A5056284397- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Immune cells in cancer
- Autoimmune and Inflammatory Disorders Research
Dalian University
2024
Dalian University of Technology
2024
Renji Hospital
2023
Shanghai Jiao Tong University
2023
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) trigger for pathological changes such as cell apoptosis disordered immune microenvironments, are crucial progression UC can be promising therapeutic target. Nowadays, development targeted strategies still in its infancy. Thus, developing effective therapies based on ROS...
Ulcerative colitis (UC) is difficult to cure and easy relapse, leading poor quality of life for patients. Oxymatrine (OMT) one the main alkaloids Sophora flavescens Aiton, which has many effects, such as anti-inflammation, anti-oxidative stress, immunosuppression. This study aimed investigate whether OMT could attenuate ulcerative by inhibiting NOD-like receptor family pyrin domain containing three (NLRP3) inflammasome-mediated pyroptosis. In this study, UC rat models were established...