A5101911941- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Parasitic Infections and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Reproductive System and Pregnancy
- Natural Compound Pharmacology Studies
- Phytoplasmas and Hemiptera pathogens
- Plant and Fungal Interactions Research
- Respiratory viral infections research
- Traditional Chinese Medicine Analysis
- Milk Quality and Mastitis in Dairy Cows
- RNA Research and Splicing
- Plant pathogens and resistance mechanisms
- Cancer, Hypoxia, and Metabolism
St. Jude Children's Research Hospital
2022-2025
Yonsei University
2024-2025
Peking University
2024-2025
China University of Petroleum, East China
2015-2025
Second Military Medical University
2021-2025
Eastern Hepatobiliary Surgery Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2022-2024
Nanjing Forestry University
2024
First Hospital of Shanxi Medical University
2024
The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. consistent, decades-long persistence T . human hosts arises at least part from remarkable level genetic diversity multiple families genes encoding primary target antigens anti-parasite responses. However, highly repetitive nature genome–largely a result these same extensive genes–have prevented...
Cryptosporidiosis is a leading cause of waterborne diarrheal disease globally and an important contributor to mortality in infants the immunosuppressed. Despite its importance, Cryptosporidium community has only had access good, but incomplete, parvum IOWA reference genome sequence. Incomplete sequences hamper annotation, experimental design, interpretation. We have generated new C. assembly supported by Pacific Biosciences (PacBio) Oxford Nanopore long-read technologies comparative...
Programmed death receptor-1 (PD-1) inhibitors have been approved as second-line treatment regimen in hepatocellular carcinoma (HCC), but it is still worth studying whether patients can benefit from PD-1 first-line drugs combined with targeted and locoregional therapy.To estimate the clinical outcome of transarterial chemoembolization (TACE) lenvatinib plus for unresectable HCC (uHCC).We carried out retrospective research 65 uHCC who were treated at Peking Union Medical College Hospital...
Animal experiments indicate that repeated exposure to ketamine adversely affects the developing brain. Whether it has same effect on infants remains unclear. We recruited who were scheduled for 1 3 outpatient laser surgery treatments of benign facial growths with anesthesia. Patients assigned Ket(1), Ket(2), or Ket(3) group, according number treatments. The Bayley Scales Infant Development-Second Edition (BSID-II) was used assess neurodevelopmental outcomes before first and after last...
As a hallmark of chronic kidney disease (CKD), arterial stiffening is related to increased vascular inflammation and cardiovascular morbidity, whereas the underlying mechanism unclear. The study demonstrates that stiffness precedes onset inflammation, matrix stimulates transdifferentiation smooth muscle cells (VSMCs) an inflammatory phenotype via activating Runx2-NLRP3 signaling, which provides novel insights into CKD-related disorder treatment.
Abstract Once considered rare in eukaryotes, polycistronic mRNA expression has been identified kinetoplastids and, more recently, green algae, red and certain fungi. This study provides comprehensive evidence supporting the existence of apicomplexan parasite Cryptosporidium parvum . Leveraging long-read RNA-seq data from different strains using multiple technologies, we demonstrate defined transcripts containing 2-4 protein encoding genes, several validated with RT-PCR. Some polycistrons...
Abstract Cephalopods such as squids, octopuses, and cuttlefishes can change their bodies’ color to match the surrounding environments by contracting or expanding sac just below surface of skin. Inspired this mechanism, artificial cephalopod chromatophores which are prepared thermoresponsive poly( N ‐isopropyl acrylamide)‐based hydrogel films embedded with black, red, yellow pigments presented, they swell shrink under temperature stimuli, like natural chromatophores. The cuttlefish ink...
Abstract Background A key challenge in the medical field is managing gallbladder polyps (GBP) > 10 mm, especially when their nature uncertain. GBP with a diameter exceeding mm are associated an increased risk of cancer, making to management differentiation between benign and malignant types. The current practice, due inability predict accurately, leads excessive surgeries ineffective follow-ups, increasing patient risks burdens. Purpose This study aims establish imaging radiomics model...
// Fei-Zhou Jiang 1,* , Yin-Yan He Hui-Hui Wang 2 Hui-Lin Zhang 1 Jian Xiao-Fang Yan Xiao-Jun Qi Che Jie-Qi Ke Zheng Chen Huan Tong Yong-Li Fang-Yuan Yi-Ran Li and Xiao-Ping Wan 1,3 Department of Obstetrics Gynecology, Shanghai General Hospital, Jiao University School Medicine, Shanghai, China Jiaotong University Affiliated International Peace Maternity & Child Health Hospital the Welfare Institute, 3 First Infant Tongji School * These authors have contributed equally to this work...
Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis.Melatonin its receptors are expressed human granulosa cells, have been shown to influence basal P4 production.However, previous studies addressing regulation of StAR expression by melatonin impact on secretion yielded contradictory results.Here, we demonstrate that upregulates primary cultures granulosa-lutein (hGL) cells obtained from women undergoing...
Cryptosporidium is a protist parasite that has been identified as the second leading cause of moderate to severe diarrhea in children younger than two and significant mortality worldwide. complex, obligate, intracellular but extra cytoplasmic lifecycle single host. How genes are regulated this remains largely unknown. Long non-coding RNAs (lncRNAs) play critical regulatory roles, including gene expression across broad range organisms. lncRNAs have reported enter host cell nucleus affect...
In October 2020, highly pathogenic avian influenza A(H5N8) viruses were detected in 2 dead swans Inner Mongolia, China. Genetic analysis showed that the H5N8 isolates belong to clade 2.3.4.4b and cluster with isolated Eurasia fall of 2020.
Clinical reports of multiple primary malignant tumors (MPMTs) in the digestive system are increasing. In China, although survival rate patients with MPMTs is increasing, quality life very low. Many have reached advanced stage when second tumor found, resulting no early intervention and treatment. This due to misunderstanding by clinicians, who treat such as metastases. Therefore, before a patient has tumor, doctors should understand some common combinations provide clinical guidance...