A5061233122- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- RNA modifications and cancer
- RNA regulation and disease
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- Genomics and Phylogenetic Studies
- Protein Kinase Regulation and GTPase Signaling
- Studies on Chitinases and Chitosanases
- Cancer-related molecular mechanisms research
- Tea Polyphenols and Effects
- Urinary and Genital Oncology Studies
- CRISPR and Genetic Engineering
- Multiple Myeloma Research and Treatments
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Potato Plant Research
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Toxin Mechanisms and Immunotoxins
Shanghai Jiao Tong University
2018-2025
Shanghai Cancer Institute
2018-2025
Academic Degrees & Graduate Education
2024
Renji Hospital
2023
State Key Laboratory of Oncogene and Related Genes
2018-2022
Sun Yat-sen University
2015-2016
SIRT6 is a member of the sirtuin family class III histone deacetylases. It plays important roles in regulating genomic stability, metabolism, stress response and aging. Our previous study has revealed that attenuates myocardial hypertrophy by inhibiting NF-κB activation, but related molecular mechanisms remain to be clarified. In present study, we showed p300 acetylase was involved protective effect against phenylephrine (PE)-induced cardiomyocyte hypertrophy. cultured neonatal rat...
Transcriptional machinery often operates in the configuration of biomolecular condensates, presenting emerging opportunities to develop therapies targeting transcriptionally addicted malignancies. In this study, we discovered that cyclin-dependent kinase 12 (CDK12), a key regulator transcription elongation, formed dynamic liquid-like droplets within nuclear speckles, process enhanced by high CDK12 expression and inhibitor treatment. Recognizing unique property, rationally designed ZSQ253,...
The activation of signal transducer and activator transcription 3 (STAT3) is critical for the development cardiac hypertrophy heart failure. Sirtuin 6 (SIRT6) protects cardiomyocytes from hypertrophy. This study focused on association between SIRT6 STAT3 in regulation cardiomyocyte In phenylephrine (PE)-induced hypertrophic model hearts isoprenaline-induced rat model, mRNA protein expressions its phosphorylated level at tyrosine 705 (P-STAT3) were significantly increased. By contrast,...
Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging therapeutic vulnerability in ovarian cancer. Here, we demonstrated that cancer exhibited unique dependency on the regulatory machinery of transcriptional termination, particularly, cleavage polyadenylation specificity factor (CPSF) complex. Genetic abrogation multiple CPSF subunits substantially hampered neoplastic cell viability, presented evidence their indispensable roles converged endonuclease CPSF3....
This study was aimed to investigate the crosstalk between protein kinase C ζ (PKCζ) and signal transducer activator of transcription 3 (STAT3) in cardiomyocyte hypertrophy. In neonatal rat hypertrophic model induced by phenylephrine (PE), levels phosphorylated PKCζ STAT3 were significantly increased, suggesting activation both Overexpression adenovirus infection elevated expressions markers atrial natriuretic factor (ANF) brains polypeptide (BNP), as well cell surface area; while genetic...
The transforming growth factor (TGF-β)-inducible early gene (TIEG1), a member of the Sp1/Krüppel-like family transcription factors, plays an important role in regulating cell growth, differentiation, and apoptosis many human diseases, including breast cancer, osteoporosis, atherosclerosis. However, little is known about TIEG1 heart. In this study, we investigated angiotensin II (Ang II)-induced cardiomyocyte hypertrophy its underlying mechanism. Our results showed that expression was...
Neuroendocrine bladder cancer (NEBC) poses a formidable clinical challenge and attracts keen interests to explore immunotherapy as viable treatment option. However, comprehensive immunogenomic landscape has yet be thoroughly investigated.
<p>Histopathological characteristics of NEBC and survival analysis in UBC.</p>
<p>Survival outcomes by immunotype in NEBC.</p>
<p>Chromoplexy events in NEBC.</p>
<p>p53 expression and mutational landscape in NEBC.</p>
<p>NMF analysis of NEBC mutational signatures.</p>
<p>Immunotype distribution and fibrotic barriers in NEBC.</p>
<p>Kataegis events in NEBC.</p>
<p>Radiographic evaluation and survival analysis in NEBC UBC.</p>
<p>Gene expression and immune repertoire in NEBC.</p>
<div>AbstractPurpose:<p>Neuroendocrine bladder cancer (NEBC) poses a formidable clinical challenge and attracts keen interests to explore immunotherapy as viable treatment option. However, comprehensive immunogenomic landscape has yet be thoroughly investigated.</p>Experimental Design:<p>Leveraging long-term cohort of natural NEBC cases, we employed multimodal approach integrating genomic (<i>n</i> = 19), transcriptomic 3), single-cell RNA sequencing 1),...
<p>Tumor purity, ploidy, and CNVs in NEBC.</p>