A5022172597- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Antioxidant Activity and Oxidative Stress
- Genetic Mapping and Diversity in Plants and Animals
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Photosynthetic Processes and Mechanisms
- Immune cells in cancer
- IgG4-Related and Inflammatory Diseases
- Congenital Anomalies and Fetal Surgery
- Breast Lesions and Carcinomas
- Plant Molecular Biology Research
- Circular RNAs in diseases
- Parkinson's Disease Mechanisms and Treatments
- Parasitic Infections and Diagnostics
- Plant Water Relations and Carbon Dynamics
- Cardiac, Anesthesia and Surgical Outcomes
- Ferroptosis and cancer prognosis
Central South University
2014-2024
Third Xiangya Hospital
2014-2024
Sichuan Agricultural University
2019-2024
First Affiliated Hospital of Henan University of Science and Technology
2017-2024
China Medical University
2024
Fourth Affiliated Hospital of China Medical University
2024
Xiangya Hospital Central South University
2021-2024
GTx (United States)
2023
Anhui Agricultural University
2020-2023
Mianyang Central Hospital
2016-2023
miRNAs are involved in osteosarcoma (OS) chemoresistance, and TWIST reportedly enhances cisplatin-induced OS cell apoptosis by inhibiting multiple signaling pathways. In this study, we profiled differentially expressed chemoresistant OS, with a focus to identify that regulate expression chemoresistance. patients who showed <90% tumor necrosis after neochemotherapy were defined as poor responders (chemoresistant), those ≥90% good (control). miRNA microarray analysis was carried out discovery...
Background Sepsis is a syndrome with the disturbed host response to severe infection and major health problem worldwide. As front line of defense drug metabolism, liver vulnerable infection- or drug-induced injury. Acute injury (ALI) thus common in patients sepsis significantly associated poor prognosis. However, there are still few targeted drugs for treatment this clinics. Recent studies have reported that mesenchymal stem cells (MSCs) show potential various diseases, while molecular...
In multiple sclerosis (MS), remyelination of demyelinated lesions diminishes with disease progression for unknown reasons. Oligodendrocyte progenitor cells contribute to remyelination; however, antibodies specific oligodendrocyte antigens could block by eliminating or impeding these cells. myelinating cultures, cell lysis antibody recognizing a cell–specific surface glycoprotein (AN2) suppressed the synthesis myelin proteins. Cerebrospinal fluid from patients relapsing-remitting active MS...
As a life-threatening multiple organ dysfunction attributable to maladjusted host immune responses infection, sepsis is usually the common pathway serious prognosis and death for numerous infectious diseases all over world. Sepsis-associated encephalopathy (SAE) frequently complicated by septic conditions, one of most important reasons increased mortality poor outcomes in patients which still an urgent clinical problem need be solved. In this research, conspicuously discovery...
SUMMARY Carotenoids perform a broad range of important functions in humans; therefore, carotenoid biofortification maize ( Zea mays L.), one the most highly produced cereal crops worldwide, would have global impact on human health. PLASTID TERMINAL OXIDASE PTOX ) genes play an role metabolism; however, possible function biosynthesis has not yet been explored. In this study, we characterized locus by forward‐ and reverse‐genetic analyses. While higher plant species possess single copy gene,...
SUMMARY Maize is an important crop worldwide, as well a valuable model with vast genetic diversity. Accurate genome and annotation information for wide range of inbred lines would provide resources improvement pan‐genome characterization. In this study, we generated high‐quality de novo assembly (contig N50 15.43 Mb) the Chinese elite line RP125 using Nanopore long‐read sequencing Hi‐C scaffolding, which yield highly contiguous, chromosome‐length scaffolds. Global comparison those B73, W22,...
Various cognitive disorders have been reported for mild traumatic brain injury (mTBI) patients during the acute stage. This stage provides an opportunity clinicians to optimize treatment protocols, which are based on evaluation of structural connectivity. So far, most functional magnetic resonance imaging studies focused moderate severe injuries (TBIs). In this study, we prospectively collected resting state data 50 mTBI within 3 days and healthy volunteers analyzed them using Amplitude...
Abstract Background Flowering time is an important agronomic trait of crops and significantly affects plant adaptation seed production. varies greatly among maize ( Zea mays ) inbred lines, but the genetic basis this variation not well understood. Here, we report comprehensive architecture six flowering time-related traits using a recombinant line (RIL) population obtained from cross between two genotypes, B73 Abe2, combined with genome-wide association studies to identify candidate genes...
