A5042661840- Mycobacterium research and diagnosis
- Melanoma and MAPK Pathways
- Tuberculosis Research and Epidemiology
- Advanced Algorithms and Applications
- Antibiotic Resistance in Bacteria
- Advanced Computational Techniques and Applications
- Infectious Diseases and Tuberculosis
- Structural Engineering and Vibration Analysis
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Advanced Sensor and Control Systems
- Advanced Sensor and Energy Harvesting Materials
- Caching and Content Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Peer-to-Peer Network Technologies
- Geotechnical Engineering and Analysis
- CRISPR and Genetic Engineering
- Civil and Geotechnical Engineering Research
- Web Data Mining and Analysis
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
Tongji University
2013-2024
Shanghai Pulmonary Hospital
2017-2024
Institute of High Performance Computing
2023-2024
Agency for Science, Technology and Research
2024
Nanjing University of Chinese Medicine
2024
Shanxi Agricultural University
2023
Shandong University of Science and Technology
2023
Central South University
2023
Zhengzhou University
2021
Zhengzhou University of Light Industry
2021
Significance Our study provided a comprehensive view of the transcriptional landscape across cell cycle. We revealed lag between transcription and steady-state RNA expression at cell-cycle level characterized large amount active during early mitosis. In addition, our analysis identified thousands enhancer RNAs related factors that are highly correlated with cell-cycle–regulated but not expression, thus highlighting importance epigenetic dynamics progression.
Ulcerative colitis (UC) is a non-specific chronic inflammatory disease with lesions located in the colon and rectum. The aim of this study was to evaluate anti-inflammatory effects exopolysaccharide-1 (EPS-1) isolated by L. helveticus KLDS1.8701 on UC. EPS-1 were studied using dextran sulphate sodium (DSS)-induced UC model. In vivo results showed that administration significantly ameliorated weight loss, shortening, activity index (DAI) score, myeloperoxidase (MPO) activity, tissue damage....
Abstract Advances in computer technologies have enabled scientists to explore research issues their respective domains at scales greater and finer than ever before. The availability of efficient data collection analysis tools presents researchers with vast opportunities process heterogeneous within a distributed environment. To support the by massive computation, suitable scientific workflow system is needed help users manage programs, design reusable procedures experimental tasks. In this...
Endometrial cancer had a relatively high prevalence of MMR deficiency. MMR-D/MSI-H endometrial patients are suggested to be potential beneficiaries PD-1/PD-L1 inhibitor therapy. Here, we explored the prognostic value MSI subtype in and its correlation with immune environment. Based on expression clinical data 78 POLE, 123 299 Other EC samples from TCGA-UCEC project, found that tumors were identified more often early stage, lower age, better patient survival, enriched CD8+ T cells, regulatory...
Objective: To investigate the drug resistance characteristics of Mycobacterium tuberculosis (MTB) isolates from patients with to twelve antituberculous drugs in China. Methods: All clinical MTB were isolated Shanghai Pulmonary Hospital (SPH) during period January 1st December 31th, 2018. Drug susceptibility testing (DST) was performed micro plates 12 accordance relevant guideline. Demographic information, including sex, age and treatment history recorded. Results: A total 1950 included this...
Mycobacterium abscessus complex (MABC) is a group of important infectious agents that are highly associated with drug resistance, and antibiotic treatment usually ineffective. This study investigated the characteristics antimicrobial susceptibility MABC isolates synergy between certain β-lactam combinations against infection.We collected 129 from patients lower respiratory tract infections categorized them into three subspecies. The minimum inhibitory concentrations (MICs) 15 antimicrobials...
Chemokine-induced polarization of lymphocytes involves the rapid collapse vimentin intermediate filaments (IFs) into an aggregate within uropod. Little is known about interactions lymphocyte with other cytoskeletal elements. We demonstrate that human peripheral blood T express plectin, IF-binding, cross-linking protein. Plectin associates a complex structural proteins including vimentin, actin, fodrin, moesin, and lamin B in resting lymphocytes. During chemokine-induced polarization, plectin...
Abstract BRAF is a serine/threonine kinase that harbors activating mutations in ∼7% of human malignancies and ∼60% melanomas. Despite initial clinical responses to inhibitors, patients frequently develop drug resistance. To identify candidate therapeutic targets for inhibitor resistant melanoma, we conduct CRISPR screens melanoma cells harboring an mutation had also acquired resistance inhibitors. investigate the mechanisms pathways enabling inhibitors melanomas, integrate expression,...
An individual tumor harbors multiple molecular alterations that promote cell proliferation and prevent apoptosis differentiation. Drugs target specific have been introduced into personalized cancer medicine, but their effects can be modulated by the activities of other genes or molecules. Previous studies aiming to identify for combination therapies are limited available data. Given recent large scale pharmacogenomic data, it is possible systematically biomarkers contribute jointly drug...
Background: As a dedifferentiated tumor, small cell endometrial neuroendocrine tumors (NETs) are rare and frequently diagnosed at an advanced stage with poor prognosis. Current treatment recommendations often extrapolated from histologically similar in other sites or based on retrospective studies. The exploration for diagnostic therapeutic markers NETs is of great significance. Methods: In this study, we conducted single-cell RNA sequencing specimen obtained patient carcinoma (SCNEC)...
Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the challenge is shift from pathway-centric therapies. Pathway-centric perspectives, which underscore need understand key and their critical properties, could address complexity cancer better than approaches aid drug discovery therapy.We used large-scale...