A5100683085- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Moyamoya disease diagnosis and treatment
- Plant Gene Expression Analysis
- Phagocytosis and Immune Regulation
- Lymphoma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Birth, Development, and Health
- Plant Molecular Biology Research
- Intracranial Aneurysms: Treatment and Complications
- Plant nutrient uptake and metabolism
- Plant responses to water stress
- CAR-T cell therapy research
- Alcohol Consumption and Health Effects
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Cardiovascular Health and Risk Factors
- Immune Response and Inflammation
- Engineering and Technology Innovations
- Innovative Energy Harvesting Technologies
Tobacco Research Institute
2024-2025
China Tobacco
2024-2025
Tongji University
2016-2025
Henan University of Science and Technology
2019-2025
Tumor Hospital of Xinjiang Medical University
2024
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2024
Xinjiang Medical University
2020-2024
Zhengzhou University
2021-2024
Shenzhen Municipal People's Government
2024
Shenzhen University
2024
Diabetic tubulopathy (DT) is a recently recognized key pathology of diabetic kidney disease (DKD). The mitochondria-centric view DT emerging as vital pathological factor in different types metabolic diseases, such DKD. Finerenone (FIN), novel non-steroidal mineralocorticoid receptor antagonist, attenuates inflammation and fibrosis DKD, but the precise pathomechanisms remain unclear. role (MR) perturbing mitochondrial function via PI3K/Akt/eNOS signaling pathway, including dynamics mitophagy,...
Parkinson's disease (PD) is a neurodegenerative characterized by loss of dopaminergic neurons in the substantia nigra. Diosgenin natural steroid saponin which was shown to play beneficial role Alzheimer's disease.This study sought investigate potential effect diosgenin on rat model PD.Sprague Dawley rats were subjected intra-striatal injection lipopolysaccharide (LPS) and treated with diosgenin. Stepping, Whisker, Cylinder tests carried out determine motor function, expression tyrosine...
Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR in nondiabetic animal models. However, its on diabetic the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, infarct volume, brain edema, cell viability, reduced mitochondrial swelling,...
Sucrose phosphate synthase (SPS) is an important enzyme in the sucrose synthesis of plants, governing accumulation and distribution photosynthetic assimilates, which essential for plant growth stress tolerance. This study successfully identified eight NtSPS genes within genome cultivated tobacco. Phylogenetic analysis revealed that these are categorized into three subfamilies, a classification supported by examination their gene structures conserved domains. The promoters NtSPSs contained...
The leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is an inhibitory expressed on the majority of peripheral blood mononuclear cells and important for regulation immune responses. binding LAIR-1 to its ligands results in loss function tumor microenvironment (TME) a reduction T cell responses antigen-presenting cells. Using bioinformatics analysis, we showed that broadly upregulated multiple types cancer. By designing LAIR-2-Fc recombinant protein block ligand collagen, observed...
Abstract Objectives Construct and validate a nomogram model integrating the radiomics features clinical risk factors to differentiating axial spondyloarthritis (axSpA) in low back pain patients undergone sacroiliac joint (SIJ)-MRI. Methods A total of 638 confirmed as axSpA (n = 424) or non-axSpA 214) who were randomly divided into training 447) validation cohorts 191). Optimal signatures constructed from 3.0 T SIJ-MRI using maximum relevance–minimum redundancy (mRMR) least absolute shrinkage...
Background: Serine proteinase inhibitor A3 (SERPINA3) has been discovered in the pathogenesis of many human diseases, but little is known about role SERPINA3 coronary artery disease (CAD). Therefore, we aim to determine its relationship with CAD and function atherosclerosis. Methods: In total 86 patients 64 non-CAD were compared. The plasma levels measured using ELISA. Logistic regression analysis receiver-operating characteristic (ROC) performed illustrate association between CAD. vitro,...
Triple-negative breast cancer (TNBC) is the most malignant subtype of cancer, and it associated with a high recurrence rate, metastatic potential, poor prognosis. Thus, effective therapeutic strategies for TNBC are urgently required. The epidermal growth factor receptor (EGFR) considered to be potential target TNBC. However, there limitations use targeted therapies, such as afatinib (AFT), particularly drug resistance. Here, we investigated poly(d,l-lactide-glycolide) (PLGA)-based...
Since tumors are often infiltrated by macrophages, it would be advantageous to turn these types of cells into cytotoxic effector cells. Here, we have designed a novel bispecific antibody (BsAb) that targets both tumor antigen (CD20) and the FcαRI receptor (CD89). This could used lyse connecting CD89-expressing immune such as macrophages neutrophils. Previously there were very limited attempts exploit FcαRI-expressing for cell-killing, largely due lack an appropriate in vivo model, since mice...
B7-H3 plays an important role in tumor apoptosis, proliferation, adhesion, angiogenesis, invasion, migration, and evasion of immune surveillance. It is overexpressed various human solid tissues. In patients, overexpression correlates with advanced stages, poor clinical outcomes, resistance to therapy. The roles progression make it a potential candidate for targeted Here, we generated mouse anti-human antibody demonstrated its binding activity via Tongji University Suzhou...
Immunotherapy is an effective method for tumour treatment. Anti-programmed cell death protein 1 (PD-1) and anti-programmed death-ligand (PD-L1) monoclonal antibodies play a significant role in immunotherapy of most tumours; however, some patients develop drug resistance to PD-1/PD-L1 therapy. Cyclooxygenase-2 (COX2) expressed various solid tumours, prostaglandin E2 (PGE2) drives the development malignant tumours. We developed drug-resistant B16F10 (B16F10-R) mouse model through four rounds...
Adenosine kinase (ADK) plays the major role in cardiac adenosine metabolism, so that inhibition of ADK increases myocardial levels. While cardioprotective actions extracellular against ischemia/reperfusion (I/R) are well-established, cellular protection I/R remains unknown. Here we investigated epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to I/R. Evans blue/TTC staining echocardiography were used assess extent injury mice. Glucose was evaluated by...
Therapeutic antibodies are effective for tumor immunotherapy and exhibit prominent clinical effects. All approved antibody therapeutics utilize IgG as the molecular format. Antibody-dependent cell-mediated cytotoxicity (ADCC) is a key mechanism cell killing by antibodies. For antibodies, ADCC depends on FcγR-expressing cells, such natural killer (NK) cells. However, in patients with high burden, may lose efficacy owing to exhaustion of effector cells well inhibitory effects certain FcγRs To...
Abstract As an inhibitor of STAT3, BP‐1‐102 can regulate the inflammation response caused by vascular smooth muscle cells (VSMCs) inhibiting JAK/STAT3/NF‐κB pathway, thereby attenuating symptoms intracranial aneurysm (IA). IA mouse model was established stereotactic injection elastase to evaluate effect BP‐1‐102. The expression levels markers and matrix metalloproteinases (MMPs) were detected qRT‐PCR, inflammatory factors ELISA qRT‐PCR. protein NF‐κB signaling pathway examined Western blot....
As a leading cause of maternal and neonatal morbidity mortality, preeclampsia (PE) remains enigmatic. We confirmed that PE is associated with gut dysbiosis. However, whether probiotics could improve via regulating microbiota unclear. Exploring specific probiotic alleviate by modulating elucidating detailed mechanisms will be essential for treating PE.PE model was induced nitric oxide (NO) inhibition L-NAME in mice, treated Limosilactobacillus reuteri (L. reuteri). 16 S rDNA analysis...