, we conducted comprehensive detailed analysis based on data US Food Drug Administration Adverse Event Reporting System database from first quarter...
This study aims to identify and evaluate the most common drugs associated with risks of autoimmune hepatitis (AIH) using FDA Adverse Event Reporting System (FAERS) database. drug events (ADEs) drug-induced AIH (DI-AIH) were retrieved from FAERS database (January 2004–June 2024). Disproportionality analysis was performed significantly linked DI-AIH, time-to-onset (TTO) analyses conducted timing risk profiles DI-AIH adverse reactions. Our identified 2,511 ADEs hepatitis. 22 risk, including 4...
The central pathology causing idiopathic focal dystonia remains unclear, limiting effective treatment targets. recently identified somato-cognitive action network (SCAN) with its role in coordinating physiologic processes and coarse movements has been implicated dysfunction. SCAN is thought to interface between the phylogenetically newer primary motor regions that control fine cingulo-opercular (CON) putatively conveys cognitive intentions for action. We hypothesized effector-agnostic nature...
Our study aimed to report the burden of diseases attributable high body mass index (BMI) in Asia from 1990 2019. Utilizing data Global Burden Disease (GBD) Study 2019, we calculated disability-adjusted life years (DALYs) and deaths, with trends quantified by estimated annual percentage change (EAPC). We also made projections for selected countries relationship between Sociodemographic Index (SDI) BMI-related disease burden. From observed significant increases absolute number deaths DALYs,...
In this work, a new type of modified β zeolites with rare earth elements (ree) was discovered for producing lactic acid from glucose and achieved good catalytic effect. At first, the performances ree-β zeolites, ree oxides, single-transition-metal-β were compared, result showed that Y-β Yb-β had best activity under same reaction conditions. Under conditions, maximum yields catalysts 45.3 43.6%, respectively. The characterization Y/Yb-β similar number Lewis sites as Sn-β they also more than...
Endometrial cancer had a relatively high prevalence of MMR deficiency. MMR-D/MSI-H endometrial patients are suggested to be potential beneficiaries PD-1/PD-L1 inhibitor therapy. Here, we explored the prognostic value MSI subtype in and its correlation with immune environment. Based on expression clinical data 78 POLE, 123 299 Other EC samples from TCGA-UCEC project, found that tumors were identified more often early stage, lower age, better patient survival, enriched CD8+ T cells, regulatory...
Electroencephalographic (EEG) abnormalities are seen in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) characteristic features of impairment. The most common findings EEG AD MCI increased relative power slow oscillations (delta theta rhythms) decreased fast (alpha, beta gamma rhythms). However, impairments processes not sufficiently reflected by brain oscillatory activity a particular frequency band. at high risk progressing to AD. Cross-frequency coupling (CFC),...
Abstract Background Cancer burden from the elderly has been rising largely due to aging population. However, research on long‐term epidemiological trends in cancer of is lacking. Methods Registry data this population‐based cross‐sectional study were Surveillance, Epidemiology, and End Results (SEER) database. The population aged 65 years or more, geographically distinct regions. Joinpoint regression JP Surv method used analyze survival. Mortality rate during 1975–2020 decreased 995.20 824.99...
Abstract Background: China is one of the countries with largest burden gastrointestinal and liver diseases (GILD) in world. The GILD constitutes various causes mortality disability. study aimed to investigate trend using Global Burden Diseases Study 2019 (GBD 2019) data resources from 1990 2019. Methods: on age-standardized rates (ASMR) disability-adjusted life years (DALYs) for were collected GBD resources. Furthermore, ranking main deaths DALYs, as well trends ASMR, lost (YLLs), due...
Magnetic nanorobots are emerging players in thrombolytic therapy due to their noninvasive remote actuation and drug loading capabilities. Although the with a size under 100 nm ideal apply microvascular systems, propulsion performance of is inevitably compromised limited response magnetic fields. Here, we demonstrate nattokinase-loaded vortex nanorobot (NK-MNR) an average around 70 high saturation magnetization for mechanical propelling thermal responsive thrombolysis field dual frequencies....
// Yi Sun 1, * , Wei Zhang Yunqin Chen 2 Qin Ma 3 Jia Qi Liu 1 Department of Central Laboratory, Shanghai Tenth People's Hospital, School Life Sciences and Technology, Tongji University, Shanghai, China R & D Information, AstraZeneca, Plant Science, South Dakota State Brookings, SD, USA These authors contributed equally to this work Correspondence to: Liu, e-mail: qiliu@tongji.edu.cn Wei, Jenny.Wei@astrazeneca.com Keywords: drug response, sensitivity, resistance, cancer cell line,...
Objective Alzheimer’s Disease (AD) is a progressive condition characterized by cognitive decline. AD often preceded mild impairment (MCI), though the diagnosis of both conditions remains challenge. Early AD, and prediction MCI progression require data-driven approaches to improve patient selection for treatment. We used machine learning tool predict performance in neuropsychological tests based on functional connectivity using whole-brain connectome, an attempt identify network substrates...
Degradation of pollution for specific chemicals represents an optimal approach to high-strength wastewater treatment. One-pot selective conversion acrylonitrile acrylic acid in a hydrothermal system with NaOH as catalyst was carried out. The influence factors were evaluated, including initial concentration, reaction temperature, time and amount alkali. Experimental results showed that the highest yield (55%) obtained at concentration 3 × 103 mg/L, 300°C 90 s 1.0 M NaOH. To determine path,...
Abstract Background . As a class of naturally occurring nanoparticles with low immunogenicity and high biocompatibility, exosomes have become promising drug carrier for cancer therapy. However, their clinical applications remain challenge due to unsuitable donors, scalability, as well insufficient targeting ability. Here, we describe validate new strategy loading into exosomes. We developed folate-conjugated exosome (Co-Exo-FA) derived from nanocomplex-loaded Raw264.7 macrophages. This...
The photo-reduction of bromate (BrO3-) has attracted much attention as the carcinogenesis and genotoxicity BrO3- in drinking water. In this study, a heterojunction photocatalyst was developed by depositing Au nanoparticles (NPs) onto P25 TiO2 NPs through one-pot, solvent-thermal process. Due to unique properties Au, deposited on surface created Schottky barrier between metal semiconductor, leading an effective separation photo-generated charge carriers served electron sinks. Au/TiO2...
Microrollers hold great potential for biomedical applications its mobility and environmental adaptivity. Autonomous trajectory tracking is crucial microrollers to conduct medical tasks precisely safely in complex unstructured physiological environments but remains challenging. In this article, we propose a novel direction-speed decoupled control strategy autonomous of microrollers. A modified kinematic model based on extended high-order states proposed capture the dynamic characteristics...