A5100428326- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Heat shock proteins research
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Healthcare and Venom Research
- Thyroid Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Renal and related cancers
- Angiogenesis and VEGF in Cancer
- Enzyme Structure and Function
- Renal cell carcinoma treatment
- Cancer Treatment and Pharmacology
- RNA Research and Splicing
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Guangzhou Medical University
2023-2025
Nanjing Medical University
2012-2024
Shandong University
2024
Jinan Central Hospital
2024
Ningbo Medical Center Lihuili Hospital
2022-2024
Jiangsu Province Hospital
2012-2024
Sixth Affiliated Hospital of Kunming Medical University
2024
Dali University
2024
m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process found be upregulated cancers, including CRC. Here, we investigate and underlying mechanism of development CRC.The expression was detected large clinical patient samples. To evaluate function vitro vivo, colony formation, CCK-8, cell migration invasion assays were performed. find out downstream target METTL3, GEO dataset re-mined. We analyzed...
Abstract The PI3K–AKT signaling pathway is frequently dysregulated in cancer, and it hyperactivated approximately 50% of breast cancers. Although inhibitors directly targeting the axis have been developed, clinical efficacy has limited to only a subset patients. Identification mechanisms underlying AKT-driven tumorigenesis could lead alternative approaches block suppress tumor growth. Mass spectrometry–based analyses demonstrated that salt-inducible kinase 1 (SIK1) binds AKT undergoes...
Abstract Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly breast cancer. This study demonstrates that triple‐negative cancer (TNBC) bears relatively elevated copper levels and exhibits resistance to cuproptosis. Mechanistically, activates the AKT signaling which inhibits ferredoxin‐1 (FDX1), key regulator of AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis aerobic respiration but...
Objective: We investigated the molecular mechanism underlying role of monocyte chemoattractant protein-1 (MCP-1) in formation and development human abdominal aortic aneurysm (AAA). Methods: examined protein expression profiles using a array found that MCP-1 was most highly expressed AAA tissues compared with normal aortas. To investigate potential involvement pathogenesis AAA, we treated smooth muscle cells (HASMCs) recombinant MCP-1. Results: aorta; matrix metalloproteinase-9 (MMP-9) also...
Gemcitabine is a standard treatment for advanced pancreatic cancer patients but can cause chemoresistance during treatment. The chemoresistant cells have features of stem (CSCs). Resveratrol has been reported to overcome the resistance induced by gemcitabine. However, mechanism which resveratrol enhances chemosensitivity remains elusive. Here, we explored enhanced and role sterol regulatory element binding protein 1 (SREBP1) in gemcitabine-induced stemness.The cell lines MiaPaCa-2 Panc-1...
Abstract Previous studies have shown that the addition of carboplatin to neoadjuvant chemotherapy improved pathologic complete response (pCR) rate in patients suffering from triple‐negative breast cancer (TNBC) and who obtained a pCR could achieve prolonged event‐free survival (EFS) overall (OS). However, no assessed effects combination docetaxel without anthracycline with taxane‐based anthracycline‐based regimens. The NeoCART study was designed as multicenter, randomized controlled,...
Palmitoylation is essential for the classic hallmarks of cancers through regulating protein stability and protein-protein interactions.ZDHHC22, as a well-known member palmitoyltrans-ferase family, its role has not been revealed in cancer.We found ZDHHC22 expression was significantly lower estrogen receptor (ER) negative breast cancer (BrCa) tissues cell lines, positively corelated with clinical prognosis BrCa patients.The might be caused by promoter methylation.ZDHHC22 inhibited...
PRL-3, a protein tyrosine phosphatase, has attracted much attention as its transcript is consistently upregulated in the process of colorectal cancer metastases to secondary organs. We studied mice injected via tail vein with CHO cells stably expressing EGFP-tagged PRL-3 or catalytically inactive mutant (C104S). Our data showed that EGFP-PRL-3-expressing rapidly induce metastatic tumor formation lung, while EGFP-PRL-3 (C104S)-expressing lose this metastastic activity. Furthermore, detailed...
Abstract Papillary thyroid carcinoma (PTC) is heterogeneous and its molecular characteristics remain elusive. We integrated transcriptomic sequencing, genomic analysis clinicopathologic information from 582 tissue samples of 216 PTC 75 benign nodule (BTN) patients. discovered four subtypes including Immune-enriched Subtype, BRAF-enriched Stromal Subtype CNV-enriched Subtype. Molecular were validated in an external cohort 497 cases the TCGA. Tumors showed higher immune infiltration...
Abstract Lipid metabolism plays a crucial role in maintaining bone homeostasis, particularly osteoclasts (OCs) formation. Here, we found that the expression level of FATP2, transporter for long-chain and very-long-chain fatty acids, was significantly upregulated during OC differentiation marrow mice fed high-fat diet (HFD). Notably, use FATP2 siRNA or specific inhibitor (Lipofermata) resulted significant inhibition differentiation, while only slightly affecting osteoblasts. In pathological...
Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite significance, present treatment for brain simply provides symptomatic relief the fact that molecular mechanisms underlying remain poorly understood. The study investigated role of hypoxia-inducible factor-1α (HIF-1α) aquaporins (AQP-4 -9) in regulating cerebral glycerol accumulation inducing rodent model stroke. Two-hours middle artery occlusion (MCAO) followed...
H3K27me3 modification inactivates gene transcription by resulting in condensed chromatin. However, the landscape and biological functions of breast cancer remain unclear.Fluorescence enzyme assay was used to analyze cell proliferation. Transwell test ability migration invasion MDA-MB-231 cells with designed treatment. Transfection exogenous plasmid intervene specific expression. Nude mouse tumor xenograft model employed detect effect GSKJ-4 vivo. ChIP-Seq analyzed state around TSS CEMIP....
Abstract Colorectal cancer (CRC) is a common digestive tract malignancy, which characterized by high mortality, morbidity, and poor prognosis. Replication factor C subunit 2 (RFC2), one RFC family member, was reported to be related various malignancies plays an important role in proliferation, invasion, metastasis. Nonetheless, the RFC2 biological within CRC still unknown. expression profiles tissues were collected based on The Cancer Genome Atlas database, whereas miR‐744 levels detected...
Abstract Lipid metabolism reprogram plays key roles in breast cancer tumorigenesis and immune escape. The underlying mechanism potential regulator were barely investigated. We thus established an vivo model, mice-bearing cells treated with ordinary diet high-fat diet, species collected subjected to circRNA sequence scan the circRNAs regulating lipid metabolism. CircSpdyA was one of most upregulated had encode a 127-aa micro peptide (referred as 127aa). 127 aa promotes through promoting fatty...