A5102710122- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Advanced Glycation End Products research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Respiratory Support and Mechanisms
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Ferroptosis and cancer prognosis
- Spine and Intervertebral Disc Pathology
- Cannabis and Cannabinoid Research
- Cancer-related molecular mechanisms research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Caveolin-1 and cellular processes
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
Harbin Medical University
2018-2024
Second Affiliated Hospital of Harbin Medical University
2018-2024
Central South University
2021-2022
Third Xiangya Hospital
2021-2022
Xiangya Hospital Central South University
2021
Acute lung injury (ALI) is a common complication of critical illness that could frequently lead to acute respiratory distress syndrome and other serious clinical consequences. Sepsis one the major most inducements among all causes ALI. Due its high incidence mortality rate also complexity in treatment, sepsis-related ALI has become an urgent problem waiting be solved effectively. At present, only protective ventilation strategy, restrictive fluid management, antibiotics application are...
Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation caspase-11 is driven by hepatocyte-released high mobility group box 1 (HMGB1), which delivers extracellular LPS into the cytosol host cells during sepsis. Using phenotypic screening strategy recombinant HMGB1 peritoneal macrophages, we discovered FeTPPS, small...
Arteriovenous fistulas (AVFs) are the most common vascular access points for hemodialysis (HD), but they have a high incidence of postoperative dysfunction, mainly due to excessive neointimal hyperplasia (NIH). Our previous studies revealed highly conserved LncRNA-LncDACH1 as an important regulator cardiomyocyte and fibroblast proliferation. Herein, we find that LncDACH1 regulates NIH in AVF male mice with conditional knockout smooth muscle cell-specific model overexpression by...
Abstract Background Membranous glomerulonephritis (MGN) is a common kidney disease. Despite many evidences support that immune and inflammation-related genes could serve as effective biomarkers treatment targets for MGN patients, the potential associations among MGN-, immune- have not been sufficiently understood. Methods Here, global immune-, inflammation- MGN-associated triplets (IIMATs) network constructed analyzed. An integrated computational approach developed to identify dysregulated...
Head and neck squamous cell carcinoma (HNSC) is a widely known malignancy which usually diagnosed late has poor prognosis. This study focuses on finding new gene linked with CD8+ T infiltration as prognostic marker for patients HNSC. Differential analysis of transcriptomic data was performed between HNSC control tissues from TCGA GEO database. The score quantified using single-sample set enrichment (ssGSEA). Weighted co-expression network (WGCNA) algorithms were used to identify key modules...
Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It evidenced that LPS, major pathological component Gram-negative bacteria membrane, predominantly contributes pathogenesis sepsis. Cytoplasmic lipopolysaccharide (LPS) can be sensed by noncanonical inflammasome and triggers oligomerization caspase-11, resulting in pyroptosis lethal immune responses A previous study has shown hepatocyte-released high mobility group box 1 (HMGB1) mediates...
Membranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adult patients. Despite extensive evidences suggested that many immune-related genes could serve as effective biomarkers MGN, potential has not been sufficiently understood because previous studies have concentrated on individual gene and entire interaction network. Here, we integrated multiple levels data containing genes, MGN-related protein–protein (PPI) networks expression profiling to construct an...
Objective To explore and analyze the influence of endoscopic lumbar discectomy on limb function quality life in patients with disc prolapse. Methods 90 cases intervertebral protrusion were selected, they divided into control group observation according to operation method, 45 each group.The was given open excision treatment, percutaneous resection treatment.The perioperative therapeutic index, physical compared between two groups. Results The intraoperative blood loss, time bed,...
Background: Sepsis, a critical global health problem, is the most common causes of death in intensive care units (ICU) although standard treatment have been shown to reduce mortality. It urging develop novel for preventing and rescuing sepsis. Previously studies show that caspase-11-GSDMD mediated pyroptosis markedly increases mortality Hundreds small chemicals were screened we find Cannabidiol (CBD) inhibit activation pathway, which may provide an effective Methods: A phenotypic screening...