A5100606929- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Aortic Disease and Treatment Approaches
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Shanghai Institute of Hematology
2015-2025
Shanghai Jiao Tong University
2016-2025
University of Science and Technology of China
2020-2025
Jilin University
2025
Quzhou City People's Hospital
2020-2024
Wenzhou Medical University
2004-2024
Ruijin Hospital
2012-2024
Shanxi Medical University
2024
Southern Medical University
2024
Wenzhou Central Hospital
2024
Significance Anthracyclines like doxorubicin are anticancer drugs, used by over 1 million cancer patients annually. However, they cause severe side effects, most notably, cardiotoxicity and therapy-related malignancies. It is unclear whether these effects directly linked to their activity. Doxorubicin exerts two activities: DNA damage chromatin damage. Here, we show that both activities conspire in the cardiotoxicity, while variants with only chromatin-damaging activity remain active drugs...
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) trigger for pathological changes such as cell apoptosis disordered immune microenvironments, are crucial progression UC can be promising therapeutic target. Nowadays, development targeted strategies still in its infancy. Thus, developing effective therapies based on ROS...
Hemophilic articular cartilage damage presents a significant challenge for surgeons, characterized by recurrent intraarticular bleeding, severe inflammatory microenvironment, and limited self-repair capability of tissue. Currently, there is lack tissue engineering-based integrated therapies that address both early hemostasis, anti-inflammation, long-lasting chondrogenesis hemophilic defects. Herein, we developed an adhesive hydrogel using oxidized chondroitin sulfate gelatin, loaded with...
Abstract Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated pathways, promoted...
Objective: LGALS3BP exhibits differential expression in various types of tumors. This study aimed to analyze its potential diagnostic and prognostic value Triple- negative Breast Cancer (TNBC). Methods: We conducted a comprehensive analysis LGALS3BP's association with patient survival outcomes using data from public databases. To further validate these findings, Immunohistochemistry (IHC) experiments were performed confirm the protein TNBC. Additionally, we also investigated relationship...
The association of plasma metals on the risk cardiovascular diseases (CVD) in adults with prediabetes remains poorly investigated. To assess between metal exposure and CVD prediabetic United States using five metals. Five cycles data (2011–2012, 2013–2014, 2015–2016, 2017–2018) from NHANES were adopted this study. measured 1088 participants prediabetes. We utilized multivariate logistic regression, WQS, BKMR models to evaluate associations CVD. found link 2nd quartile, 3rd 4th quartiles...
This study aimed to explore the potential correlation between metabolic intermediate L-2-hydroxyglutarate (L-2-HG) and T cell exhaustion, as well underlying mechanisms involved. In this study, we investigated presence of exhausted cells (Tex) in patients under certain conditions: HIV infection, chronic leukemia, hepatocellular carcinoma. To gain insights into epigenetic signatures transcriptome alterations Tex, employed a combination RNA-seq ATAC-seq analyses. evaluate impact L-2-HG on...
Abstract Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway cell cycle control known aberrant in large proportion cancers. Recently, CDK4 inhibitors successfully used pre-clinically treatment many human cancers, and 2015, following success clinical...
Cancer stem cell theory has been proposed to explain tumor heterogeneity and the carcinogenesis process. Highly tumorigenic lung cancer cells develop resistance cisplatin (CDDP), a common chemotherapy drug. Herein, we attempted clarify whether apigenin (API) can improve antitumor efficiency of CDDP in using cells. Lung were identified as CD 133 positive non-small (NSCLC) A549, H1299 CDDP-resistant NSCLC A549R The cytotoxic effect API was measured CDDP-treated H1299, repressed enhanced...