A5086644814- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- RNA Interference and Gene Delivery
- Trypanosoma species research and implications
- Wound Healing and Treatments
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Heat shock proteins research
- Molecular Biology Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Forensic Entomology and Diptera Studies
- Liver physiology and pathology
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry
- Research on Leishmaniasis Studies
- Adipose Tissue and Metabolism
- HIV/AIDS drug development and treatment
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Inflammasome and immune disorders
Henan University of Science and Technology
2015-2025
First Affiliated Hospital of Henan University of Science and Technology
2012-2023
Institute of Forensic Science
2023
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2021
Zhengzhou University
2018
Shanxi Medical University
2016-2017
Sun Yat-sen University
2005-2011
3D-printing scaffold with specifically customized and biomimetic structures gained significant recent attention in tissue engineering for the regeneration of damaged bone tissues. However, constructed scaffolds that simultaneously promote situ inhibit bacterial proliferation remains a great challenge. This study aimed to design repair antibacterial functions.Herein, general strategy is developed by using epigallocatechin-3-gallate (EGCG), major green tea polyphenol, firmly anchored...
In this study, 14 structurally novel gefitinib-1,2,3-triazole derivatives were synthesized using a click chemistry approach and characterized by 1H NMR, 13C NMR high-resolution mass spectrometry (HRMS). Preliminary cell counting kit-8 results showed that most of the compounds exhibit excellent antitumor activity against epidermal growth factor receptor wild-type lung cancer cells NCI-H1299, A549 NCI-H1437. Among them, 4b 4c prominent inhibitory effects. The half maximal concentration (IC50)...
Abstract Modification of marketed drugs is an important way to develop because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class active substances discovered in the process new drug development. Dolutegravir, HIV with nitrogen-oxygen heterocycle structure, has potential ability inhibit cell survival. In order find explore novel anti-tumor drugs, dolutegravir derivatives bearing different 1,2,3-triazole moieties were prepared via click reactions. vitro biological...
Introduction Alcoholic liver disease poses a severe threat to human health. The thyroid hormone Triiodothyronine (T3) is closely related metabolism. This study investigated the effect and mechanism of T3 in alcoholic injury. Methods Acute injury model was established mice by alcohol administration. fibrosis models were vivo vitro using hepatic stellate cells (HSC)-T6 mice. role regulatory occurrence progression acute analyzed evaluating key factors involved cell proliferation apoptosis,...
Abstract The renin-angiotensin system (RAS) and the sympathetic nervous (SNS) are two major blood pressure-regulating systems. link between renal cerebral RAS axes was provided by reflex activation of afferents efferent nerves. There is a self-sustaining enhancement brain intrarenal RAS. In this study, prenatal exposure to lipopolysaccharide (LPS) led increased activity in paraventricular nucleus (PVN) overactivation outflow, accompanied production reactive oxygen species (ROS) disturbances...
Geraniin has been reported to possess potent anti-inflammatory properties and modulate the macrophage polarization. This study sought evaluate protective effects underlying mechanisms of geraniin on lipopolysaccharide (LPS)-induced neuroinflammation neurobiological alternations as well cognitive impairment. Daily intragastrical administration with (20 mg kg–1 day–1) for 14 days significantly prolonged duration in target quadrant (26.53 ± 2.03 versus 37.09 3.27%; p < 0.05) increased...
Based on the structure of anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation cells was examined following treatment derivatives. Most compounds demonstrated significant inhibitory effects, particularly KJ-5 KJ-12 IC 50 values 4.29 ± 0.10 4.07 0.09 μM, respectively. Furthermore, both 5 12 significantly caused cell apoptosis, G2/M arrest, DNA damage,...
Heat stress will stimulate cells of living organisms to generate heat shock proteins (Hsps). In the mouse liver, impacts on hepatocyte proliferation, apoptosis and metabolism have not been studied systematically at different temperatures. this research, test mice were heated 40, 42, 44 46°C, respectively, for 20 min recovered room temperature 8 h in normal feeding conditions; control animals kept without stress. The expression levels Hsp70, Pcna, Bax, Bcl2, cytochrome P450 1A2 (CYP1A2),...
Whether proper heat shock preconditioning can reduce liver injury and accelerate repair after acute is worth study. So mice received at 40°C for 10 minutes (min), 20 min or 30 recovered room temperature 8 hours (h) under normal feeding conditions. Then was induced in the shock-pretreated unheated control by intraperitoneal (i.p.) injection of carbon tetrachloride (CCl4). Hematoxylin eosin (H&E) staining, serum aspartate aminotransferase (AST) alanine (ALT) levels expression protein 70...
Domoic acid (DA) is one of the best known marine toxins, causative important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally hippocampal area. Accumulating evidence indicates mitochondrial dysfunction oxidative stress involved DA-induced cognitive functional impairment. Therefore, therapeutics targeted to improve function increase defence could be beneficial. Quercetin, a bioflavanoid, has...
Scope The gut microbial metabolite Urolithin A (UA) exhibits anti‐inflammatory properties in vivo and vitro. Lipopolysaccharide (LPS), which is present abundance the gut, induces chronic neuroinflammation triggers behavioral abnormalities. However, neuroprotective effects of UA underlying mechanisms implicate an LPS‐elicited mouse model remain elusive. Methods results Daily administration (200 mg kg −1 d ; i.g.) for 21 days significantly mitigates cognitive deficits following LPS exposure....
Our study was undertaken to evaluate the important role of interleukin-6 (IL-6) trans-signaling in acetaminophen (AAP)-induced liver injury. A soluble gp130 protein (sgp130Fc) exclusively inhibits IL-6 trans-signaling, whereas an IL-6/soluble receptor (sIL-6R) fusion (hyper-IL-6) mimics trans-signaling. Using these tools, we investigated AAP-induced Blockade during injury remarkably increased levels serum aspartate aminotransferase and alanine aminotransferase; lowered level sIL-6R;...
Androgen deprivation therapy has become the fist-line treatment of metastatic prostate cancer; however, progression to castrate resistance disease occurs in majority patients. Thus, there is an urgent need for improvements castration-resistant cancer. The aims present study were determine efficacy somatostatin analogue octreotide (OCT) combined with a low dose docetaxel (DTX) using castration resistant cancer cells and investigate involved molecular mechanisms vitro. anti-proliferative...