A5041142805- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Metabolism and Genetic Disorders
- Structural Analysis and Optimization
- Effects of Environmental Stressors on Livestock
- HIV/AIDS drug development and treatment
- Advanced Materials and Mechanics
- Sepsis Diagnosis and Treatment
- Biochemical and Molecular Research
- Adipose Tissue and Metabolism
- HIV Research and Treatment
- Agroforestry and silvopastoral systems
- Cellular Mechanics and Interactions
- Phytochemicals and Antioxidant Activities
- Neonatal Health and Biochemistry
- Fungal Biology and Applications
- Reproductive Physiology in Livestock
- Immune Cell Function and Interaction
- Bacterial Genetics and Biotechnology
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Bioactive Compounds
- Education and Learning Interventions
- Peptidase Inhibition and Analysis
University of Copenhagen
2023-2025
Henan University of Science and Technology
2024-2025
Xi'an Jiaotong University
2022-2024
Takeda (Japan)
2024
Rigshospitalet
2024
Institute of Forensic Science
2023
Beijing Normal University - Hong Kong Baptist University United International College
2019-2022
Second Xiangya Hospital of Central South University
2022
Central South University
2022
China Agricultural University
2018-2020
In the context of peptide drug development, glycosylation plays a pivotal role. Accordingly, L-type peptides were synthesized predicated upon PD-1/PD-L1 blocker DPPA-1. Subsequent resulted in production two distinct glycopeptides, D-glu-LPPA-1 and D-gal-LPPA-1, by using D-glucose (D-glu) D-galactose (D-gal), respectively, during glycosylation. Both glycopeptides significantly inhibited interaction between PD-1 PD-L1, measured half maximal inhibitory concentrations (IC50s) 75.5 μM 101.9 for...
It has become a trend to use foldable membranes construct large spacecraft structures such as solar sails, antennas, and drag sails with the advantages of being lightweight having high packing efficiency. To enhance existing numerical simulation membrane deployment, nonlinear behavior crease is finely described based on experiments integrated into model via principle virtual work. Specifically, modeled multibody system (MBS) absolute nodal coordinate formulation (ANCF), where flexible facet...
Cervical cancer ranks as the fourth most common among women. However, current treatments have significant side effects and limited therapeutic on advanced diseases, so it is necessary to discover better for cervical cancer. The study investigated potential anticancer of a series gefitinib-1,2,3-triazole derivative Hela cells. Among investigated, target compound c13 showed good activity against cells (IC 50 = 5.66 ± 0.35 μM) compared with gefitinib 14.18 3.19 μM). Moreover, significantly...
Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage, and altered metabolism following infection. Given the unique metabolic challenges poor glucose regulatory capacity preterm infants, their intake during infection may have high impact on degree dysregulation damage. Using pig model we previously showed that drastic restriction in supply protects against sepsis via suppression glycolysis-induced inflammation, but results severe...
Energy metabolism and immune response are tightly connected, but it is poorly understood how this interplay regulated in early life to dictate host defense strategy, infection risks severity. This particularly relevant for preterm, low birthweight or otherwise immunocompromised infants, who have poor metabolic control increased of sepsis. Here, we utilized data from the COPSAC2010 cohort with 700 mother-child pairs showed that plasma levels TCA cycle metabolites were associated reduced...
Based on the structure of anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation cells was examined following treatment derivatives. Most compounds demonstrated significant inhibitory effects, particularly KJ-5 KJ-12 IC 50 values 4.29 ± 0.10 4.07 0.09 μM, respectively. Furthermore, both 5 12 significantly caused cell apoptosis, G2/M arrest, DNA damage,...
Implantation of goats with melatonin can induce cashmere growth and significantly increase production performance. However, the impact implantation on carcass characteristics, meat quality related hormone levels in muscle viscera has not been studied. This experiment was conducted to determine effects during non-growing period tissues. It aimed provide a theoretical basis for practical application goat systems.Melatonin (2 mg/kg live weight) had no influence (P > 0.05) daily weight gain,...
The standard treatment for bladder cancer (BC) is transurethral resection (TURBt), intravesical chemotherapy, and regular follow-up cystoscopy after surgery. However, some patients experience relapse or progression. Narrative care refers to a nursing model in which nurses put themselves into the patient's position through communication listening, thereby alleviating negative emotions. This study analyzed narrative interventions elderly with BC vesicoileal replacement.
Summary Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage and altered metabolism following infection. Given the unique metabolic challenges poor glucose regulatory capacity preterm infants, their intake during infection may have high impact on degree dysregulation damage. Using pig model we previously showed that drastic restriction in supply protects against sepsis via suppression glycolysis-induced inflammation, but results severe...
We introduced a terminal alkyne into the core structure of dolutegravir, resulting in synthesis 34 novel dolutegravir-1,2,3-triazole compounds through click chemistry. These exhibited remarkable inhibitory activities against two hepatocellular carcinoma cell lines, Huh7 and HepG2. Notably, 5e 5p demonstrated exceptional efficacy, particularly cells, with IC50 values 2.64 5.42 μM. Additionally, both induced apoptosis suppressed tumor clone formation, elevated reactive oxygen species (ROS)...
This study aimed to evaluate if melatonin implantation at the end of April and June was able increase cashmere production in female Inner Mongolian goats search for contributing factors accounting increasing production. One hundred fifty (initial body weight 37.2 ± 3.3 kg) were randomly assigned either a control (n=75) or treatment group. Goats group implanted with (2 mg/kg weight) on 30 30, 2014 while received no treatment. Melatonin increased yield by 23.4% length density fiber 19.8%...
Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage and altered metabolism following infection. Given the unique metabolic challenges poor glucose regulatory capacity preterm infants, their intake during infection may have high impact on degree dysregulation damage. Using pig model we previously showed that drastic restriction in supply protects against sepsis via suppression glycolysis-induced inflammation, but results severe...
Two distinct defense strategies, disease resistance (DR) and tolerance (DT), enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on DT cope with infection. However, this approach may fail when pathogen levels surpass critical threshold, prompting shift DR that can lead dysregulated immune responses sepsis. The mechanisms governing the interplay between in newborns remain poorly understood. Here, we compare metabolic traits...
Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage and altered metabolism following infection. Given the unique metabolic challenges poor glucose regulatory capacity preterm infants, their intake during infection may have high impact on degree dysregulation damage. Using pig model we previously showed that drastic restriction in supply protects against sepsis via suppression glycolysis-induced inflammation, but results severe...
Abstract Two distinct defense strategies, resistance and tolerance, enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on tolerance cope with infection. However, this approach may fail as pathogen levels surpass critical threshold, prompting shift that can lead dysregulated immune responses sepsis. The mechanisms governing the interplay between in newborns remain poorly understood. Here, we compare metabolic traits strategies...
Abstract Commercially available platforms to measure murine pulmonary gas exchange have long been used metabolic status of adult animals, thus providing insights into disease, diabetes, and infection. Metabolic is increasingly being recognized as an important modulator neonatal immunity, capturing in animals provides a non-invasive way capture physiological information health disease may reveal determinants immune-mediated diseases unique this life stage. We evaluated indirect calorimetry...
Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage, and altered metabolism following infection. Given the unique metabolic challenges poor glucose regulatory capacity preterm infants, their intake during infection may have high impact on degree dysregulation damage. Using pig model we previously showed that drastic restriction in supply protects against sepsis via suppression glycolysis-induced inflammation, but results severe...