A5067720126- Protein Hydrolysis and Bioactive Peptides
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Phytase and its Applications
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Insect Utilization and Effects
- Biochemical effects in animals
- Oral microbiology and periodontitis research
- Genomics and Phylogenetic Studies
- Endometrial and Cervical Cancer Treatments
- Proteins in Food Systems
- Epigenetics and DNA Methylation
- Endodontics and Root Canal Treatments
- Phytochemical Studies and Bioactivities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Extracellular vesicles in disease
- Biomarkers in Disease Mechanisms
- Reproductive System and Pregnancy
- Plant Disease Resistance and Genetics
- Adolescent and Pediatric Healthcare
- Chromosomal and Genetic Variations
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
Richmond University Medical Center
2025
Nanjing Medical University
2020-2024
Chongqing Three Gorges Academy of Agricultural Sciences
2024
Nanjing Jiangning Hospital
2021-2023
Sichuan Agricultural University
2021
Haier Group (China)
2018
Dalhousie University
2013-2017
Changshu Institute of Technology
2015
Kunming Medical University
2012
Abstract Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, most them with high-grade transit to cervical squamous cell carcinoma (CSCC). The oxysterol 25-hydroxycholesterol (25-HC) is associated HPV inhibition, autophagy cholesterol synthesis, however, its function this long process SIL development remain unclear. In study, we demonstrate that 25-HC generation inhibited through HSIL-to-CSCC...
To investigate the effects of an online health education lecture on positive screening rate attention-deficit/hyperactivity disorder (ADHD) and parenting stress among parents children diagnosed with or screened for ADHD. Using stratified proportional random cluster sampling, 14 primary schools in Chongqing were selected to conduct about ADHD teachers. A total 2,611 questionnaires collected (1,508 intervention group, 1,103 control group). The did not significantly affect (parents: β=-0.37,...
Abstract Cervical squamous cell carcinoma (CSCC) is a type of female cancer that affects millions families worldwide. Human papillomavirus (HPV) infection the main reason for CSCC formation, and intraepithelial lesions (SILs) induced by high-risk HPV (HR-HPV) are considered precancerous lesions. A previous study reported HPV-infected cells were able to counteract lipid peroxidation survival. Recent research has ferroptosis acts in an iron-dependent manner kill cells, it proposed as new...
SUMMARY Maize is an important crop worldwide, as well a valuable model with vast genetic diversity. Accurate genome and annotation information for wide range of inbred lines would provide resources improvement pan‐genome characterization. In this study, we generated high‐quality de novo assembly (contig N50 15.43 Mb) the Chinese elite line RP125 using Nanopore long‐read sequencing Hi‐C scaffolding, which yield highly contiguous, chromosome‐length scaffolds. Global comparison those B73, W22,...
Hydrolysis of spent hen meat proteins with pepsin and + pancreatin yielded SPH-P SPH-PPc hydrolysates, respectively. The hydrolysates dose-dependently inhibited activities human recombinant renin (IC50 0.34 0.52 mg/mL, respectively) angiotensin I-converting enzyme (ACE, IC50 0.64 0.42 respectively). had lower cysteine tryptophan contents but similar other amino acids when compared the parent protein isolate. SPH-P, not SPH-PPc, increased sulfhydryl content ferric reducing antioxidant...
<b><i>Introduction:</i></b> Focal segmental glomerulosclerosis (FSGS) is a common glomerulopathy with an unclear mechanism. The demand for FSGS clinical diagnostic biomarkers has not yet been met. Circular RNA (circRNA) novel non-coding multiple functions, but its value remains unexplored. This study aimed to identify circRNAs that could aid in early diagnosis and investigate their mechanisms podocyte injury. <b><i>Methods:</i></b> signature of...
Plastein, a product of protease-induced peptide aggregation, is thought to possess unique physical properties and bioactivity, although its formation, stability, functional mechanisms remain unclear. This study demonstrates that plastein formed from bovine casein peptides with Alcalase by hydrophobic electrostatic interactions less likely covalent bonding. The aggregation enhanced the Fe(III) reducing potential decreased Fe(II) chelating activity (p < 0.05) peptides, but there was no...
Necroptosis is a novel type of programmed cell death distinct from apoptosis. However, the role necroptosis in ovarian cancer (OC) remains unclear. The present study investigated prognostic value necroptosis-related genes (NRGs) and immune landscape OC. gene expression profiling clinical information were downloaded TCGA GTEx databases. Differentially expressed NRGs (DE-NRGs) between OC normal tissueswere identified. regression analyses conducted to screen construct predictive risk model....
Polycystic ovary syndrome (PCOS) is a condition resulting from the interaction between environmental factors and hereditary components, profoundly affecting offspring development. Although etiology of this disease remains unclear, aberrant in utero androgen exposure considered one pivotal pathogenic factors. Herein, we demonstrate intergenerational inheritance PCOS-like phenotypes F2 female through F1 males caused by maternal testosterone F0 mice. We found impaired serum hormone expression...
Long non-coding RNAs (lncRNAs) play important roles in many diseases and participate posttranscriptional regulatory networks tumors. However, the functions of major lncRNAs cervical cancer are unclear. Therefore, aim this study was to construct a lncRNA-mRNA coexpression functional network analyze that might contribute pathogenesis cancer.Differentially expressed (DElncRNAs) mRNAs (DEmRNAs) between three pairs tissues adjacent mucosa were identified by lncRNA microarray analysis. LncRNA-mRNA...
Hyperandrogenism is considered 1 of the most important characteristics polycystic ovary syndrome, which affects more than 10% females reproductive age and a common cause infertility. In addition to effects on patients themselves, maternal androgen excess has also been reported impair growth development offspring. our current study, we found that testosterone (T) treatment during different gestational stages increased percentage atretic follicle decreased corpus luteum formation in female...
Diabetic nephropathy (DN) is one of the most serious and dangerous chronic complications caused by diabetes mellitus, identification development novel biomarkers could be beneficial for diagnosis prognosis DN patients. This study focused on researching differently expressed pattern samples from glomeruli tubulointerstitium. Significance analysis microarrays (SAM) was used to identify differentially regulated genes in 44 microdissected human kidney samples. Functional enrichment analyze...
Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially pancreatic beta-cell function, is rarely investigated. Our current study mainly focused effects prenatal metabolism and beta- cell function aged By using mice their offspring as animal models, we found that treatment induced obesity intolerance These influences were accompanied by decreased fasting serum insulin...
Endometrial stromal sarcoma (ESS) is a rare disease in patients with uterine malignancies, accounting for <1%. Low-grade endometrial (LGESS) accounts merely 0.2% of gynecologic malignant tumor. Primary low-grade extrauterine endometrioid sarcomas (LGEESS) even more uncommon, only few documented case reports. We report primary LGEESS exhibiting widely invasion multiple organs after hysterectomy, which the first reported Jiangsu Province China.A 42-year-old nulliparous female dysgnosia...