A5100397132- Estrogen and related hormone effects
- Genetic Mapping and Diversity in Plants and Animals
- Odor and Emission Control Technologies
- Reproductive System and Pregnancy
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Genetic Associations and Epidemiology
- Genetic and Kidney Cyst Diseases
- Mathematical and Theoretical Epidemiology and Ecology Models
- High Altitude and Hypoxia
- 14-3-3 protein interactions
- Growth Hormone and Insulin-like Growth Factors
- Immune responses and vaccinations
- Congenital gastrointestinal and neural anomalies
- Chromatin Remodeling and Cancer
- Organ and Tissue Transplantation Research
- Lipid metabolism and disorders
- Effects of Environmental Stressors on Livestock
Huazhong Agricultural University
2008-2023
Sun Yat-sen University
2023
Yuhuangding Hospital
2023
Third Affiliated Hospital of Sun Yat-sen University
2023
Pulmonary Hospital of Lanzhou
2023
First Hospital of Jilin University
2023
Jilin University
2023
Xiangnan University
2021
University of California, San Diego
2021
Affiliated Hospital of North Sichuan Medical College
2020
Implantation and placentation are critical steps for successful pregnancy. The pig has a non-invasive placenta the uterine luminal epithelium is intact throughout To better understand regulation mechanisms in functions of endometrium at three certain gestational stages that embryo/fetal loss pigs, we characterized microRNA (miRNA) expression profiles on days 15 (implantation period), 26 (placentation period) 50 (mid-gestation gestation. differentially expressed miRNAs across were detected...
Piglet birth weight variability, a trait also known as the within-litter homogeneity of weight, reflects sow's prolificacy, because it is positively genetically correlated with preweaning mortality but negatively mean growth piglets during sucking. In addition, maternal additive genetic variance and heritability has been found exist for this trait, thus, reduction in variability piglet to improve sow prolificacy possible by selective breeding. We performed genome wide association study...
Ammonia toxicity to respiratory system in pig faming is of particular concern, but the molecular mechanism remains still unclear. The present study was devoted assess impacts ammonia exposure on lung tissues based a using 80 ppm exposing piglets for different days. histology analysis revealed induced injury and inflammatory response, as indicated by epithelial-mesenchymal transition (EMT), significant thickening alveolar septa, infiltration cells excessive mucus production. transcriptome...
Ammonia, a common toxic gas, is not only one of the main causes haze, but also can enter respiratory tract and directly affect health humans animals. Pig was used as an animal model for exploring molecular mechanism dose effect ammonia toxicity to lung. In this study, apoptosis type II alveolar epithelial cells observed in high exposure group using transmission electron microscopy. Gene protein expression analysis transcriptome sequencing western blot showed that low induced T-cell-involved...
The causal effects of smoking and alcohol use on the risk infectious diseases are unclear, it is hard investigate them in an observational study due to potential confounding factors. aim this was Mendelian randomization (MR) techniques assess causalities between smoking, diseases.Univariable multivariable MR analyses were performed using genome-wide association data for age initiation regular (AgeSmk, N = 341,427), (SmkInit, 1,232,091), cigarettes per day (CigDay, 337,334), lifetime (LifSmk,...
The development of the microscopically folded structure diffuse epitheliochorial placenta in pigs is important because it expands surface area for maternal-fetal exchange, resulting an increase placental efficiency. To better understand regulatory mechanisms involved this process, we characterized miRNA expression profiles porcine placentas during initiation and establishment fold development. A total 42 miRNAs were found to be differentially expressed, their putative target genes predicted...
Miliary tubersculosis (TB), an acute systemic blood disseminated tuberculosis mainly caused by Mycobacterium ( M. ), can cause signs of lymphopenia in clinical patients. To investigate whether/how persistent mycobacteria antigen stimulation impairs hematopoiesis and the therapeutic effect interleukin-7 (IL-7), a mouse model Bovis Bacillus Calmette-Guérin (BCG) intravenous infection with/without additional with multi-antigen cocktail containing ESAT6-CFP10 (EC) Mtb10.4-HspX (MH) was...
