A5070182163- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Kawasaki Disease and Coronary Complications
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Heme Oxygenase-1 and Carbon Monoxide
- Macrophage Migration Inhibitory Factor
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- interferon and immune responses
- Advanced Nanomaterials in Catalysis
- Cardiac Arrest and Resuscitation
- Endoplasmic Reticulum Stress and Disease
- HVDC Systems and Fault Protection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Valve Diseases and Treatments
Second Affiliated Hospital of Zhejiang University
2023-2025
Zhongshan Hospital
2020-2024
Fudan University
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Nanchang University
2018-2023
Second Affiliated Hospital of Nanchang University
2018-2023
Shanghai Institute of Hematology
2022
Temple College
2022
Michigan United
2022
[Figure: see text].
Abstract Ischemia reperfusion injury (IRI) is a common cause of acute kidney (AKI). The role N 6- methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the AlkB homolog 5 (ALKBH5) and m6A an I/R-induced renal model male mice. Alkbh5 -knockout mice exhibit milder pathological damage better function than wild-type post-IRI, whereas -knockin show contrary results. Also conditional knockout tubular epithelial cells alleviates fibrosis. CCL28 identified as target...
Doxorubicin is an effective chemotherapy drug for treating various types of cancer. However, lethal cardiotoxicity severely limits its clinical use. Recent evidence has indicated that aberrant activation the cytosolic DNA-sensing cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-STING (stimulator interferon genes) pathway plays a critical role in cardiovascular destruction. Here, we investigate involvement this mechanism doxorubicin-induced (DIC). Mice were treated with...
It is known that mitochondrial dysfunction a critical factor involved in myocardial ischemia–reperfusion injury. Mitochondrial transplantation has been suggested as an effective therapeutic strategy to protect against However, its clinical translation remains limited because it requires the local injection of mitochondria into myocardium. Here, polypeptide, CSTSMLKAC (PEP), bound triphenylphosphonium cations (TPP+) effectively binds form PEP–TPP–mitochondrial compound. Further investigation...
The Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene is closely associated with myocardial ischaemia/reperfusion injury (I/RI). effects of ALDH2 on neutrophil extracellular trap (NET) formation (i.e. NETosis) during I/RI remain unknown. This study aimed to investigate role NETosis pathogenesis I/RI.
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) trigger for pathological changes such as cell apoptosis disordered immune microenvironments, are crucial progression UC can be promising therapeutic target. Nowadays, development targeted strategies still in its infancy. Thus, developing effective therapies based on ROS...
Abstract The role of M1 macrophages (M1M)-derived exosomes in the progression neointimal hyperplasia remains unclear now. Using a transwell co-culture system, we demonstrated that M1M contributed to functional change vascular smooth muscle cell (VSMC). We further stimulated VSMCs with isolated from M1M. Our results these could be taken up by through macropinocytosis. microRNA array assay, identified miR-222 originated M1M-derived triggered changes VSMCs. In addition, confirmed played key...
Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion (I/R) injury and can be alleviated via the mitochondrial transplantation. The efficiency of transplantation determined by vitality. Because aldehyde dehydrogenase 2 (ALDH2) has key role regulating homeostasis, we aimed to investigate its potential therapeutic effects on use ALDH2 activator, Alda-1. Our present study demonstrated that time-dependent internalization exogenous mitochondria cardiomyocytes along with ATP...
Abstract Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via caspase-11/GSDMD pathway. We also found GSDMD deletion attenuated MI by reducing cardiomyocyte pyroptosis. However, how mediates protects function remains unclear. Here, we doxorubicin (DOX) treatment resulted increased cardiomyocytes could mediate DOX-induced cardiotoxicity (DIC)...
N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an "eraser", is responsible for decreased modification. However, its role in cardiac fibroblasts during the post-myocardial infarction (MI) healing process remains elusive.
BACKGROUND: Senescent foamy macrophages are key drivers of atherosclerosis and plaque instability. N 6 -methyladenosine (m A) modification RNA plays an important role in the development various diseases including aging. Here, we aim to investigate m A formation senescent atherosclerosis. METHODS: To assess methylation, were isolated from atherosclerotic plaques patients with atherosclerosis, Apoe −/− mice fed a high-fat diet using CD68 + magnetic beads. An ALKBH5 (alkB homolog 5) f/f , Lyz2...
Background Dilated cardiomyopathy (DCM), characterized by progressive left ventricular enlargement and systolic dysfunction, is the most common type of a leading cause heart failure cardiac death. Accumulating evidence underscores critical role genetic defects in pathogenesis DCM, >250 genes have been implicated DCM to date. However, substantial heterogeneity, basis underpinning remains elusive cases. Methods Results By genome-wide scan with microsatellite markers linkage analysis...
Abstract Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S promote the degradation cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that was significantly upregulated transverse aortic constriction (TAC)-induced hypertrophic hearts angiotensin II (Ang II)-treated cardiomyocytes. deficiency ameliorated pressure overload-induced were associated with inhibition reactive...
Ketone body oxidation yields more ATP per mole of consumed oxygen than glucose. However, whether an increased ketone supply in hypoxic cardiomyocytes and ischemic hearts is protective or not remains elusive. The goal this study to determine the effect β-hydroxybutyrate (β-OHB), main constituent bodies, on under conditions effects ketogenic diet (KD) cardiac function a myocardial infarction (MI) mouse model.Human peripheral blood collected from patients with acute healthy volunteers was used...
Adenosine kinase (ADK) plays the major role in cardiac adenosine metabolism, so that inhibition of ADK increases myocardial levels. While cardioprotective actions extracellular against ischemia/reperfusion (I/R) are well-established, cellular protection I/R remains unknown. Here we investigated epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to I/R. Evans blue/TTC staining echocardiography were used assess extent injury mice. Glucose was evaluated by...
Insufficient angiogenic stimulation and dysregulated glycolipid metabolism in senescent vascular endothelial cells (VECs) constitute crucial features of aging. Concomitantly, the generation excess senescence-associated secretory phenotype (SASP) active immune-inflammatory responses propagates within injured vessels, tissues, organs. Until now, targeted therapies that efficiently rectify phenotypic abnormalities VECs have still been lacking. Here, we constructed a Pd/hCeO2–BMS309403@platelet...
The clinical application of anthracyclines such as doxorubicin (DOX) is limited due to their cardiotoxicity. N6-methyladenosine (m6A) plays an essential role in numerous biological processes. However, the roles m6A and demethylase ALKBH5 DOX-induced cardiotoxicity (DIC) remain unclear. In this research, DIC models were constructed using Alkbh5-knockout (KO), Alkbh5-knockin (KI), Alkbh5-myocardial-specific knockout (ALKBH5flox/flox, αMyHC-Cre) mice. Cardiac function DOX-mediated signal...