A5100717285- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Molecular Biology Techniques and Applications
- Effects of Environmental Stressors on Livestock
- Breast Cancer Treatment Studies
- Regulation of Appetite and Obesity
- Agriculture, Soil, Plant Science
- Adipose Tissue and Metabolism
- Animal Behavior and Welfare Studies
- RNA Research and Splicing
- Gene expression and cancer classification
- Breast Lesions and Carcinomas
- MRI in cancer diagnosis
- 3D IC and TSV technologies
- Cancer, Hypoxia, and Metabolism
- Biochemical Analysis and Sensing Techniques
- Polyamine Metabolism and Applications
- Neurological diseases and metabolism
- Connective tissue disorders research
- Hearing, Cochlea, Tinnitus, Genetics
- Diverse Topics in Contemporary Research
- Economics of Agriculture and Food Markets
- Cerebrovascular and genetic disorders
Gachon University Gil Medical Center
2025
National Institute of Animal Science
2008-2022
Chungnam National University
2020
Gyeongsang National University
2018
Kyungpook National University Medical Center
2018
Kyungpook National University Hospital
2018
Rural Development Administration
2003-2017
Sunchon National University
2017
Korea University Medical Center
2017
Samsung (South Korea)
2006-2012
Purpose To determine the prognostic value of peritumoral edema identified at preoperative breast magnetic resonance (MR) imaging for disease recurrence in patients with invasive cancer. Materials and Methods Between January 2011 December 2012, 353 women (median age, 49 years; range, 27–77 years) cancer who had undergone MR mastectomy or breast-conserving surgery were identified. Two radiologists independently reviewed on basis degree signal intensity surrounding tumor T2-weighted images. The...
Animal domestication involved drastic phenotypic changes driven by strong artificial selection and also resulted in new populations of breeds, established humans. This study aims to identify genes that show evidence recent during pig domestication.Whole-genome resequencing 30 individual pigs from domesticated Landrace Yorkshire, 10 Asian wild boars at ~16-fold coverage was performed resulting over 4.3 million SNPs for 19,990 genes. We constructed a comprehensive genome map directional...
Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic factors common form of obesity, we conducted local genomic de novo sequencing, 18.2 Mb, porcine QTL region affecting fatness traits, carried out SNP association studies backfat thickness intramuscular fat content pigs. In order relate human...
This is the first study reporting on incidence and clinical aspects of sudden sensorineural hearing loss (SSNHL) in South Korea. Using Health Insurance Review Assessment Service data from 2011 to 2015, monthly unilateral SSNHL according patients’ sex, age, month diagnosis were investigated. The increased over 5-year period, with a mean annual 17.76 cases/ 100,000 population. most patients presenting their 60s. There was slight female preponderance, male-to-female ratio 1: 1.35. Most new...
Purpose:To analyze the frequency, and clinical characteristics of ocular injuries in patients with prior blow-out fractures who experience new blunt trauma, to assess whether old orbital provide a protective effect against subsequent trauma. Methods:The medical records 1,315 trauma were reviewed.A total 927 had or facial CT scans ophthalmologist evaluations considered.After applying exclusion criteria, 568 581 affected eyes included final analysis.The divided into two groups based on...
Synopsis Rosmarinic acid (RA) has a number of interesting biological activities, e.g. anti‐viral, anti‐bacterial, anti‐inflammatory and antioxidant. The antioxidant activity RA is stronger than that vitamin E. Despite its strong activity, it was limited to use in cosmetics because the low water solubility, discolouration chemical instability. purpose this study prepare RA‐loaded polycaprolactone (PCL) microspheres using emulsion solvent evaporation method characterize them with different...
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) infection is the most important viral disease causing severe economic losses in swine industry. However, mechanisms underlying gene expression control immunity-responsible tissues at different time points during PRRSV are poorly understood. We constructed an integrated co-expression network identified tissue- time-dependent biological of through bioinformatics analysis using three (lungs, bronchial lymph nodes [BLNs],...
Abstract Indigenous Korean breeds such as Hanwoo (Korean) cattle have adapted to their local environment during the past 5000 years. In 1980s, National Genetic Improvement Program was established develop a modern economic breed for beef production in Korea through artificial selection. This process is thought altered genomic structure of breeding traits over time. The detection genetic variants under selection could help elucidate mechanism breeds. response natural and 40-year program. We...
A porcine genomic bacterial artificial chromosome (BAC) library was constructed by cloning partial EcoRI-digested high-molecular-weight DNA from a Korean native boar into the EcoRI site of pBACe3.6 vector. The consists about 165,000 clones with an average insert size 125 kb, representing seven genome equivalents coverage. About 130,000 (corresponding to fivefold coverage) were arrayed in 14 superpools which organized as four dimensional pools. further characterized PCR screening 38...
