A5102228821- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Bladder and Urothelial Cancer Treatments
- Amoebic Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- COVID-19 Clinical Research Studies
- Heat shock proteins research
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Gastrointestinal disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Sepsis Diagnosis and Treatment
- Liver physiology and pathology
- Metabolism, Diabetes, and Cancer
- Galectins and Cancer Biology
- Infection Control and Ventilation
- COVID-19 diagnosis using AI
- Selenium in Biological Systems
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and healthcare impacts
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Renji Hospital
2024
Xi'an Jiaotong University
2019-2022
Chongqing Academy of Agricultural Sciences
2017
Fruit Research Institute
2017
Nanfang Hospital
2004
588 Background: High recurrence rate after curative resection significantly compromised the long-term survival of patients with HCC (pts). TACE as adjuvant therapy was proved to improve clinical outcomes for pts high risk factors hepatectomy. However, prognosis reminded unsatisfactory and controversial. Therefore, this study aimed identify efficacy safety anlotinib maintenance treatment following inductional in HCC. The preliminary results had been reported 2024 ASCO GI (Poster 513) update...
Effective systemic treatment for hepatocellular carcinoma (HCC) remains urgently needed. Sorafenib is the first FDA-approved HCC. However, individual HCC patents' response to sorafenib varies greatly. How enhance anti-HCC effect of still a significant challenge. T cell immunoglobulin mucin-3 (Tim-3) newly identified immune checkpoint molecule and promising target treatment. Herein, we developed novel pH-triggered drug-eluting nanoparticle ([email protected]&[email protected]) simultaneously...
Sorafenib (SRF) is recognized as the primary treatment for hepatocellular carcinoma (HCC), yet emergence of SRF resistance in many HCC patients results unfavorable outcomes. Enhancing efficacy remains a significant challenge. works inducing ferroptosis, form cell death, cancer cells through inhibition glutathione peroxidase 4 (GPX4). The effectiveness this process limited by low levels cellular iron and reactive oxygen species (ROS). A promising approach to circumvent limitation use...
The rat model of orthotopic liver transplantation (OLT) is essential for transplant research. It a very sophisticated animal and requires steep learning curve. introduction the cuff technique anastomosis portal vein (PV) infrahepatic vena cava (IHVC) has significantly simplified procedure in rats. However, due to short anterior wall recipients' suprahepatic (SHVC), difficult use reconstruction SHVC. Most researchers this field still hand-suture SHVC reconstruction, which makes it bottleneck...
Neuroendocrine bladder cancer (NEBC) poses a formidable clinical challenge and attracts keen interests to explore immunotherapy as viable treatment option. However, comprehensive immunogenomic landscape has yet be thoroughly investigated.
<p>Histopathological characteristics of NEBC and survival analysis in UBC.</p>
<p>Survival outcomes by immunotype in NEBC.</p>
<p>Chromoplexy events in NEBC.</p>
<p>p53 expression and mutational landscape in NEBC.</p>
<p>NMF analysis of NEBC mutational signatures.</p>
<p>Immunotype distribution and fibrotic barriers in NEBC.</p>
<p>Kataegis events in NEBC.</p>
<p>Radiographic evaluation and survival analysis in NEBC UBC.</p>
<p>Gene expression and immune repertoire in NEBC.</p>
<div>AbstractPurpose:<p>Neuroendocrine bladder cancer (NEBC) poses a formidable clinical challenge and attracts keen interests to explore immunotherapy as viable treatment option. However, comprehensive immunogenomic landscape has yet be thoroughly investigated.</p>Experimental Design:<p>Leveraging long-term cohort of natural NEBC cases, we employed multimodal approach integrating genomic (<i>n</i> = 19), transcriptomic 3), single-cell RNA sequencing 1),...
<p>Tumor purity, ploidy, and CNVs in NEBC.</p>
To explore the clinical characteristics of patients with symptomatic duodenal diverticula and to generalize how make appropriate treatment choices for this group patients.From January 2010 September 2020, a total 647 (DD) were included in study. 345 them relevant symptoms divided into other 302 asymptomatic group.Among all patients, most DD located periampullary area, <1 cm size, single number. The distribution localized 2nd portion/periampullary (P = 0.002/P < 0.001) 1 size cut-off value...
Abstract Background: Pyogenic liver abscess (PLA) is an inflammatory disease with increasing incidence. When it occurs diabetes mellitus (DM), risk of recurrence and the mortality may increase. However, effect DM on short-term prognosis PLA patients after hospitalization remained unknown.Methods: 227 who received treatment at First Affiliated Hospital Xi’an Jiaotong University from January 2011 to 2018 were retrospectively enrolled. They divided into two groups as group (n=61) Non-DM...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and aim this study to clarified mechanisms on early activation HSF1 role in pancreatic cancer Methods: The expression location human or mice tissues were examined by immunohistochemically staining. mainly used acinar cell 3-dimensional (3D) culture a spontaneous precancerous...
Abstract Background: Pyogenic liver abscess (PLA) is an inflammatory disease with increasing incidence. When it occurs diabetes mellitus (DM), risk of recurrence and the mortality may increase. However, effect DM on short-term prognosis PLA patients after hospitalization remained unknown. Methods: 227 who received treatment at First Affiliated Hospital Xi’an Jiaotong University from January 2011 to 2018 were retrospectively enrolled. They divided into two groups as group (n=61) Non-DM...
Abstract Background Gas-forming pyogenic liver abscess (GFPLA) accounts for up to 30% of all (PLA) cases. However, little is known the differences in clinical features and prognosis between GFPLA non-GFPLA. Aim This retrospective study compared Methods Data 392 patients with PLA treated from 1 January 2007 31 December 2016 were reviewed. was defined as gas abscess. Liver abscesses considered non- (n = 326) or 66). The outcomes relative that without GFPLA. Results groups similar gender ratio,...