The identification and functional characterization of natural variants in plants are essential for understanding phenotypic adaptation. Here we identify a molecular variation At2g47310 that contributes to the flowering time Arabidopsis thaliana accessions. This gene, which term SISTER FCA (SSF), functions an antagonistic manner its close homolog FCA. Genome-wide association analysis screens two major haplotypes SSF associated with FLC expression, single polymorphism, SSF-N414D, is identified...
Acute lung injury (ALI) is a common complication of critical illness that could frequently lead to acute respiratory distress syndrome and other serious clinical consequences. Sepsis one the major most inducements among all causes ALI. Due its high incidence mortality rate also complexity in treatment, sepsis-related ALI has become an urgent problem waiting be solved effectively. At present, only protective ventilation strategy, restrictive fluid management, antibiotics application are...
This study aims to explore the effects of Notch1 gene on remyelination in multiple sclerosis (MS). A mouse model acute demyelination was successfully established and mice were grouped as cuprizone (CPZ) group, CPZ + small interfering RNA (siRNA)-Notch1 (siNotch1) siRNA negative control (NC) group. Meanwhile, another 3 groups (control, siNotch1, NC) normal mice. The changes weight maintenance time rotating drum observed. Western blot analysis for protein expressions related Notch signaling...
Demyelination causes neurological deficits involving visual, motor, sensory symptoms. Deregulation of several enzymes has been identified in demyelination, which holds potential for the development treatment strategies demyelination. However, specific effect methionine sulfoxide reductase A (MsrA) on demyelination remains unclear. Hence, this study aims to explore MsrA oxidative stress and inflammatory response microglia demyelination.Initially, we established a mouse model with induced by...
For measuring the impact in clinical and scientific research, citation count of articles is used bibliometric analysis, although there no comprehensive summary neurodegenerative disease research. This study intends to provide neuroscientists investigators with a practical reference guide appraise most important influential written on this subject through macroscopic view research activities diseases.
Scope The gut microbial metabolite Urolithin A (UA) exhibits anti‐inflammatory properties in vivo and vitro. Lipopolysaccharide (LPS), which is present abundance the gut, induces chronic neuroinflammation triggers behavioral abnormalities. However, neuroprotective effects of UA underlying mechanisms implicate an LPS‐elicited mouse model remain elusive. Methods results Daily administration (200 mg kg −1 d ; i.g.) for 21 days significantly mitigates cognitive deficits following LPS exposure....
Abstract Background Cognitive dysfunction caused by infection frequently emerges as a complication in sepsis survivor patients. However, comprehensive understanding of its pathogenesis remains elusive. Methods In our vivo experiments, an animal model endotoxemia was employed, utilizing the Novel Object Recognition Test and Morris Water Maze to assess cognitive function. Various techniques, including immunofluorescent staining, Western blotting, blood‒brain barrier permeability assessment,...
Pyroptosis, a novel form of programmed cell death, has been implicated in neurodegeneration diseases. However, its role status epilepticus (SE)—a condition characterized by prolonged or repeated seizures—remains inadequately understood. SE were induced intraperitoneal injection pilocarpine (PILO). Neuronal excitability was assessed through electroencephalogram (EEG) recordings and patch clamp. Chromatin immunoprecipitation (ChIP) assay applied to verify the interaction phosphorylated signal...
Abstract The activation of osteoblasts is significantly correlated to prostate tumor bone metastasis and loss. Oncostatin M (OSM) could promote breast cancer bone. However, its role mechanism in remain unclear. MicroRNAs (miRNAs) play important roles cancers via post‐transcriptionally regulating target genes binding specific sequences the 3′ UTR downstream genes. In present study, we performed microarray profiling analyses identify differentially‐expressed miRNAs preosteoclast before after...
The impact of serum amyloid A on cognitive impairment after ischemic stroke is unclear. We aimed to investigate the association between (SAA) levels and post-stroke (PSCI) at 3 months stroke.One hundred ninety-eight patients were enrolled prospectively from June 2020 April 2021. SAA concentrations measured using a commercially available enzyme-linked immunosorbent assay kit admission. Cognitive function was assessed Montreal Assessment score symptom onset. defined <25 as impairment.During...
In Brief BACKGROUND: The past 20 yr have seen significant growth in China's role the international community. This same and presence is occurring field of anesthesiology. research status anesthesiology among Chinese individuals 3 major regions China—mainland China, Hong Kong, Taiwan—is unknown. We analyzed articles published peer-reviewed journals cited by both PubMed Science Citation Index from these regions. METHODS: Articles 21 originating mainland Taiwan, Kong 1999 to 2008 were retrieved...