Summary We measured and compared the transcripts of adipose tissue from Korean native pig (KNP) Yorkshire (YS) breeds to investigate breed‐specific transcription changes. employed both Affymetrix porcine genome array quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). found eight genes showing significant changes between two breeds. Based on a literature review, these were indicative differences in extracellular structure density potential metabolize xenobiotic chemicals...
Objective This study was conducted to estimate breed-specific variance components for total number born (TNB), alive (NBA) and mortality rate from birth through weaning including stillbirths (MORT) of three main swine breeds in Korea. In addition, the importance maternal genetic service sire effects estimation models evaluated. Methods Records farrowing traits 6,412 Duroc, 18,020 Landrace, 54,254 Yorkshire sows collected January 2001 September 2016 different farms Korea were used analysis....
Korean Hanwoo cattle have been subjected to intensive artificial selection over the past four decades improve meat production traits. Another three varieties very closely related reside in Korea (Jeju Black and Brindle) China (Yanbian). These breeds not part of a breeding scheme Here, we compare selected against these similar but presumed be unselected populations identify genomic regions that under recent pressure due program. Rsb statistics were used contrast genomes versus pooled sample...
Comprehensive information on genetic diversity and introgression is desirable for the design of rational breed improvement conservation programs. Despite concerns regarding Western pig breeds into gene pool Korean native (KNP), level this admixture has not yet been quantified. In present study, we genotyped 93 animals, representing four KNP, using porcine SNP 60K BeadChip to assess their estimate among breeds. Expected heterozygosity was lowest in Berkshire (0.31) highest Landrace (0.42)....
Abstract We identified a potential molecular marker associated with meat quality traits in the myosin heavy chain 4 , MYH4 gene of Landrace pigs. Sequencing revealed single nucleotide polymorphism (SNP; g.‐1398G>T) 5' upstream region . It was significantly number type IIa muscle fibers and water‐holding capacity based on filter‐paper fluid uptake. The GG genotype groups had greater larger area composed than other group ( P = 0.004 0.061, respectively). Expression level TT or GT higher...
We assessed the effects of single-nucleotide polymorphisms (SNPs) within porcine fatty acid synthase (FASN) gene regarding meat quality and composition in two pig populations: Korean native pigs (KNP) were crossed with Yorkshire (YS) <TEX>$F_2$</TEX>, KNP Landrace (LR) <TEX>$F_2$</TEX>. Direct DNA sequencing using eight YS revealed SNPs: c.265C>T (silent) exon 4 c.6545A>C (Asn<TEX>${\rightarrow}$</TEX>His) 39. The frequency SNPs was analyzed polymerase chain reaction-restriction fragment...
Board level drop reliability of MSP (multi stack package) composed a logic chipset package at bottom and an MCP chip top was investigated. The the tested by developed (shock) tester. Applied shock half sine shape with 1500 G peak acceleration 0.5 msec duration time. Failures were detected four daisy chain loops going through solder balls traces on each package. All failures observed ball. locations failed dye pry technology. detailed physics failure cross sectioning. EDX analysis carried out...
Objective The study was designed to perform a genome-wide association (GWA) and partitioning of genome using Illumina's PorcineSNP60 Beadchip in order identify variants determine the explained heritability for total number teats Yorkshire pig. Methods After screening with following criteria: minor allele frequency, MAF≤0.01; Hardy-Weinberg equilibrium, HWE≤0.000001, pair-wise genomic relationship matrix produced 42,953 single nucleotide polymorphisms (SNPs). A mixed linear model-based...
4개의 후보 유전자를 분석해본 결과, 돼지의 주요 염색체 부위 및 유전자들이 경제성 요인들과 관계가 있는 것으로 확인됐다. 양돈업계에서 DNA 기술을 이용한 정보를 활용하기 위해 본 연구에서는 유전자에서 생성된 중합효소연쇄반응(PCR) 생성물을 비교 재 서열 함으로써 단일염기변이(SNP) 표지들을 개발했다. 또한 이들 SNP에 대해 PCR 제한효소 절편길이 다형 성(RFLP)분석을 전개한 후, 이를 대한민국 내 버크셔 종 돼지 개체군의 유전자형을 분석하는데 활용했다. 연구는 유용한 단일염기변이를 식별하고 돼지개체군 경제적으로 중요한 특성들과 SNP의 연관성을 확인하는 데 그 목적이 있다. This study was conducted to identify useful single nucleotide polymorphisms (SNPs) and determine their association with economically important traits in pig...