A5100452939- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- MicroRNA in disease regulation
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Cancer survivorship and care
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
Nanjing University of Chinese Medicine
2021-2025
Shaanxi Provincial People's Hospital
2016-2025
Research Center Borstel - Leibniz Lung Center
2024-2025
First Hospital of Jilin University
2024
Lanzhou University
2017-2024
Lanzhou University Second Hospital
2017-2024
Jiangsu Province Hospital
2014-2024
PharmacoGenetics (China)
2024
Chongqing Medical University
2016-2024
Shandong Provincial Hospital
2015-2024
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based genome-wide CRISPR screens a data-mining approach to identify drugs that can upregulate without inducing PD-L1. screening identified TRAF3, suppressor of the NFκB pathway, as negative regulator not The Traf3-knockout gene signature is associated better survival in ICB-naïve and ICB response. We then screened for similar...
In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC) and well-matched liver metastatic CRC using single-cell spatial transcriptome RNA sequencing. We generated 41,892 CD45 − nonimmune cells 196,473 + immune from 27 samples six patients, found that CD8_CXCL13 CD4_CXCL13 subsets increased significantly in exhibited high proliferation ability tumor-activating characterization, contributing to better prognosis patients. Distinct fibroblast profiles were...
Purinergic 2X7 receptor (P2X7R) and nucleotide‑binding oligomerization domain-like protein 3 (NLRP3) are expressed in macrophages atherosclerotic lesions. However, the mechanisms through which P2X7R participates inflammatory response atherosclerosis remain largely unknown. The aim of present study was to investigate role action NLRP3 inflammasome following stimulation with oxidized low-density lipoprotein (oxLDL). We observed expression distribution plaque coronary arteries from an autopsy...
Abstract Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical strains. They widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional immune system. Large volumes syngeneic expression profiles under different treatments have been generated, although lack systematic collection analysis makes data reuse challenging. We present Tumor Immune MOuse (TISMO), database with an extensive model...
Abstract The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) primed (EpiSCs), respectively. However, these two states may not sufficient to reflect the full complexity developmental potency during development. Here we report establishment self-renewing formative pluripotent (fPSCs) which manifest features poised for gastrulation. fPSCs can established from different mouse ESCs, pre-/early-gastrula epiblasts induced PSCs. Similar...
Rationale: Previous studies have suggested that myocardial inflammation plays a critical role after ischemic infarction (MI); however, the underlying mechanisms still need to be fully elucidated. WW domain-containing ubiquitin E3 ligase 1 (WWP1) is considered as an important therapeutic target for cardiovascular diseases due its crucial function in non-ischemic cardiomyopathy, though it remains unknown whether targeting WWP1 can alleviate and injury post-MI. Methods: Recombinant...
Environmental benzo(a)pyrene (BaP) and its ultimate metabolite BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide) are universal inevitable persistent organic pollutants endocrine disrupting chemicals. Angiogenesis in placental decidua plays a pivotal role healthy pregnancy. Ferroptosis is newly identified iron-dependent cell death mode. However, till now, BaP/BPDE exposure, ferroptosis, defective angiogenesis, miscarriage have never been correlated; their regulatory mechanisms rarely...
Colorectal cancer (CRC) represents the third most common in males and second females worldwide. Here, we performed a quantitative 8-plex iTRAQ proteomics analysis of secreted proteins from five colonic fibroblast cultures three colon epithelial cell lines. We identified 1114 at 0% FDR, including 587 potential proteins. further recognized 116 fibroblast-enriched which were significantly associated with movement, angiogenesis, proliferation wound healing, 44 cell-enriched By interrogation...
Recent preclinical studies revealed the efficacy of combined use PI3K inhibitor BKM120 and PARP Olaparib in breast prostate cancers. The current study investigated effect such drug combination on ovarian cancer. Here we showed that inhibition effectively synergized to inhibit proliferation, survival invasion majority cancer cell lines harboring PIK3CA mutations, including SKOV3, HEYA8, IGROV1. Mechanistically, treatment inhibitors resulted an exacerbated DNA damage response more...
Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node previously unappreciated negative feedback loop that limits efficacy of current ER-targeted therapies. Estrogen directly drives CSK expression ER+ cancer. At low levels, is case patients with cancer resistant to endocrine and poorest outcomes, p21 protein-activated 2...
Highlights•mTORC1 is a potent regulator of white to beige adipogenesis•mTORC1 inhibition leads WAT browning and occurs despite sympathetic denervation•COX-2 prostaglandins are essential for in Raptor-deficient mice•mTORC1 suppresses COX-2/PG pathway via CRTC2-dependent mechanismSummaryBeige adipocytes present adipose tissue (WAT) have thermogenic capacity orchestrate substantial energy metabolism counteract obesity. However, adipocyte-derived signals that act on progenitor cells control...
Background Immune checkpoint blockade (ICB) response in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is limited to 15%–20% of patients underpinnings resistance remain undefined. Methods Starting with an anti-PD1 sensitive murine HNSCC line, we generated isogenic resistant model. Mass cytometry was used delineate tumor microenvironments both parental oral (MOC1) MOC1esc1 tumors. To examine heterogeneity clonal dynamics infiltrating lymphocytes (TILs), applied paired...
Autism spectrum disorder (ASD) is a neurodevelopmental disease featuring social interaction deficits and repetitive/stereotyped behaviours; the prevalence of this has continuously increased. Progranulin (PGRN) neurotrophic factor that promotes neuronal survival differentiation. However, there have not been sufficient studies investigating its effect in animal models autism. This study investigated effects PGRN on autistic phenotypes rats treated with valproic acid (VPA) assessed underlying...
Abstract Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell–specific regulators simultaneously modulate tumor immunity and another oncogenic pathway then used it identify 38 candidate immune–metabolic regulators. We show activities of these stratify patients with melanoma by their response anti–PD-1 using machine learning deep neural approaches, which...
Abstract Human trophoblast cells are crucial for healthy pregnancy. However, whether the defective homologous recombination (HR) repair of dsDNA break (DSB) in may induce miscarriage is completely unknown. Moreover, abundance BRCA1 (a protein HR repair), its recruitment to DSB foci, and epigenetic regulatory mechanisms, also fully unexplored. In this work, it identified that a novel lnc‐HZ10, which highly experssed villous tissues recurrent (RM) vs their control group, suppresses cell....
Ester-functionalized anionic surface-active ionic liquids (SAILs), 3-methyl-1-(ethoxycarbonylmethyl)imidazolium dodecylsulfate ([C1COOC2C1im][C12SO4]) and 3-methyl-1-(ethoxycarbonylmethyl)pyrrolidinium ([C1COOC2C1Py][C12SO4]), were synthesized. The tensiometric profiles demonstrate that, in pure water, the studied SAILs exhibit higher surface activity than traditional surfactant, sodium dodecyl sulfate (SDS), cationic SAILs, 1-dodecyl-3-methylimidazolium bromide ([C12mim]Br)...
Myocardial fibrosis is a characteristic feature of cardiomyopathies. However, no effective strategies to attenuate cardiac are currently available. Late-stage endothelial progenitor cells (EPCs) precursors (ECs) that repair the heart through paracrine mechanism. In present study, we tested whether EPC-derived exosomes regulate differentiation fibroblasts into ECs. We isolated late-stage EPCs from human peripheral blood (PB) and used immunofluorescence flow cytometry confirm their identity....
The tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) was frequently mutated in cancers. modulation mechanism of ARID1A for PI3K/AKT signaling gastric cancer (GC) remains elusive. Here, we found that depletion endogenous enhanced the vitro proliferation, colony formation, cellular growth, nutrient uptake and vivo xenograft growth GC cells. activation by ARID1A-silencing profiled using a phospho-protein antibody array. phosphorylation PDK1, AKT, GSK3β 70S6K, mRNA...
Saikosaponins-a (Ssa) is a major bioactive extract of Radix Bupleuri which traditional Chinese medicine. The roles inflammatory response and lipid transportation in the process atherosclerosis have drawn increasing attention. We explored regulation immune-inflammatory role Ssa early atherosclerosis. antiatherogenic actions possible molecular mechanisms were texted THP-1 cells. examined effect on oxidized low-density lipoprotein (ox-LDL)-induced uptake, cholesterol efflux, response....