A5101756589- Kruppel-like factors research
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Renal Diseases and Glomerulopathies
- Peptidase Inhibition and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Gastrointestinal disorders and treatments
- Genetic Syndromes and Imprinting
- Tea Polyphenols and Effects
- Spaceflight effects on biology
- Sirtuins and Resveratrol in Medicine
- Extracellular vesicles in disease
- Meningioma and schwannoma management
- Genetic and Kidney Cyst Diseases
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Nerve Injury and Rehabilitation
Shanghai Sixth People's Hospital
2022-2025
Shanghai Jiao Tong University
2011-2025
Nanjing Medical University
2018-2025
Huadong Hospital
2024
Fudan University
2024
Capital Medical University
2023
Beijing Friendship Hospital
2023
National Natural Science Foundation of China
2023
Roche (China)
2017
Sun Yat-sen University
2016
Rationale: Previous studies have suggested that myocardial inflammation plays a critical role after ischemic infarction (MI); however, the underlying mechanisms still need to be fully elucidated. WW domain-containing ubiquitin E3 ligase 1 (WWP1) is considered as an important therapeutic target for cardiovascular diseases due its crucial function in non-ischemic cardiomyopathy, though it remains unknown whether targeting WWP1 can alleviate and injury post-MI. Methods: Recombinant...
Abstract Background Triglyceride-glucose (TyG) index is an efficient indicator of insulin resistance and proven to be a valuable marker in several cardiovascular diseases. However, the relationship between TyG cardiac arrest (CA) remains unclear. The present study aimed investigate association with occurrence clinical outcomes CA. Methods In this retrospective, multicenter, observational study, critically ill patients, including patients post-CA, were identified from eICU Collaborative...
Abstract Mitochondrial dysfunction is a key factor in exacerbating pressure overload‐induced cardiac hypertrophy and linked to increased morbidity mortality. ECSIT, crucial adaptor for inflammation mitochondrial function, has been reported express multiple transcripts various species tissues, leading distinct protein isoforms with diverse subcellular localizations functions. However, whether an unknown ECSIT isoform exists cells its potential role regulating function pathological remained...
SIRT6 is a member of the sirtuin family class III histone deacetylases. It plays important roles in regulating genomic stability, metabolism, stress response and aging. Our previous study has revealed that attenuates myocardial hypertrophy by inhibiting NF-κB activation, but related molecular mechanisms remain to be clarified. In present study, we showed p300 acetylase was involved protective effect against phenylephrine (PE)-induced cardiomyocyte hypertrophy. cultured neonatal rat...
Cardiac fibrosis is an essential pathological process in pressure overload (PO)-induced heart failure. Recently, myocyte-fibroblast communication proven to be critical failure, which, growth of cardiomyocytes (CMs) may promote via miRNAs-containing exosomes (Exos). Peli1 regulates the activation NF-κB and AP-1, which has been demonstrated engage miRNA transcription cardiomyocytes. Therefore, we hypothesized that CMs cardiac fibroblasts (CFs) through exosomal miRNA-mediated paracrine...
As one of the most common types carcinomas, lung cancer has high incidence and mortality rates. Among pathological cancer, pulmonary adenocarcinoma is prevalent. Advancements in medical treatments have contributed to improved prognosis adenocarcinomas. However, this case report revealed a rare refractory adenocarcinoma, suggesting that further research robust management strategies are needed improve clinical outcomes. In regard, 18F-fluorodeoxyglucose positron emission tomography/ computed...
Interleukin-6 (IL-6) overproduction has been considered to contribute inflammatory damage of glomerular mesangial cells (GMCs) in human proliferative glomerulonephritis (MsPGN) and its rat model called Thy-1 nephritis (Thy-1N). However, the regulatory mechanisms IL-6 expression GMCs upon sublytic C5b-9 timulation remain poorly understood. We found that Krüppel-like factor 4 (KLF4) bound promoter (-618 -126 nt) activated gene transcription. Furthermore, lysine residue 224 KLF4 was acetylated...
Abstract Sublytic C5b-9 formation on glomerular mesangial cells in rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis, is accompanied by the production proinflammatory cytokines, but relationship between sublytic and cytokine synthesis underlying mechanism remains unclear. To explore problems mentioned above, this study, we first examined levels ILs (e.g., IL-23 IL-36a) as well transcription factor (KLF4) coactivator (PCAF) renal tissues Thy-1N rats cell...
