A5102004890- Pulmonary Hypertension Research and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Breast Cancer Therapies
- Tryptophan and brain disorders
- Cystic Fibrosis Research Advances
- Renal cell carcinoma treatment
- Renin-Angiotensin System Studies
- Drug Transport and Resistance Mechanisms
- Invertebrate Taxonomy and Ecology
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Parasites and Host Interactions
- Rice Cultivation and Yield Improvement
- Neuroscience and Neuropharmacology Research
- FOXO transcription factor regulation
- Animal Ecology and Behavior Studies
- Epigenetics and DNA Methylation
- Agricultural Systems and Practices
- Influenza Virus Research Studies
- Renal and related cancers
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
Ningbo University
2014-2024
Background: Epidemiologic studies and animal model experiments have shown that parasites significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of Schistosoma japonicum (S.japonicum) produced by Escherichia coli (E. coli), has been to immunoregulatory in vivo vitro. In this study, we aimed determine the rSj16 dextran sulfate sodium (DSS)-induced colitis. Methods: DSS-induced colitis mice were...
Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node previously unappreciated negative feedback loop that limits efficacy of current ER-targeted therapies. Estrogen directly drives CSK expression ER+ cancer. At low levels, is case patients with cancer resistant to endocrine and poorest outcomes, p21 protein-activated 2...
Endothelial autocrine signaling is essential to maintain vascular homeostasis. There limited information about the role of endothelial in regulating severe pulmonary remodeling during onset arterial hypertension (PAH). In this study, we employed first (PH) mouse model, Egln1Tie2Cre (Tie2Cre-mediated disruption Egln1) mice, identify novel mediating cell (PVEC) proliferation and pathogenesis PAH. PVECs isolated from lung expressed upregulation many growth factors or angiocrine such as CXCL12,...
Abstract Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis , exhibits natural anti-schistosome characteristics. The mechanisms of susceptibility remain poorly understood. Comparison schistosome infection M. with laboratory mice (highly sensitive infection) offers a good model system investigate these and gain an insight into...
The aim of our study was to evaluate the relationship between four CFTR variations and congenital bilateral absence vas deferens (CBAVD). A systematic search performed in literature databases for case–control studies with risk CBAVD. total 29 among 1139 controls 1562 CBAVD patients were gathered meta-analyses three commonly tecsted (5T, ΔF508 M470V) Our observed significant associations all variations, including 5T (P < 0.001, OR = 8.35, 95% CI 6.68-10.43), M470V 0.027, 0.74, 0.60-0.91)...
Effective biomarkers and models are needed to improve the prognostic prospects of clear cell renal carcinoma (ccRCC). The purpose this work was identify DNA methylation evaluate utility analysis for ccRCC prognosis. An overview genome-wide tissues derived from Cancer Genome Atlas (TCGA) database download analysis. signatures were identified using Cox regression methods. potential clinical significance acting as a novel markers analyzed Kaplan-Meier method receiver operating characteristic...
Endothelial autocrine signaling is essential to maintain vascular hemostasis. There limited in-formation about the role of endothelial in regulating severe pulmonary vas-cular remodeling during onset arterial hypertension (PAH). In this study, we employed first PAH mouse model, Egln1Tie2Cre (Tie2Cre-mediated disruption Egln1) mice, identify novel mediating cells (PVECs) hyperproliferation and pathogenesis PAH. PVECs isolated from lung expressed upregulation many growth factors or angiocrine...
Endothelial autocrine signaling is essential to maintain vascular hemostasis. There limited in-formation about the role of endothelial in regulating severe pulmonary vas-cular remodeling during onset arterial hypertension (PAH). In this study, we employed first PAH mouse model, Egln1Tie2Cre (Tie2Cre-mediated disruption Egln1) mice, identify novel mediating cells (PVECs) hyperproliferation and pathogenesis PAH. PVECs isolated from lung expressed upregulation many growth factors or angiocrine...
Recently, along with the development of biochemical and molecular immunological techniques, diagnosis methods have been improved in which preparing natural parasite antigens, genetically engineered recombinant antigens applied by using agglutination test, complement fixation to detect human's serum antibodies for identification paragonimus infections.To improve detection rate, some scholars used phage peptide library technology further diagnostic effect on Paragonimus westermani humans.In...