A5102945417- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- DNA Repair Mechanisms
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Salivary Gland Disorders and Functions
- Acute Kidney Injury Research
- Lung Cancer Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Case Reports on Hematomas
- Thyroid and Parathyroid Surgery
- Sepsis Diagnosis and Treatment
- Bone fractures and treatments
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Thyroid Disorders and Treatments
- Cancer-related gene regulation
- Trigeminal Neuralgia and Treatments
- Colorectal Cancer Treatments and Studies
Sun Yat-sen University
2018-2025
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Eli Lilly (United States)
2008-2025
Hangzhou Medical College
2023-2024
Zhejiang Provincial People's Hospital
2023-2024
Peking University Shenzhen Hospital
2017-2024
Pingliang People's Hospital
2024
University of Science and Technology of China
2024
Fujian Inspection and Research Institute for Product Quality
2024
Key Laboratory of Guangdong Province
2022-2023
<h3>Importance</h3> Owing to the good prognosis of differentiated thyroid cancer (DTC), guidelines recommend total thyroidectomy (TT) or lobectomy (TL) as surgical treatment for DTC with low intermediate risk recurrence. However, association these surgeries health-related quality life (HRQOL) patients recurrence is unclear. <h3>Objective</h3> To longitudinally compare HRQOL undergoing different surgeries. <h3>Design, Setting, and Participants</h3> This prospective observational longitudinal...
Lymph node metastasis (LNM) assessment in patients with papillary thyroid carcinoma (PTC) is of great value. This study aimed to develop a deep learning model applied intraoperative frozen section for prediction LNM PTC patients.We established deep-learning (ThyNet-LNM) the multiple-instance framework predict using whole slide images (WSIs) from sections PTC. Data development and validation ThyNet-LNM were retrospectively derived four hospitals January 2018 December 2021. The was trained...
H3K27me3 modification inactivates gene transcription by resulting in condensed chromatin. However, the landscape and biological functions of breast cancer remain unclear.Fluorescence enzyme assay was used to analyze cell proliferation. Transwell test ability migration invasion MDA-MB-231 cells with designed treatment. Transfection exogenous plasmid intervene specific expression. Nude mouse tumor xenograft model employed detect effect GSKJ-4 vivo. ChIP-Seq analyzed state around TSS CEMIP....
BackgroundRAD51D is involved in DNA double-strand break repair by homologous recombination and plays an important role the maintenance of genomic stability. The associations between RAD51D germline mutations breast cancer risk survival are not fully elucidated.Patients methodsRAD51D were determined using a multigene panel 7657 unselected patients who negative for BRCA1/2 mutations. recurrent mutation p.K91fs was screened 7947 healthy controls Sanger sequencing.ResultsA total 29 cases (0.38%)...
To investigate the association between thyroid functions and oral microbiome diversity.Data from US National Health Nutrition Examination Survey (NHANES; 2009-2012) were analyzed. Thyroid defined using hormones related biomarkers. Oral was measured observed number of amplicon sequence variants (ASVs) Bray-Curtis dissimilarity. Linear regression used to estimate average change (β) 95% CI for ASVs against functions, adjusted sociodemographic variables, health conditions, urinary iodine status,...
Background: Factors contributing to the development of reproductive concern, fertility intention and pregnancy outcomes in young women following thyroidectomy are unclear. This study aimed compare intentions between who had either thyroid cancer (TC) or benign disease were treated with total (TT) lobectomy (TL). Methods: prospective cohort enrolled aged 20-40 scheduled for surgery at a tertiary hospital China from November 2019 October 2021 (ChiCTR1900027205). Reproductive concern evaluated...
This study examined the pathological complete response (pCR) rate and safety of sequential gemcitabine-based combinations in breast cancer. We also gene expression profiles from tumour biopsies to identify biomarkers predictive response. Indian women with large or locally advanced cancer received 4 cycles gemcitabine 1200 mg m−2 plus doxorubicin 60 (Gem+Dox), then 1000 cisplatin 70 (Gem+Cis), surgery. Three alternate dosing sequences were used during cycle 1 examine dynamic changes molecular...
Abstract Exploring indoleacetic acid (IAA) biosynthesis pathways of plant growth promoting bacteria and their ability to synthesize IAA is crucial for understanding the promotion mechanism developing more efficient microbial fertilizer. In this study, 118 bacterial endophytic strains were isolated from tomato root 68 isolates identified as members Bacillus Pseudomonas genus. After screening abilities in vitro promote these strains, 7 sp. Y_21, B. paramycoides Y_29, albus Y_96, cereus Y_121,...
The prevalence of BRCA1/2 large genomic rearrangements (LGRs) and their underlying mechanisms have not been fully evaluated in Chinese women with breast cancer. In this study, we determined the LGRs 834 patients familial cancer (FBC) 660 sporadic triple-negative (TNBC) who were negative for small-range mutations using multiplex ligation-dependent probe amplification method. We found that 20 index (2.4%) FBC group carried a BRCA1 or BRCA2 LGR, frequencies 1.6% 0.8%, respectively. Seven (1.1%)...
The objective of this study was to develop an electrophysiological method for intraoperative localization the trigeminal nerve branches during radiofrequency thermocoagulation (RFTC).Twenty-three patients who were scheduled undergo RFTC included. root stimulated through foramen ovale using cannula. Antidromic responses recorded from target division supraorbital, infraorbital, and mental foramina electrodes, additional electrode at masseter muscle. Sensory motor action responses, as well...
Background Anaplastic thyroid cancer is the most aggressive and has a poor prognosis. At present, there no effective treatment for it. Methods Here, we used different concentrations of GSK-J4 or combination doxorubicin to treat human Cal-62, 8505C 8305C anaplastic cell lines. The in vitro experiments were performed using viability assays, cycle annexin-V/PI binding Transwell migration assays wound-healing assays. Tumor xenograft models observe effects vivo. Results half maximal inhibitory...
Abstract Background Papillary thyroid cancer (PTC) is the most common type of and incidence PTC has continued to increase over past decades. Many studies have shown that obesity an independent risk factor for obese patients tend a relative larger tumor size higher grade stage. Obesity associated with disordered lipid metabolism relationship between serum lipids remains unclear. Therefore, this study aimed investigate association level PTC. Methods We retrospectively analyzed 1018 diagnosed...
Background: Repair of long-span mandibular defects with vascularized free fibular grafts is now a routine procedure. Vertical discrepancy between graft segment and the occlusal plane can be resolved through several options, including delayed onlay bone graft, iliac reconstruction, fibula distraction, double-barrel flap grafts. The present study (level evidence: level IV, case series) introduces new method for augmentation, wherein was used to simulate superior alveolar ridge neomandible,...
Objectives . To investigate whether botulinum toxin type A (BTXA) could control excessive secretion after submandibular gland (SMG) transplantation in rabbits and its possible mechanisms. Methods new SMG model was established rabbit. 30 successfully constructed models were randomly assigned to five groups including group four experimental groups. Secretion outputs used analyze the effect of BTXA injection on secretion. Hematoxylin eosin (HE) staining, transmission electron microscopy (TEM),...