Summary Aim Differentiated embryonic chondrocyte gene 1 ( DEC 1) is involved in the neuronal differentiation and development. The aim of this study to investigate role 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine MPP + )‐induced PD model. Methods location tyrosine hydroxylase TH )‐positive neurons were detected by immunofluorescence. MPTP mouse subacute model was established evaluate change expression midbrain. Then, SH ‐ SY 5Y cells used ‐induced neurotoxicity. Results We showed that...
As one of the main environmental stressors commonly found in closed pig houses, ammonia poses high risks to well-being humans and animals. This study is aimed at assessing toxicity exposure (80 ppm for 12 days) on nasal mucosa piglets. Firstly, we that after exposure, number white blood cells significantly increased serum levels cytokine IL-4 were decreased. Then, histological analyses showed significant thickening excessive mucus production group. Finally, RNA-seq demonstrated disturbed...
Abstract Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis , exhibits natural anti-schistosome characteristics. The mechanisms of susceptibility remain poorly understood. Comparison schistosome infection M. with laboratory mice (highly sensitive infection) offers a good model system investigate these and gain an insight into...
<b><i>Objective:</i></b> Estrogen receptor-α36 (ER-α36), a newly identified variant of ER-α, is predominantly membrane-based and mainly mediates nongenomic estrogen signaling. In this study, we investigated the expression ER-α36 in human endometrial carcinoma tissues to understand relationship between its clinicopathological characteristics. <b><i>Methods:</i></b> was assessed by immunostaining 73 carcinomas, 20 normal tissues, 9 with atypical...
Ammonia is one of the major environmental pollutants in pig industry that seriously affects airway health pigs. In this study, we aimed to investigate metabolic profiling changes piglets' lung tissue after exposure 0 ppm (CG), 20 (LG) and 50 (HG) ammonia for 30 days. Compared with control group, obvious lesions were observed HG, including interstitial thickening, inflammatory cell infiltration focal hemorrhage. The significantly increased content malondialdehyde combined decreased mRNA...
Aim: Ammonia is a toxic gas that not only causes environmental pollution, but also harmful to human health after inhalation. Liver an important detoxification organ can convert external or metabolized substances into nontoxic substances. However, the effects of ammonia exposure on livers have been well studied.Method: In this study, pigs were used as animal model and exposed 80 ppm (8 h during 12 days), then, RNA-seq conducted explore key genes in response high livers.Result: Gene set...
Abstract Introduction Rubinstein‐Taybi syndrome (RSTS) is a rare genetic caused primarily by mutation in the CREBBP gene found on chromosome 16. Patients with RSTS are at greater risk for variety of medical problems, including upper airway obstruction and aspiration. Childhood interstitial lung disease (ILD) thus far has not been definitively linked to RSTS. Here we present three patients who developed ILD discuss possible mechanisms which may be involved development ILD. Methods Routine...
Abstract A bacteriophage (in short, phage) is a virus that can infect and replicate within bacteria. Assuming uninfected infected bacteria are capable of reproducing with logistic law, we investigate model infection resembles simple SI-models widely used in epidemiology. The dynamics host-parasite co-extinctions may exhibit four scenarios: hosts parasites go extinct, coexist. By using the Jacobian matrix Bendixson–Dulac theory, local global stability analysis steady states provided; basic...
To investigate the influence of storage time and temperature on plasma insulin levels to establish a correction formula.Venous blood samples were taken from 20 volunteers processed as follows: whole samples, centrifuged separated stored at 4°C or 25°C. Insulin determined by direct chemiluminescence 0, 0.5, 1, 2, 4, 8 hours. According correlation between concentration ratio time, formulas for established. verify test, venous another 33 in same way. The corrected after 3, 6, 12, 24 hours...