A5017608428- Sarcoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- CAR-T cell therapy research
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Advanced Breast Cancer Therapies
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- DNA and Nucleic Acid Chemistry
- Tumors and Oncological Cases
- Autophagy in Disease and Therapy
- Diversity and Career in Medicine
- COVID-19 Clinical Research Studies
- Protein Degradation and Inhibitors
- LGBTQ Health, Identity, and Policy
- Vascular Malformations and Hemangiomas
- Circular RNAs in diseases
- Names, Identity, and Discrimination Research
- Parvovirus B19 Infection Studies
- ATP Synthase and ATPases Research
University of Oxford
2021-2024
Royal Prince Alfred Hospital
2023-2024
Guy's and St Thomas' NHS Foundation Trust
2024
The University of Sydney
2012-2020
University of California, Los Angeles
2018-2019
Sarcoma Oncology Center
2017-2018
University of Washington
2018
Massachusetts General Hospital
2017
Harvard University
2017
Robert Bosch (Australia)
2012-2015
We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT) and 2-benzoylpyridine (BpT) ligands to improve the efficacy safety profile these potential antitumor agents. Two novel DpT analogues, Dp4e4mT DpC, exhibited pronounced selective activity against human lung cancer xenografts in vivo via intravenous oral routes. Importantly, analogues did not induce cardiotoxicity observed at high nonoptimal doses first-generation analogue, Dp44mT. The Cu(II) complexes...
The intracellular distribution of a drug can cause significant variability in both activity and selectivity. Herein, we investigate the mechanism by which anti-cancer agents, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) clinically trialed, 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), re-instate efficacy doxorubicin (DOX), drug-resistant P-glycoprotein (Pgp)-expressing cells. Both Dp44mT DpC potently target kill Pgp-expressing tumors, while DOX effectively kills...
BackgroundCyclin-dependent protein kinase 9 (CDK9) has been shown to play an important role in the pathogenesis of malignant tumors. However, expression and function CDK9 remain unknown osteosarcomas. The purpose this study is assess expression, clinical prognostic relationship osteosarcomas.MethodsA tissue microarray 70 patient specimens was analyzed by immunohistochemistry measure which further investigated for correlation with characteristics. osteosarcoma cell lines tissues also...
Cancer cells develop resistance to stress induced by chemotherapy. In tumours, a considerable glucose gradient exists, resulting in stress. Notably, hypoxia-inducible factor-1 (HIF-1) is redox-sensitive transcription factor that regulates P-glycoprotein (Pgp), crucial drug-efflux transporter involved multidrug (MDR). Here, we investigated how levels regulate Pgp-mediated drug transport and resistance.Human tumour (KB31, KBV1, A549 DMS-53) were incubated under starvation hyperglycaemic...
Pgp is functional on the plasma membrane and lysosomal membrane. Lysosomal-Pgp can pump substrates into organelle, thereby trapping certain chemotherapeutics (e.g. doxorubicin; DOX). This mechanism serves as a "safe house" to protect cells against cytotoxic drugs. Interestingly, in contrast DOX, sequestration of novel anti-tumor agent P-glycoprotein (Pgp) substrate, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), induces permeabilization. lysosomal-Pgp utilization enhances...
Abstract Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway cell cycle control known aberrant in large proportion cancers. Recently, CDK4 inhibitors successfully used pre-clinically treatment many human cancers, and 2015, following success clinical...
Sir: Recent studies estimate the prevalence of transgender individuals in global population to be between 0.4 and 1.3 percent, with a 10- 100-fold increase past decade.1 As there has been an proportion undergoing gender affirmation surgery,2 it would expected that information on these procedures increasingly sought by patients, their families, providers. Social media Internet play significant role dissemination for population.3 However, no study date determine overall public interest...
ABSTRACT Synovial sarcomas hold a low genomic complexity, making it distinct from other types of soft‐tissue sarcomas. Many studies focused on targeting the SS18‐SSX fusion protein, which presents in over 90% human synovial This protein acts as an oncogenic promoter tumorigenesis sarcomas, ideal therapeutic target. However, to date there have been no effective strategies for treatment Therefore, is urgent need identify alternative targets. More recently, CDK9, involved RNA transcription...
Summary Cancer patients with COVID-19 have reduced survival. While most cancer patients, like the general population, an almost 100% rate of seroconversion after infection or vaccination, haematological malignancies lower rates and are far less likely to gain adequate protection. This raises concern that malignancies, especially those receiving immunosuppressive therapies, may still develop fatal disease when infected vaccination. There is urgent need Guidelines help direct vaccination...
Mechanisms involved in the individual susceptibility to atherosclerotic coronary artery disease (CAD) beyond traditional risk factors are poorly understood. Here, we describe utility of cultured patient-derived endothelial colony-forming cells (ECFCs) examining novel mechanisms CAD susceptibility, particularly role dysregulated redox signalling. ECFCs were selectively from peripheral blood mononuclear 828 patients BioHEART-CT cohort, each with corresponding demographic, clinical and CT...