Background: Colorectal cancer (CRC) is the third most prevalent in world. Traditional tissue biopsy cannot provide dynamic monitoring of patients' tumors or reflect characteristics real time because sampling process invasive and accompanied by risks. Circulating tumor cells (CTCs) are considered a major cause metastasis, investigating CTCs helps to understand biology vulnerability malignant during hematogenous metastasis. Methods: We sequentially used epithelial cell adhesion molecule...
Rat Thy-1 nephritis (Thy-1N) is an experimental mesangial proliferative glomerulonephritis (MsPGN) for studying human MsPGN.Although sublytic C5b-9 complex formation on glomerular cells (GMCs) and renal MCP-1 RANTES production in rats with Thy-1N have been proved, the role mechanism of or synthesis GMCs induced by are poorly elucidated.In this study, we first found expression transcription factor (KLF6), co-activator (KAT7) chemokines (MCP-1 RANTES) was all up-regulated both tissue (in vivo)...
Colorectal cancer (CRC) is the third most frequent cause of cancer-related death, while tumor/node/metastasis (TNM) stage American Joint Committee on Cancer guideline making treatment strategy and predicting survival. The aim this study to investigate association preoperative 2-deoxy-2[
Sudden internal carotid artery (ICA) occlusive vasospasm is a serious complication of intracranial aneurysm embolization. Conventional spasmolysis with papaverine yields generally poor outcome. We believe that arterial infusion lidocaine may offer better outcome.We retrospectively reviewed the outcome patients treated either or for during embolization.14 undergoing embolization had ICA vasospasm. Among 8 who received conventional treatment improved partially in 5. In 3 cases, was...
Cardiac maladaptive remodeling is one of the leading causes heart failure with highly complicated pathogeneses. The E3 ligase tripartite motif containing 35 (TRIM35) has been identified as a crucial regulator governing cellular growth, immune responses, and metabolism. Nonetheless, role TRIM35 in fibroblasts cardiac remains elusive.
The activation of complement system and the formation C5b-9 complex have been confirmed in glomeruli patients with mesangioproliferative glomerulonephritis (MsPGN). However, role mechanism C5b-9-induced injury glomerular mesangial cell (GMC) are poorly understood. Rat Thy-1N is an animal model for studying MsPGN. It has revealed that attack to GMC rat sublytic, sublytic can cause apoptosis, but underlying not fully elucidated. To explore regulatory MsPGN lesion, we used first detected change...
Objective To investigate the clinical efficacy of L1-S1 selective posterior rhizotomy (SPR) at medullary conus level for treatment double lower extremities spastic cerebral palsy(CP). Methods A total 109 CP children underwent SPR consul were selected in Second Affiliated Hospital Xinjiang Medical University from October 2010 to May 2014.The 4 groups analyzed terms muscle tension and gross motor function limbs 6 months before after operation, retrospectively.The SPSS 17.0 software was...
Baroreflex is critical to maintain the blood pressure homeostasis, and quantification of baroreflex regulation function (BRF) can provide guidance for disease diagnosis, treatment healthcare. Current BRF such as sensitivity cannot represent systematically. From perspective complex systems, we regard that emergence result diverse states interactions in physiological mechanisms. Therefore, three-layer constructed this work, which from mechanisms indexes then BRF. On basis, since entropy...
Abstract 99m Tc-RBC bleeding scan in a 17-year-old adolescent girl showed an increased focal activity the pelvis. However, SPECT/CT that this was located uterus, which considered normal variant considering patient her fourth day of menstrual period. Subsequent TcO 4 − Meckel typical characteristic ectopic gastric mucosa small bowel. Postsurgical pathology confirmed diagnosis mucosa. This case suggested period uterus should be included as differential scan.
Background: The differenzial diagnosis of pancreatic disease is still crucial. Invasive measures which can obtain tissue samples have high specificity. However, contrast-enhanced endoscopic ultrasonography (CE-EUS) may offer a non-invasive option and better visualization.
Objective To provide an objective basis for differential diagnosis of pancreatic diseases through quantitative analysis the different features contrast-enhanced endoscopic ultrasonography （CE-EUS）. Methods A total 32 patients with suspected or confirmed neoplasms chronic pancreatitis and 19 who underwent EUS due to other digestive problems than disease were enrolled. Features blood perfusion regions interest during CE-EUS analyzed quantitatively. The findings compared cytological and/or...